Molecular biology of picornaviruses / edited by Bert L. Semler, Eckard Wimmer.

Format:

Book

Contributor:

Semler, Bert L.

Wimmer, Eckard.

Language:

English

Subjects (All):

Picornaviruses.

Picornavirus infections.

Molecular Biology.

Picornaviridae.

Picornaviridae--genetics.

Picornaviridae Infections.

Poliomyelitis--prevention & control.

Poliovirus.

Medical Subjects:

Molecular Biology.

Picornaviridae.

Picornaviridae--genetics.

Picornaviridae Infections.

Poliomyelitis--prevention & control.

Poliovirus.

Physical Description:

xix, 502 pages, xxiv pages of plates : illustrations (some color) ; 29 cm

Place of Publication:

Washington, D.C. : ASM Press, [2002]

Summary:

The field of picornavirus research has exploded over the past decade, placing picornavirus research at the forefront of discovery in molecular virology and yielding a wealth of information on nearly all aspects of picornavirus biology and disease. However, until now this information has not been available in a single, readily accessible volume. Molecular Biology of the Picornaviruses offers an up-to-date, in-depth analysis of all major aspects of picornavirus research, providing a summary of the many significant accomplishments in picornavirus research as well as a road map of the path to future discoveries.

-- Single source of key information on picornavirus research

-- Up-to-date and in-depth analysis

-- Contributions from leading researchers in the field

Contents:

Historical Perspective

1. History of Poliomyelitis and Poliomyelitis Research / Hans J. Eggers 3

Taxonomy

2. Molecular and Biological Basis of Picornavirus Taxonomy / Glyn Stanway, Tapani Hovi, Nick J. Knowles, Timo Hyypia 17

Virion Structure

3. Picornavirus Structure Overview / Michael G. Rossmann 27

4. Antibody Interactions with Rhinovirus / Thomas J. Smith 39

5. Antigenic Variation in Foot-and-Mouth Disease Virus / David J. Rowlands, Fred Brown 51

Virus Entry

6. Cellular Receptors of Picornaviruses: an Overview / Elizabeth Rieder, Eckard Wimmer 61

7. Poliovirus Receptors and Cell Entry / James M. Hogle, Vincent R. Racaniello 71

8. Interaction of Major Group Rhinoviruses with Their Cellular Receptor, ICAM-1 / Richard J. Kuhn, Michael G. Rossmann 85

9. Human Rhinovirus Minor Group Receptors / Dieter Blaas 93

10. Receptors for Coxsackieviruses and Echoviruses / Jeffery M. Bergelson 107

11. Foot-and-Mouth Disease Virus-Receptor Interactions: Role in Pathogenesis and Tissue Culture Adaptation / Barry Baxt, Sherry Neff, Elizabeth Rieder, Peter W. Mason 115

Viral Genomes

12. Picornavirus Genome: an Overview / Vadim A. Agol 127

13. Alignments and Comparative Profiles of Picornavirus Genera / Ann C. Palmenberg, Jean-Yves Sgro 149

Initiation of Translation

14. Initiation of Translation of Picornavirus RNAs: Structure and Function of the Internal Ribosome Entry Site / Ellie Ehrenfeld, Natalya L. Teterina 159

15. Proteins Involved in the Function of Picornavirus Internal Ribosomal Entry Sites / Richard J. Jackson 171

Proteolytic Processing

16. Processing Determinants and Functions of Cleavage Products of Picornavirus Polyproteins / Louis E.-C. Leong, Christopher T. Cornell, Bert L. Semler 187

17. Structure and Function of Picornavirus Proteinases / Tim Skern, Bernhard Hampolz, Alba Guarne, Ignacio Fita, Ernst Bergmann, Jens Petersen, Michael N. G. James 199

18. The Aphtho- and Cardiovirus "Primary" 2A/2B Polyprotein "Cleavage" / Martin D. Ryan, Garry Luke, Lorraine E. Hughes, Vanessa M. Cowton, Edwin Ten Dam, Xuejun Li, Michelle L. L. Donnelly, Amit Mehrotra, David Gani 213

Viral RNA Replication

19. Possible Unifying Mechanism of Picornavirus Genome Replication / Aniko V. Paul 227

20. Role of Cellular Structures in Viral RNA Replication / Denise Egger, Rainer Gosert, Kurt Bienz 247

21. Poliovirus RNA-Dependent RNA Polymerase (3D[superscript pol]): Structure, Function, and Mechanism / Craig E. Cameron, David W. Gohara, Jamie J. Arnold 255

22. Picornavirus Genetics: an Overview / Vadim A. Agol 269

23. Error Frequencies of Picornavirus RNA Polymerases: Evolutionary Implications for Virus Populations / Esteban Domingo, Eric Baranowski, Cristina Escarmis, Francisco Sobrino, John J. Holland 285

Shutoff of Host Cell Translation and Transcription

24. Picornavirus Proteinase-Mediated Shutoff of Host Cell Translation: Direct Cleavage of a Cellular Initiation Factor / Ernst Kuechler, Joachim Seipelt, Hans-Dieter Liebig, Wolfgang Sommergruber 301

25. Poliovirus-Mediated Shutoff of Host Translation: an Indirect Effect / Miguel Zamora, Wilfred E. Marissen, Richard E. Lloyd 313

26. Effects of Picornavirus Proteinases on Host Cell Transcription / Asim Dasgupta, Padmaja Yalamanchili, Melody Clark, Steven Kliewer, Lee Fradkin, Sheryl Rubinstein, Saumitra Das, Yuhong Shen, Mary K. Weidman, Rajeev Banerjee, Utpal Datta, Megan Igo, Pallob Kundu, Bhaswati Barat, Arnold J. Berk 321

27. Effects of Viral Replication on Cellular Membrane Metabolism and Function / Luis Carrasco, Rosario Guinea, Alicia Irurzun, Angel Barco 337

Pathogenicity

28. Clinical Significance, Diagnosis, and Treatment of Picornavirus Infections / Harley A. Rotbart 357

29. Determinants of Poliovirus Pathogenesis / Matthias Gromeier, Akio Nomoto 367

30. Poliovirus Vaccines: Molecular Biology and Immune Response / P. D. Minor, J. Almond 381

31. Immunology of the Coxsackieviruses / Nora M. Chapman, Charles J. Gauntt, Steve Tracy 391

32. Pathogenesis of Coxsackievirus B Infections / Reinhard Kandolf, Hans-Christoph Selinka, Karin Klingel 405

33. Hepatitis A Virus Pathogenesis and Attenuation / Robert H. Purcell, Suzanne U. Emerson 415

34. Pathogenesis of Theiler's Murine Encephalomyelitis Virus-Induced Disease / Raymond P. Roos 427

35. Persistent Infections by Picornaviruses / Florence Colbere-Garapin, Isabelle Pelletier, Laurent Ouzilou 437

Cell-Free Synthesis and Cell-Free Genetics of Poliovirus

36. Cell-Free Genetics of Poliovirus / Rohit Duggal 451

37. Poliovirus RNA Replication and Genetic Complementation in Cell-Free Reactions / David J. Barton, B. Joan Morasco, Lucia Eisner Smerage, James B. Flanegan 461

Global Eradication of Poliovirus

38. Global Eradication of Poliovirus: History and Rationale / Walter R. Dowdle, Stephen L. Cochi 473

39. The Mechanism of Poliovirus Eradication / Olen M. Kew, Mark A. Pallansch 481.

Notes:

Includes bibliographical references and index.

ISBN:

1555812104

OCLC:

50002637