The hereditary basis of allergic diseases / Stephen T. Holgate, John W. Holloway, editors.

Format:

Book

Contributor:

Holgate, S. T.

Holloway, John W., 1971-

Series:

PIR (Series)

Progress in inflammation research

Language:

English

Subjects (All):

Allergy--Genetic aspects.

Allergy.

Hypersensitivity--genetics.

Medical Subjects:

Hypersensitivity--genetics.

Physical Description:

xii, 179 pages : illustrations ; 24 cm.

Place of Publication:

Basel ; Boston : Birkhäuser, [2002]

Summary:

Allergic diseases are complex and involve a range of environmental factors interacting with a susceptible genotype. The familial clustering of diseases, such as asthma and hay fever, has been recognised for over two centuries, but identification of the genetic basis to this had to await the molecular biological revolution. Estimates of the contribution that genetic factors make to asthma susceptibility range from 35% to 70%. For the majority of allergic diseases, segregation analysis has not identified a consistent Mendelian pattern of inheritance, which, when combined with multiple phenotypes and environmental interactions, has made identifying candidate genes especially difficult and, at times, controversial. Part of the difficulty has been lack of agreement over phenotype definitions, reduced power of studies to predict linkage and association, and importantly, lack of true heterogeneity between populations.

Despite these difficulties, the last decade has witnessed enormous progress in this field. The Hereditary Basis of Allergic Diseases brings together scholarly reviews of the emergent and promising genetic factors influencing susceptibility to and progression of allergic diseases such as asthma. This book is aimed at those clinicians and scientists with an interest in allergic diseases. It aims through reviews of a number of different studies in the field to not only provide a review of current knowledge but also examples of the processes by which the genetic factors that contribute to allergic disease are being elucidated by workers in the field.

Contents:

Heredity of allergy and asthma / Tarja Laitinen 1

Genome scans for asthma / Matthias Wjst 17

The role of founder populations in mapping complex disease genes: Studies in the South Dakota Hutterites / Carole Ober 29

Genetic regulation of specific IgE responsiveness / Nobuyuki Hizawa 37

Genetic variation at the HLA and TCR loci and the development of allergy and asthma / Adel H. Mansur 55

Chromosome 11q13, Fc[varepsilon]RI[beta] and atopic asthma / Chaker N. Adra, X.-Q. Mao, A. Yamasaki, P.-S. Gao, Xing Yang, T. Shirakawa, J.M. Hopkin 85

Genetic regulation of interleukin-13 production / Tineke C.T.M. van der Pouw Kraan, John W. Holloway, Lucien A. Aarden, Jaring S. van der Zee 95

The role of interleukin-9 and the interleukin-9 receptor gene candidates in asthma / Roy C. Levitt, Michael P. McLane, Luigi Grasso, Nicholas C. Nicolaides 113

Genetics of the nitric oxide synthetic pathway in asthma / Hartmut Grasemann, Jeffrey M. Drazen 125

Genetic regulation of leukotriene production and activity / I. Sayers, A.P. Sampson 137

Genetics of asthma severity / Ladina Joos, Peter D. Pare, Andrew J. Sandford 167.

Notes:

Includes bibliographical references and index.

ISBN:

3764364025

OCLC:

49250173