Calcium-activated chloride channels / edited by Catherine Mary Fuller.

Format:

Book

Contributor:

Fuller, Catherine Mary.

Series:

Current topics in membranes ; v. 53.

Current topics in membranes ; v. 53

Language:

English

Subjects (All):

Chloride Channels--physiology.

Calcium--physiology.

Medical Subjects:

Chloride Channels--physiology.

Calcium--physiology.

Physical Description:

xxv, 441 pages, 1 leaf of plates : illustrations (some color) ; 24 cm.

Place of Publication:

Amsterdam ; Boston : Academic Press, 2002.

Summary:

This volume draws together studies on the diverse group of calcium-activated chloride channels (CaCCS) in one comprehensive format. The characteristics of CaCCs identified in a number of different systems are described by experts in the field. Channels discussed include those described in cardiac, neuronal, endothelial and epithelial systems, in addition to sections on the CaCC of "Xenopus" Oocytes and the newly identified family of CLCA proteins. Key Features* Includes description of CaCCs in excitable and non-excitable tissues* Reviews identification and cloning of the CLCA protein family* Contains section on CaCCs in "Xenopus" Oocytes

Contents:

Part I CaCCs in Xenopus Oocytes

Chapter 1 The Endogenous Calcium-Activated Cl Channel in Xenopus Oocytes: A Physiologically and Biophysically Rich Model System / Khaled Machaca, Zhiqiang Qu, Akinori Kuruma, H. Criss Hartzell, Nael McCarty

II. Physiological Roles of Ca[superscript 2+]-Activated Cl[superscript -] Channels in Xenopus Eggs 4

III. Mechanisms of Gating of Cl(Ca) Channels in Oocytes 11

IV. Anion Permeation in Cl(Ca) Channels 18

V. Toward a Definition of Cl Selectivity 23

Chapter 2 Ca[superscript 2+]-Inactivated Cl[superscript -] Channels in Xenopus laevis Oocytes / Wolf-Michael Weber

II. Basal Properties 42

III. Pharmacological Profile 47

IV. Regulation of CaIC 49

V. Developmental Events 50

VI. Comparison with Ca[superscript 2+]-Inactivated Cl[superscript -] Channels from Other Cells 51

Part II Ca[superscript 2+]-Activated Cl[superscript -] Currents in Excitable Tissues

Chapter 3 A Ca[superscript 2+]-Activated Anion Channel in the Sarcoplasmic Reticulum of Skeletal Muscle / Angela F. Dulhunty, Derek R. Laver

II. Types of Anion Channels in the Sarcoplasmic Reticulum 63

III. Properties of the Ca[superscript 2+]-Activated SCl Channel in Skeletal Muscle 67

IV. The Function of the SCl Channel 72

Chapter 4 Physiological Role of the Ca[superscript 2+]-Activated Cl[superscript -] Current in Mammalian Heart / Andrew C. Zygmunt

I. Identification of the Calcium-Activated Current in Mammalian Heart 81

II. Characterization of I[subscript Cl(Ca)] 82

III. Physiological Role of I[subscript Cl(Ca)] 89

Chapter 5 Recent Advances on the Properties and Role of Ca[superscript 2+]-Activated Chloride Currents in Smooth Muscle / W. A. Large, I. A. Greenwood, A. S. Piper

II. Intracellular Cl[superscript -] Activity and Membrane Cl[superscript -] Permeability in Smooth Muscle 100

III. General Properties of I[subscript Cl(Ca)] in Smooth Muscle 100

IV. Kinetics of Ca[superscript 2+]-Activated Cl[superscript -] Currents 104

V. Unitary Ca[superscript 2+]-Activated Cl[superscript -] Channels 109

VI. Physiological Role of I[subscript Cl(Ca)] in Smooth Muscle 111

Chapter 6 The Calcium-Activated Chloride Conductance in Olfactory Receptor Neurons / Steven J. Kleene

II. Transduction in Olfactory Receptor Neurons 120

III. Channel Properties 121

IV. Electrochemical Gradients at the Ciliary Membrane 126

V. Physiological Function of the Channel 129

Chapter 7 Ca[superscript 2+]-Activated Cl[superscript -] Channels as Ca[superscript 2+] Sensors with Particular Reference to the Modulation of Neuronal Excitability / James L. Kenyon, Roderick H. Scott

I. Function and Significance of Ca[superscript 2+]-Activated Cl[superscript -] Channels 135

II. Activation of Ca[superscript 2+]-Activated Cl[superscript -] Channels by [Ca superscript 2+ subscript i] and Voltage 137

III. Activation of Neuronal Ca[superscript 2+]-Activated Cl[superscript -] Channels by Ca[superscript 2+] Influx 141

IV. Activation of Ca[superscript 2+]-Activated Cl[superscript -] Channels by Mobilization of Ca[superscript 2+] from Intracellular Stores 152

V. Activation of Ca[superscript 2+]-Activated Cl[superscript -] Channels by Ligand-Gated Channels 155

VI. Issues of Topography 155

VII. What We Know and What We Don't Know about Ca[superscript 2+]-Activated Cl[superscript -] Channels and the Prospects for Learning More 157

Chapter 8 Determination of Intracellular Chloride Concentration in Dorsal Root Ganglion Neurons by Fluorescence Lifetime Imaging / Hiroshi Kaneko, Ilva Putzier, Stephan Frings, Thomas Gensch

II. Fluorescence Lifetime Microscopy with Two-Photon Excitation (TP-FLIM) 169

III. Fluorescence Lifetime Analysis of Cl[superscript -] Concentration 177

IV. Determination of Intracellular Cl[superscript -] Concentration in Rat DRG Neurons 181

Part III CA[superscript 2+]-Activated CL[superscript -] Currents in Non-Excitable Tissues

Chapter 9 Calcium-Activated Cl[superscript -] Conductance in the Airway Epithelium / Sherif E. Gabriel

II. Respiratory Anatomy and Airway Surface Liquid 194

III. Model for Ion Transport in the Airway 195

IV. Regulation of Cl[superscript -] Secretion 196

V. Characteristics of CaCC 197

VI. CaCC in CF Airways 201

VII. The Genes that Encode CaCC 203

Chapter 10 Ca[superscript 2+]-Activated Cl[superscript -] Currents in Salivary and Lacrimal Glands / James E. Melvin, Jorge Arreola, Keith Nehrke, Ted Begenisich

I. The Function of Ca[superscript 2+]-Dependent Cl[superscript -] Channels in the Fluid Secretion Mechanism 209

II. Properties of Ca[superscript 2+]-Activated Cl[superscript -] Channels in Acinar Cells 214

III. Molecular Identity of the Ca[superscript 2+]-Activated Cl[superscript -] Channels in Acinar Cells 220

Chapter 11 Properties and Role of Calcium-Activated Chloride Channels in Pancreatic Duct Cells / Michael A. Gray, John P. Winpenny, Bernard Verdon, Catherine M. O'Reilly, Barry E. Argent

I. Structure and Function of the Exocrine Pancreas 231

II. Regulation of Exocrine Function 233

III. Role of Anion Channels in Pancreatic Ductal HCO[superscript - subscript 3] Transport 235

IV. Regulation of CaCCs 244

V. Ca[superscript 2+]-Activated Cl[superscript -] Channels and Cystic Fibrosis 248

VI. Future Research 251

Chapter 12 Calcium-Mediated Chloride Secretion in the Intestinal Epithelium: Significance and Regulation / Kim E. Barrett

II. Mechanisms of Calcium-Mediated Chloride Secretion 261

III. Intracellular Regulation of Calcium-Mediated Secretion 268

Chapter 13 Renal Expression of Ca[superscript 2+]-Activated Cl[superscript -] Channels / S. Boese, J. Sayer, G. Stewart, M. Glanville, M. A. Gray, N. L. Simmons

I. Role of Cl[superscript -] Channels in Renal Function and in Health and Disease 283

II. The Inner Medullary Collecting Duct (IMCD) is Capable of Transepithelial Cl[superscript -] Secretion 286

III. Biophysical Characterization of Ca[superscript 2+]-Activated Cl[superscript -] Channels 287

IV. Evidence for CaCC in Renal Epithelial Cells 288

V. Molecular Basis of Renal CaCC 299

VI. Expression of CLCA along the Nephron 302

VII. Interactions between Cl[superscript -] Channels 302

VIII. Future Perspectives 303

Chapter 14 Calcium-Dependent Anion Secretion in Endometrial Epithelial Cells / Melissa Palmer-Densmore, Scott M. O'Grady

II. Anion Secretion in Mammalian Endometrial Epithelial Cells 310

Chapter 15 Calcium-Activated Chloride Channels in Vascular Endothelial Cells / Bernd Nilius, Guy Droogmans

II. Biophysical Properties of ClCa in Endothelium 328

III. Mechanism of Activation 331

IV. Pharmacology 335

V. Activation by Calmodulin-Dependent Protein Kinase 336

VI. Molecular Nature of ClCa in Endothelium 337

Chapter 16 Regulation of Calcium-Activated Chloride Channels by Inositol 3,4,5,6-Tetrakisphosphate / Melisa W. Y. Ho, Stephen B. Shears

II. Synthesis and Regulation of Ins(3,4,5,6)P[subscript 4] Levels 346

III. Ins(3,4,5,6)P[subscript 4] Inhibits Epithelial Cl[superscript -] Secretion 350

IV. Ins(3,4,5,6)P[subscript 4] and the Regulation of CaCC by Ca[superscript 2+] and CaMKII 353

V. Specificity and Cooperativity of Ins(3,4,5,6)P[subscript 4] Action 357

Part IV The CLCA Family

Chapter 17 Discovery and Cloning of the CLCA Gene Family / Achim D. Gruber, Randolph C. Elble, Bendicht U. Pauli

II. Identification of a Novel Gene Family 368

III. Bovine CLCA Homologs 369

IV. Murine CLCA Homologs 373

V. Human CLCA Homologs 374

VI. A First Procine CLCA Homolog 377

VII. Structure of CLCA Proteins 378

VIII. Evolution of the CLCA Family 381

IX. CLCA Homologs and Disease 383

X. Future Prospects 385

Chapter 18 Electrophysiology of the CLCA Family / Catherine M. Fuller, Dale J.

Benos

II. Ca[superscript 2+]-Mediated Cl[superscript -] Secretion in Epithelial Cells 390

III. Regulation of Endogenous Ca[superscript 2+]-Mediated Cl[superscript -] Conductances 393

IV. Role of the CaCC in CF Mouse Models 394

V. Cloned Epithelial Anion Channels 395

VI. The CLCA Family 399

Chapter 19 CLCA Adhesion in Site-Specific Cancer Metastasis / Bendicht U. Pauli, Hung-Chi Cheng, Mossaad Abdel-Ghany

I. Historical Background 415

II. The Mouse Homolog of Lu-ECAM-1 and Its Role in Lung Metastasis 417

III. The Human Functional Counterpart of Lu-ECAM-1: hCLCA2 418

IV. The [beta subscript 4] Integrin Is the Adhesion Partner for hCLCA2 419

V. Functional Implications of the [beta subscript 4]/hCLCA2 Adhesion in Metastasis 421.

Notes:

Includes bibliographical references and index.

ISBN:

0121533530

OCLC:

50731563