Cancer metastasis : related genes / edited by Danny R. Welch.

Format:

Book

Contributor:

Welch, D. R. (Danny R.)

Series:

Cancer metastasis (Series) ; v. 3.

Cancer metastasis ; v. 3

Language:

English

Subjects (All):

Metastasis--Genetic aspects.

Metastasis.

Neoplasm Metastasis--genetics.

Medical Subjects:

Neoplasm Metastasis--genetics.

Physical Description:

xiii, 270 pages : illustrations ; 25 cm.

Place of Publication:

Dordrecht ; Boston : Kluwer Academic Publishers, 2002.

Summary:

This volume is the first attempt to summarize current knowledge about the underlying molecular and biochemical mechanisms controlling the metastatic phenotype. While all of the other authors attempted to put their findings into a context for translation to the clinical situation, the state-of-the-art does not fully allow this because the field of metastasis genetics is relatively new. Nonetheless, the contents of this volume will be of use to members of the cancer research community and clinicians interested in developing and implementing novel forms for the treatment of cancer.

Contents:

Chapter 1 Metastasis-Suppressor Genes: A Review and Perspective on an Emerging Field / Barbara A. Yoshida, Zita Dubauskas, Mitchell H. Sokoloff, Danny R. Welch, Carrie W. Rinker-Schaeffer 1

Chapter 2 The Roles of Map Kinases in Controlling Cancer Metastasis / Alessandro Alessandrini 35

Chapter 3 Tumor Metastasis-associated Human Mtal Gene: Role in Epithelial Cancer Cell Proliferation and Regulation / Garth L. Nicolson, Akihiro Nawa, Yasushi Toh, Shigeki Taniguchi, Katsuhiko Nishimori 51

Chapter 4 Cooperative Integrin Interactions in the Regulation of Tumor Metastasis / Peter C. Brooks 65

Chapter 5 Brain Metastasis Associated Genes / Dario Marchetti 89

Chapter 6 Autocrine Motility Factor and its Receptor as Regulators of Metastasis / Yasuharu Onishi, Arayo Haga, Avraham Raz 109

Chapter 7 nm23 Metastasis Suppressor Gene / Patricia S. Steeg, Taoufik Ouatas, Michael Mair, Susan E. Clare, Melanie T. Hartsough 123

Chapter 8 Gene Regulation in Melanoma Metastasis / Menashe Bar-Eli 145

Chapter 9 Heterochromatin-associated Protein 1, HP1[superscript Hs[alpha], in Breast Cancer Invasion and Metastasis / Dawn A. Kirschmann, Mary J.C. Hendrix 169

Chapter 10 Inhibition of Invasion and Metastasis During Specific Amino Acid Restriction Associated with Metastasis Suppressor and Other Gene Changes / Gary G. Meadows, Xiaokang Ge, Hui Zhang, Daniel R. Oros, Ya-Min Fu 191

Chapter 11 Role of BRMS1 in Breast Carcinoma Metastasis / Rajeev S. Samant, Lalita R. Shevde, Danny R. Welch 209

Chapter 12 The Role of KISS1 in Melanoma Metastasis Suppression / John F. Harms, Danny R. Welch 219

Chapter 13 Osteopontin: a Ras-regulated Gene That Contributes to Tumor Metastasis / Ann F. Chambers, Alan B. Tuck 231

Chapter 14 The Emerging Role for the mRNA Cap-binding Protein, EIF-4E, in Metastatic Progression / Stephen G. Zimmer, Jeremy R. Graff 247.

Notes:

Includes bibliographical references and index.

ISBN:

1402005229

OCLC:

49903062