Molecular biology of drug addiction / edited by Rafael Maldonado.

Format:

Book

Contributor:

Maldonado, Rafael, 1961-

Language:

English

Subjects (All):

Drug abuse--Molecular aspects.

Drug abuse.

Substance-Related Disorders--pathology.

Medical Subjects:

Substance-Related Disorders--pathology.

Physical Description:

x, 346 pages : illustrations ; 26 cm

Place of Publication:

Totowa, N.J. : Humana Press, [2003]

Summary:

A comprehensive multidisciplinary review of the most relevant molecular, genetic, and behavioral approaches used to investigate the neurobiological basis of drug addiction. The authors explore the latest findings on opioid, psychostimulant, cannabinoid, alcohol, and nicotine addiction, provide fresh insights into the genetic basis of drug addiction and the new therapeutic perspectives these have opened. They describe the technology available to generate conditional knockout mice and show how these mice can reveal the molecular basis of opioid, psychostimulant, and cannabinoid addiction. They also review the different behavioral models available to evaluate the rewarding effects of drugs and analyze the genes involved in alcohol dependence.

Contents:

Part I. Opioid Addiction

1 Molecular Mechanisms of Opioid Dependence by Using Knockout Mice / Brigitte L. Kieffer, Frederic Simonin 3

2 Molecular Genetic Approaches / Theo Mantamadiotis, Gunther Schutz, Rafael Maldonado 27

3 Opiate Addiction: Role of the cAMP Pathway and CREB / Lisa M. Monteggia, Eric J. Nestler 37

4 Different Intracellular Signaling Systems Involved in Opioid Tolerance/Dependence / Thomas Koch, Stefan Schulz, Volker Hollt 45

5 Inhibitors of Enkephalin Catabolism: New Therapeutic Tool in Opioid Dependence / Florence Noble, Bernard P. Roques 61

Part II. Psychostimulant Addiction

6 Recent Advances in the Molecular Mechanisms of Psychostimulant Abuse Using Knockout Mice / Cecile Spielewoy, Bruno Giros 79

7 Opioid Modulation of Psychomotor Stimulant Effects / Toni S. Shippenberg, Vladimir I. Chefer 107

8 Influence of Environmental and Hormonal Factors in Sensitivity to Psychostimulants / Michela Marinelli, Pier Vincenzo Piazza 133

9 Development and Expression of Behavioral Sensitization: Temporal Profile of Changes in Gene Expression / Peter W. Kalivas 161

Part III. Cannabinoid Addiction

10 New Advances in the Identification and Physiological Roles of the Components of the Endogenous Cannabinoid System / Ester Fride, Raphael Mechoulam 173

11 Integration of Molecular and Behavioral Approaches to Evaluate Cannabinoid Dependence / Dana E. Selley, Aron H. Lichtman, Billy R. Martin 199

12 Opioid System Involvement in Cannabinoid Tolerance and Dependence / Rafael Maldonado 221

Part IV. Alcohol and Nicotine Addiction

13 Current Strategies for Identifying Genes for Alcohol Sensitivity / John C. Crabbe 249

14 Genetic Basis of Ethanol Reward / Christopher L. Cunningham, Tamara J. Phillips 263

15 Behavioral and Molecular Aspects of Alcohol Craving and Relapse / Rainer Spanagel 295

16 Molecular and Behavioral Aspects of Nicotine Dependence and Reward / Emilio Merlo Pich, Christian Heidbreder, Manolo Mugnaini, Vincenzo Teneggi 315.

Notes:

Includes bibliographical references and index.

ISBN:

1588290603

OCLC:

49495118