Psychiatric genetics : methods and reviews / edited by Marion Leboyer and Frank Bellivier.

Format:

Book

Contributor:

Leboyer, Marion.

Bellivier, Frank.

Series:

Methods in molecular medicine ; 77.

Methods in molecular medicine ; 77

Language:

English

Subjects (All):

Mental illness--Genetic aspects.

Mental illness.

Behavior genetics.

Psychophysiology--Genetic aspects.

Psychophysiology.

Mental Disorders--genetics.

Epidemiologic Research Design.

Genetic Techniques.

Mental Disorders--epidemiology.

Medical Subjects:

Mental Disorders--genetics.

Epidemiologic Research Design.

Genetic Techniques.

Mental Disorders--epidemiology.

Physical Description:

ix, 268 pages : illustrations ; 22 cm.

Place of Publication:

Totowa, N.J. : Humana Press, [2003]

Summary:

Psychiatric Genetics provides the reader with a complete view of the methodological problems encountered in psychiatry genetics and proposes solutions to commonly occurring questions. The best European and American specialists have given a thorough review on the advantages and disadvantages of genetic epidemiological methods, the way to choose a genetic marker or a clinical interview and how to ascertain patients, unaffected relatives and controls and what should be the criteria to include a case or a control. New phenotypic methods are described focusing on candidate symptom and endophenotype approaches. Examples coming from cognitive neurosciences, biochemistry, electrophysiology and brain imaging techniques are reviewed. This book will serve as an essential handbook for psychiatrists, psychologists, and geneticists involved in the genetics of psychiatric disorders.

Contents:

1 Psychiatric Genetics: Overview on Achievements, Problems, Perspectives / Wolfgang Maier 3

Part II. Methods in Psychiatric Genetics: Advantages and Limits

2 Analytical Methods Applied to Psychiatric Genetics / Elena L. Grigorenko, David L. Pauls 23

3 Genetic Markers in Psychiatric Genetics / Thomas Bourgeron, Bruno Giros 63

4 Clinical Assessment in Psychiatric Genetics / Philip Gorwood 99

5 Genetic Association Studies: Definition of Cases and Controls / Frank Bellivier 127

Part III. New Phenotypic Approaches

6 Searching for Alternative Phenotypes in Psychiatric Genetics / Marion Leboyer 145

7 Intermediate Cognitive Phenotypes Associated with Schizophrenia / Michael F. Egan, Terry E. Goldberg 163

8 Biochemical Endophenotypes in Personality Disorders / Antonia S. New, Larry J. Siever 199

9 Electrophysiological Phenotypes / Robert Freedman 215

10 Brain Imaging as an Approach to Phenotype Characterization for Genetic Studies of Schizophrenia / Joseph H. Callicott, Daniel R. Weinberger 227

10 Psychiatric Genetics: Future and Prospects / Ming T. Tsuang, Levi Taylor, Stephen V. Faraone 251.

Notes:

Includes bibliographical references and index.

ISBN:

1588290379

OCLC:

49422446