Targeted therapies in rheumatology / Josef S. Smolen, Peter E. Lipsky.

Format:

Book

Author/Creator:

Smolen, Josef S., 1950-

Contributor:

Lipsky, Peter E.

Clarence J. Marshall Memorial Library Fund.

Language:

English

Subjects (All):

Rheumatology--Treatment.

Rheumatology.

Physical Description:

xxi, 729 pages : illustrations ; 26 cm

Place of Publication:

London ; New York : Martin Dunitz ; Independence, KY : Distributed in the USA by Fulfilment Center, Taylor & Francis, 2003.

Summary:

Recent advances in immunology, cell biology, genetics and molecular biology -- as well as clinical success with blockers of the cytokines TNF and IL-1 -- have made it possible to consider truly targeted therapies in the rheumatic diseases for the first time. It is hoped that this book will stimulate a dialogue between basic science, metrology, clinical investigation and biotechnology to foster the development of an appropriate use for the emerging targeted treatments and to search for new pathophysiological targets.

Contents:

Section I. Cells and cell surface receptors

1 T cells / Hendrik Schulze-Koops, Joachim R Kalden 3

2 B cells / Anne Davidson, Konstantin Konstantinov, Betty Diamond 25

3 Macrophages / Peter LEM van Lent, Wim B van den Berg 45

4 Dendritic cells / Ranjeny Thomas, Angus Thompson, Ela Martin, Brendan O'Sullivan 61

5 Mast cells / Peter Valent, Hans-Peter Kiener 83

6 Angiogenesis / Judah Folkman 111

7 Fibroblasts / Sang-Heon Lee, Gary S Firestein 133

8 Origin of the invasive rheumatoid arthritis synovial fibroblasts / John D Mountz, Hui-Chen Hsu, Huang-Ge Zhang 147

9 Complement receptors / V Michael Holers 167

10 Fc receptors / Jane Salmon 181

Section II. Cytokines, chemokines and other effector molecules

11 TNF[alpha] / Marc Feldmann, Ravinder N Maini 201

12 Interleukin-1 / Cem Gabay, William P Arend 213

13 Interleukin-6 / Norihiro Nishimoto, Kazuyuki Yoshizaki, Tadamitsu Kishimoto 231

14 Interleukin-12, Interleukin-23 and Interleukin-27 / Masato Moriguchi, Naresh Chauhan, Alison Finnegan, Warren Strober, David M Frucht, Massimo Gadina, John J O'Shea 243

15 Interleukin-15 / Iain B McInnes, Foo Y Liew 259

16 Interleukin-18 / Charles Dinarello 277

17 Th1/Th2 balance in experimental models of rheumatological diseases / Roberto G Baccala, Dwight H Kono, Argyrios N Theofilopoulos 297

18 Th1/Th2 balance in human disease / Stefano Romagnani, Andrea Matucci, Oliviero Rossi 317

19 The balance between pro- and anti-inflammatory cytokines / Danielle Burger, Jean-Michel Dayer 329

20 Chemokines / Zoltan Szekanecz, Joon Kim, Alisa E Koch 345

21 Osteoprotegerin / Alison R Pettit, Ellen M Gravallese 359

Section III. Transcription factors and signalling molecules

22 NF-[kappa]B / Keith Brown, Estefania Claudio, Ulrich Siebenlist 381

23 Stats and Jaks / Martin Aringer, Wendy Watford, John O'Shea 403

Section IV. Inflammatory mediators

24 Inducible nitric oxide synthase / Steven B Abramson 421

25 Cyclooxygenase and prostaglandin synthase / Leslie J Crofford 439

26 Complement inhibition / M Kathryn Liszewski, John P Atkinson 453

Section V. Matrix molecules

27 Matrix molecules / Michael Sittinger, Iris Leinhase, Gerd Burmester 467

28 Matrix metalloproteinases / Thomas Pap, Steffen Gay, Georg Schett 483

Section VI. Targeted therapies in human and experimental rheumatic diseases

29 Rheumatoid arthritis / Ferdinand C Breedveld 501

30 Early arthritis / Paul Emery 509

31 Juvenile arthritis / Patricia Woo 515

32 Psoriatic arthritis/psoriasis / Philip Mease 525

33 Spondyloarthropathies / Joachim Sieper, Jurgen Braun 549

34 Systemic lupus erythematosus / George A Karpouzas, Bevra H Hahn 563

35 Vasculitis / Gary Hoffman, Leonard H Calabrese, Patrick Liang 583

36 Myositis / Frederick W Miller 603

Section VII. Immunoglobulin manipulation

37 Intravenous immunoglobulin as therapy for RA / Yaniv Sherer, Yehuda Shoenfeld 621

38 Apheresis / Winifried B Graninger 627

Section VIII. Ethics and study design

39 Ethical issues in rheumatologic investigation and practice / Richard S Panush, Arthur Kavanaugh, Paul L Romain 639

40 Randomized controlled trials / Vibeke Strand, Lee S Simon 653

41 Long-term observational studies / Eswar Krishnan, Gurkipal Singh, Peter Tugwell 667

42 Long-term monitoring of novel therapies / Arthur Kavanaugh, John J Cush, Christian Antoni 679

43 Regulatory issues / Jeffrey N Siegel 691.

Notes:

Includes bibliographical references and index.

Local Notes:

Acquired for the Penn Libraries with assistance from the Clarence J. Marshall Memorial Library Fund.

ISBN:

1841841579

OCLC:

50101082