Behavioral genetics in the postgenomic era / edited by Robert Plomin ... [and others].

Format:

Book

Contributor:

Plomin, Robert, 1948-

Language:

English

Subjects (All):

Behavior genetics.

Genetics, Behavioral.

Medical Subjects:

Genetics, Behavioral.

Physical Description:

xxiii, 608 pages : illustrations ; 26 cm

Edition:

First edition.

Place of Publication:

Washington, DC : American Psychological Association, [2003]

Summary:

The Human Genome Project, which has provided a working draft of the sequence of DNA in the human genome, is a remarkable scientific achievement. In this "postgenomic" world, all genes and all DNA variations will eventually be known. For behavioral researchers, this is especially exciting, because behavioral dimensions and disorders are the most complex traits of all. To understand these traits, we need to understand the respective roles of multiple genes and multiple environmental influences.

The goal of this book is to assess where we are and where we are going in genetic research on behavior. The editors have assembled an international group of distinguished contributors who assess progress and promise in both quantitative genetic analysis and molecular genetic analysis of behavior. Particularly significant is a new generation of genetic markers that has made it possible to identify genes for complex quantitative traits. These traits are influenced by multiple genes (QTLs) as well as by multiple environmental factors. The QTL perspective suggests that genetic variation is normal and has implications for thinking about mental illnesses, which has come to be seen as abnormal extremes of quantitative traits.

The book focuses on those aspects of behavior about which behavioral genetics reveals the most. These include cognitive abilities and disabilities, personality, psychopathology, and psychopharmacology. The book will appeal not just to psychologists and psychiatrists but to anyone in the behavioral, biomedical, and biological sciences interested in the genetics of behavior. So great are the implications of behavioral genetics for the practice of psychology in the 21st century that the editors note, "Psychologists will eventually be in the business of preventing the consequences of gene expression."

Contents:

A Behavioral Genetics Perspective / Irving I. Gottesman xiii

A Behavioral Science Perspective / Jerome Kagan xvii

A Molecular Genetics Perspective / James D. Watson xxi

1. Behavioral Genetics / Robert Plomin, John C. DeFries, Ian W. Craig, Peter McGuffin 3

Part II Research Strategies 17

2. The Role of Molecular Genetics in the Postgenomic Era / Ian W. Craig, Joseph McClay 19

3. Recent Developments in Quantitative Trait Loci Analysis / Pak Sham 41

4. Practical Barriers to Identifying Complex Trait Loci / Lon R. Cardon 55

5. Assessing Genotype-Environment Interactions and Correlations in the Postgenomic Era / David C. Rowe 71

6. A U.K. Population Study of Lifestyle and Genetic Influences in Common Disorders of Adult Life / Tom Meade, Frances Rawle, Alan Doyle, Peter Greenaway 87

Part III Learning and Memory in Mice 101

7. Genetic Studies of Learning and Memory in Mouse Models / Jeanne M. Wehner, Seth A. Balogh 103

8. An Integrative Neuroscience Program Linking Mouse Genes to Cognition and Disease / Seth G. N. Grant 123

Part IV Cognitive Abilities 139

9. Genetic Contributions to Anatomical, Behavioral, and Neurophysiological Indices of Cognition / Danielle Posthuma, Eco J. C. de Geus, Dorret I. Boomsma 141

10. Genetic Covariance Between Processing Speed and IQ / Michelle Luciano, Margaret J. Wright, Glen A. Smith, Gina M. Geffen, Laurie B. Geffen, Nicholas G. Martin 163

11. General Cognitive Ability / Robert Plomin 183

Part V Cognitive Disabilities 203

12. Isolation of the Genetic Factors Underlying Speech and Language Disorders / Simon E. Fisher 205

13. Genetic Etiology of Comorbid Reading Difficulties and ADHD / Erik G. Willcutt, John C. DeFries, Bruce F. Pennington, Shelley D. Smith, Lon R. Cardon, Richard K. Olson 227

14. Epistasis and the Genetics of Complex Traits / Elena L. Grigorenko 247

15. The Genetics of Autistic Disorder / Margaret A. Pericak-Vance 267

Part VI Psychopharmacology 289

16. Finding Genes for Complex Behaviors: Progress in Mouse Models of the Addictions / John C. Crabbe 291

17. Genetic and Environmental Risks of Dependence on Alcohol, Tobacco, and Other Drugs / Andrew C. Heath, Pamela A. F. Madden, Kathleen K. Bucholz, Elliot C. Nelson, Alexandre Todorov, Rumi Kato Price, John B. Whitfield, Nicholas G. Martin 309

18. Pharmacogenetics in the Postgenomic Era / Katherine J. Aitchison, Michael Gill 335

Part VII Personality 363

19. Behavioral Genetics, Genomics, and Personality / Richard P. Ebstein, Jonathan Benjamin, Robert H. Belmaker 365

20. Neuroticism and Serotonin: A Developmental Genetic Perspective / K. Peter Lesch 389

21. Animal Models of Anxiety / Jonathan Flint 425

Part VIII Psychopathology 443

22. Attention Deficit Hyperactivity Disorder: New Genetic Findings, New Directions / Anita Thapar 445

23. Schizophrenia and Genetics / Michael J. Owen, Michael C. O'Donovan 463

24. The Genetics of Affective Disorders: Present and Future / Sridevi Kalidindi, Peter McGuffin 481

25. Dementia and Genetics / Julie Williams 503

26. Behavioral Genomics / Robert Plomin, John C. DeFries, Ian W. Craig, Peter McGuffin 531.

Notes:

Includes bibliographical references and indexes.

ISBN:

1557989265

OCLC:

49385843