Glutamate and addiction / edited by Barbara H. Herman ; coeditors, Jerry Frankenheim ... [and others].

Format:

Book

Contributor:

Herman, Barbara H.

Frankenheim, Jerry.

Series:

Contemporary clinical neuroscience

Language:

English

Subjects (All):

Substance abuse--Pathophysiology.

Substance abuse.

Glutamic acid--Physiological effect.

Glutamic acid.

Substance-Related Disorders--physiopathology.

Glutamates--pharmacology.

Receptors, Glutamate--physiology.

Medical Subjects:

Substance-Related Disorders--physiopathology.

Glutamates--pharmacology.

Receptors, Glutamate--physiology.

Physical Description:

xviii, 440 pages, 4 unnumbered pages of plates : illustrations (some color) ; 26 cm.

Place of Publication:

Totowa, N.J. : Humana Press, [2003]

Summary:

In Glutamate and Addiction, world-renowned scientific experts critically review all of the evidence for the role of glutamatergic systems in opiate, stimulant, and alcohol addiction. Using a variety of pharmacological, biochemical, genetic, and brain imaging techniques, these investigators show precisely how glutamate affects such addictions and how modifying certain elements of the glutamatergic system appear to alleviate particular components of addiction. Their survey takes in both clinical approaches using medications that influence glutamate and cutting-edge preclinical approaches that manipulate specific subtypes of glutamate receptors or specific substrates of the "glutamate cascade" to determine their roles in various addictive states.

Contents:

I. Introduction: Physiology and Pharmacology of Glutamate / Philip H. Sheridan, Section Editor, Forrest F. Weight, Section Editor, Barbara H. Herman, Section Editor

1 Molecular Pharmacology and Physiology of Glutamate Receptors / Karin Borges, Raymond Dingledine 3

2 Pharmacology of Glutamate Receptors / Jeffrey M. Witkin, Rafal Kaminski, Michael A. Rogawski 23

3 Glutamate and Neurotoxicity / B. Joy Snider, Dennis W. Choi 51

4 Maturational Regulation of Glutamate Receptors and Their Role in Neuroplasticity / Russell M. Sanchez, Frances E. Jensen 63

5 Role of the NMDA Receptor in Neuronal Apoptosis and HIV-Associated Dementia / Marcus Kaul, Stuart A. Lipton 71

II. Glutamate: Stimulant Drugs of Abuse (Cocaine, Amphetamine, Methamphetamine) / Jerry Frankenheim, Section Editor, Barbara H. Herman, Section Editor

6 Role of Glutamate and Nitric Oxide in the Acquisition and Expression of Cocaine-Induced Conditioned Increases in Locomotor Activity / Agu Pert, Robert M. Post, Susan R. B. Weiss 83

7 Interactions of Dopamine, Glutamate, and GABA Systems in Mediating Amphetamine- and Cocaine-Induced Stereotypy and Behavioral Sensitization / Ralph Karler, David K. Thai, Larry D. Calder 107

8 Addiction and Glutamate-Dependent Plasticity / Marina E. Wolf 127

9 Glutamate and Dopamine Interactions in the Motive Circuit: Implications for Craving / David A. Baker, Jennifer L. Cornish, Peter W. Kalivas 143

10 Glutamate Cascade from Metabotropic Glutamate Receptors to Gene Expression in Striatal Neurons: Implications for Psychostimulant Dependence and Medication / John Q. Wang, Limin Mao, Yuen-Sum Lau 157

11 Glutamate Neurotransmission in the Course of Cocaine Addiction / Luigi Pulvirenti 171

12 Glutamate and the Self-Administration of Psychomotor-Stimulant Drugs / Paul Vezina, Nobuyoshi Suto 183

13 Roles of Glutamate, Nitric Oxide, Oxidative Stress, and Apoptosis in the Neurotoxicity of Methamphetamine / Jean Lud Cadet 201

14 Methamphetamine Toxicity: Roles for Glutamate, Oxidative Processes, and Metabolic Stress / Kristan B. Burrows, Bryan K. Yamamoto 211

15 Nitric Oxide-Dependent Processes in the Action of Psychostimulants / Yossef Itzhak, Julio L. Martin, Syed F. Ali 229

16 Effects of Novel NMDA/Glycine-Site Antagonists on the Blockade of Cocaine-Induced Behavioral Toxicity in Mice / Rae R. Matsumoto, Buddy Pouw 243

17 Clinical Studies Using NMDA Receptor Antagonists in Cocaine and Opioid Dependence / Adam Bisaga, Marian W. Fischman 261

18 The Role of mGluR5 in the Effects of Cocaine: Implications for Medication Development / Mark P. Epping-Jordan 271

III. Glutamate and Opiate Drugs (Heroin) of Abuse / Barbara H. Herman, Section Editor, Jerry Frankenheim, Section Editor

19 Role of the Glutamatergic System in Opioid Tolerance and Dependence: Effects of NMDA Receptor Antagonists / Jianren Mao 281

20 The Role of NMDA Receptors in Opiate Tolerance, Sensitization, and Physical Dependence: A Review of the Research, A Cellular Model, and Implications for the Treatment of Pain and Addiction / Keith A. Trujillo 295

21 Modification of Conditioned Reward by N-Methyl-D-aspartate Receptor Antagonists / Piotr Popik 323

22 Morphine Withdrawal as a State of Glutamate Hyperactivity: The Effects of Glutamate Receptor Subtype Ligands on Morphine Withdrawal Symptoms / Kurt Rasmussen 329

IV. Glutamate and Alcohol Abuse and Alcoholism / Forrest F. Weight, Section Editor, Raye Z. Litten, Section Editor

23 Alcohol Actions on Glutamate Receptors / Robert W. Peoples 343

24 Glutamate and Alcohol-Induced Neurotoxicity / Fulton T. Crews, Joseph G. Rudolph, L. Judson Chandler 357

25 Role of Glutamate in Alcohol Withdrawal Kindling / Howard C. Becker, Nicole Redmond 375

26 Alcohol and Glutamate Neurotransmission in Humans: Implications for Reward, Dependence, and Treatment / John H. Krystal, Ismene L. Petrakis, D. Cyril D'Souza, Graeme Mason, Louis Trevisan 389

27 Mechanism of Action of Acamprosate Focusing on the Glutamatergic System / W. Zieglgansberger, G. Rammes, R. Spanagel, W. Danysz, Ch. Parsons 399

28 The NMDA/Nitric Oxide Synthase Cascade in Opioid Analgesia and Tolerance / Gavril W. Pasternak, Yuri Kolesnikov 409

29 Overview of Clinical Studies for Acamprosate / Adriaan S. Potgieter 417.

Notes:

Includes bibliographical references and index.

ISBN:

0896038793

OCLC:

49221947