Applied electrospray mass spectrometry / edited by Birendra N. Pramanik, A.K. Ganguly, Michael L. Gross.

Format:

Book

Contributor:

Pramanik, Birendra N., 1944-

Ganguly, A. K., 1934-

Gross, Michael L.

Rosengarten Family Fund.

Series:

Practical spectroscopy ; v. 32.

Practical spectroscopy ; v. 32

Language:

English

Subjects (All):

Electrospray ionization mass spectrometry.

Biomolecules--Analysis.

Biomolecules.

Physical Description:

viii, 434 pages : illustrations ; 24 cm.

Place of Publication:

New York : Marcel Dekker, [2002]

Summary:

Discussing strategies to determine the structure and machanisms of numerous compound classics, this book covers new chemical and elctrophoretic techniques for rapid sample preconcentration and separation. It summarizes breakthroughs in the theory and instrumentation of electrospray mass spectrometry in pharmaceutical and biomedical applications, provides practical examples for the characterization of peptides, proteins, and glycoproteins, includes applications in proteomics, combinatorial chemistry, and drug characterization. Topics include chemical and electrophoretic techniques for rapid sample preconcentration and separation, screening processes for proteins from libraries of compounds, protein folding and dynamics, and more.

Contents:

1 Electrospray Ionization Mass Spectrometry: History, Theory, and Instrumentation / Robert B. Cody 1

2 Nanospray Electrospray Ionization Development: LC/MS, CE/MS Application / Tom R. Covey, Devanand Pinto 105

3 Characterization of Pharmaceuticals and Natural Products by Electrospray Ionization Mass Spectrometry / A. K. Ganguly, Birendra N. Pramanik, Guodong Chen, Petia A. Shipkova 149

4 Electrospray Mass Spectrometry Applications in Combinatorial Chemistry / Mike S. Lee 187

5 Electrospray Mass Spectrometry in Contemporary Drug Metabolism and Pharmacokinetics / Mark J. Cole, John S. Janiszewski, Hassan G. Fouda 211

6 Electrospray Mass Spectrometry of Peptides and Proteins: Methodologies and Applications / Joseph A. Loo, Greg W. Kilby 251

7 Structural Analysis of Glycoproteins by Electrospray Ionization Mass Spectrometry / Anthony Tsarbopoulos, Ute Bahr, Birendra N. Pramanik, Michael Karas 283

8 Advanced Mass Spectrometric Approaches for Rapid and Quantitative Proteomics / Richard D. Smith, Gordon A. Anderson, Thomas P. Conrads, Christophe D. Masselon, Mary S. Lipton, Lijljana Pasa Tolic, Timothy D. Veenstra 307

9 Detection of Noncovalent Complexes by Electrospray Ionization Mass Spectrometry / A. K. Ganguly, Birendra N. Pramanik, Guodong Chen, Anthony Tsarbopoulos 361

10 Application of Hydrogen Exchange and Electrospray Ionization Mass Spectrometry in Studies of Protein Structure and Dynamics / Yinsheng Wang, Michael L. Gross 389

11 Microelectrospray Analysis Combined with Microdialysis Sampling of Neuropeptides and Drugs / Per E. Andren, Richard M. Caprioli 411.

Notes:

Includes bibliographical references and index.

Local Notes:

Acquired for the Penn Libraries with assistance from the Rosengarten Family Fund.

ISBN:

0824706188

OCLC:

48691417