Biotherapeutic approaches to asthma / edited by Jan M. Agosti, Albert L. Sheffer.

Format:

Book

Contributor:

Agosti, Jan M., 1955-

Sheffer, Albert L., 1929-

Series:

Lung biology in health and disease ; 167.

Lung biology in health and disease ; 167

Language:

English

Subjects (All):

Asthma--Immunotherapy.

Asthma.

Biological response modifiers.

Asthma--immunology.

Asthma--therapy.

Immunotherapy--methods.

Immunotherapy.

Medical Subjects:

Asthma--immunology.

Asthma--therapy.

Immunotherapy--methods.

Physical Description:

xvi, 466 pages : illustrations ; 24 cm.

Place of Publication:

New York : Dekker, [2002]

Contents:

Part 1 Inhibiting Allergen Sensitization

1. Strategies for the Primary Prevention of Asthma / Fernando D. Martinez 1

II. The Beginnings of Asthma 2

III. Role of Exposure to Allergens 3

IV. Farm Life and Asthma: Exposure to Endotoxin 5

V. Gene by Environment Interaction in the Development of Early Allergic Sensitization 7

VI. Mechanisms of Response to Endotoxin 9

VII. Role of IL-10 and IgG4 Responses 9

VIII. Coexposures to Endotoxin and Their Potential Role 10

2. The Role of Aeroallergens: What Is the Case for Primary Avoidance? / Elizabeth A. Erwin, Thomas A. E. Platts-Mills 17

II. Identification of At-Risk Infants 21

III. The Evidence for In Utero Sensitization 22

IV. Methods of Prevention 23

V. Controlled Trials of Primary Avoidance 26

VI. Other Relevant Allergens 28

Part 2 Inhibiting IgE Response

3. Anti-IgE and the Treatment of Asthma and Allergic Disease / Laura L. Dziadzio, William W. Busse 37

II. IgE Structure, Receptor, and Role in Allergic Disease 38

III. Development of an Anti-IgE Molecule 39

IV. Animal Models Evaluating Anti-IgE 41

V. Human Treatment with Monoclonal Anti-IgE 42

VI. Effects of rhuMAb-E25 on Pulmonary Response to Inhaled Antigen 43

VII. rhuMAb-E25 Effects on Clinical Asthma 45

Part 3 Inhibition of Mast-Cell-Mediator Release or Activity

4. Counterregulation of Cell Activation by the Immunoreceptor Tyrosine-Based Inhibitory Motif / Howard R. Katz 53

II. Fc[gamma]RIIB 54

III. The gp49 Family 55

IV. Paired Ig-Like Receptors (PIRs) 57

V. KIRs and LIRs/ILTs 58

VI. Mast Cell Function-Associated Antigen 59

VII. Conclusions and Implications 60

5. Protease-Activated Receptors, Tryptases, and Mast-Cell-Mediated Immune Responses in the Lung / Richard L. Stevens 69

II. Protease-Activated Receptors 70

III. Mast-Cell Tryptases 79

IV. Gene Linkage Studies Evaluating the Possible Relationship of Protease-Activated Receptors, Tryptases, and Bronchial Hyperresponsiveness 88

V. Future Therapeutic Approaches 89

Part 4 Targeting Proallergic Cytokines

6. Interleukin-4 Inhibition for the Treatment of Asthma / Larry Borish, John W. Steinke, Bruce Davidson, Richard S. Shames, Jan M. Agosti 107

II. Role of IL-4 in the Pathogenesis of Asthma 108

III. Interleukin-4 Signaling 110

IV. IL-4 Genetics and Asthma 112

V. Animal Studies Demonstrating the Role of IL-4 Inhibition in Asthma Therapy 115

VI. Clinical Observations of IL-4 in Allergic Disease 115

VII. Therapeutic Approaches to Neutralizing IL-4 in Asthma 116

VIII. Theoretical Adverse Effects of IL-4 Inhibition 124

7. Immunobiology of Asthma: Biotherapeutic Management / Francis M. Cuss 133

II. Interleukin-5 134

III. Interleukin-9 141

IV. Interleukin-10 144

V. Development of Biological Therapeutic Agents 149

8. Therapeutic Targeting of Chemokines and Chemokine Receptors / Nives Zimmermann, Marc E. Rothenberg 167

II. Chemokine Family 168

III. Chemokine Receptor Family 172

IV. Chemokine and Chemokine Receptor Gene-Deficient Mice 178

V. Pleiotropic Functions of Chemokines in Allergic Responses 181

VI. Chemokines in Animal Models of Allergy 188

VII. Evidence for the Role of Chemokines in Patients with Asthma 190

VIII. Therapeutic Approach to Interfering with Chemokines 191

9. IL-13 Antagonism as a Therapeutic Strategy for the Treatment of Asthma / Marsha Wills-Karp 211

II. Interleukin-13 and Its Receptors 212

III. Biological Actions of IL-13 Relevant to the Allergic Phenotype 215

IV. Role of IL-13 in Experimental Murine Models of Allergic Disease and Efficacy of sIL-13R[alpha]2-Ig 215

V. Potential Mechanisms of IL-13-Induced Allergic Responses 216

VI. IL-13 and Human Asthma 219

VII. Advantages of IL-13 Antagonism in Treatment of Asthma 219

VIII. Therapeutic Approaches to IL-13 Blockade 220

10. Tumor Necrosis Factor [alpha] and Interleukin-1[beta] Inhibitory Therapies / Johan C. Kips, Romain A. Pauwels 225

II. Tumor Necrosis Factor [alpha] 226

III. Interleukin-1[beta] 231

IV. TNF and IL-1[beta] as Targets for Treatment in Asthma 232

Part 5 Inhibition of the Th2 Response

11. Development and Inhibition of Th2 Responses: Realization of Therapeutic Targets / Azzeddine Dakhama, Erwin W. Gelfand 247

II. Th2 Responses in Asthma 248

III. Development of Th1 and Th2 Responses 249

IV. Interference with Th2 Function 256

Part 6 Newer Anti-Inflammatories

12. Cell Adhesion Molecule Blockers and/or Modulators: Potential Therapeutic Tools in Asthma / Theodore F. Reiss, S. Balachandra Dass 293

II. Cell Adhesion Molecules 294

III. Recruitment and Migration of Leukocytes 296

IV. Presence and Expression of Cell Adhesion Molecules in Asthmatic Patients 296

V. Cell Adhesion Molecule Blockers and/or Modulators 297

VI. Clinical Experience 299

Part 7 Role of Allergen-Specific Immunotherapy

13. Allergen-Specific Immunotherapy / A. Barry Kay, Mark Larche 305

II. Specific Allergen Immunotherapy 306

III. Immune Response to Allergen 306

IV. Effects of SIT 307

V. Modulation of the IgE-Dependent Early-Phase Response to Allergen 307

VI. Modulation of T-Cell Responses Following SIT 309

VII. Novel Forms of Immunotherapy 310

VIII. Allergoids 310

IX. Naturally Occurring Allergen Isoforms 311

X. Recombinant Allergens 311

XI. DNA Vaccines 311

XII. Peptide Immunotherapy 312

Part 8 Corticosteroid Effects

14. Glucocorticoid Effects on Mediator Modulation / T. K. Loke, C. J. Corrigan, Tak H. Lee 327

II. Overview of Glucocorticoid Effects 327

III. The Glucocorticoid Receptor 334

IV. The Effects of Glucocorticoids on Gene Transcription 336

V. Mechanisms of Glucocorticoid Resistance in Asthma 339

VI. Molecular Basis of Glucocorticoid-Resistant Asthma 341

Part 9 Summary and Future Directions

15. Future Therapies for Asthma / Peter J. Barnes 353

II. The Future of Existing Therapies 354

III. The Need for New Treatments for Asthma 357

IV. New Corticosteroids 358

V. Mediator Antagonists 359

VI. Anti-Inflammatory Cytokines 363

VII. New Anti-Inflammatory Drugs 364

VIII. Immunomodulators 367

IX. Antiallergy Drugs 368

X. Preventive Strategies 371

XI. Gene Therapy and the Impact of Molecular Genetics 372.

Notes:

Includes bibliographical references and index.

ISBN:

0824707850

OCLC:

49942957