Greenfield's neuropathology.

Format:

Book

Contributor:

Greenfield, J. Godwin (Joseph Godwin), 1884-1958.

Graham, David I.

Lantos, Peter L., 1939-

Language:

English

Subjects (All):

Nervous system--Diseases.

Nervous system.

Nervous System Diseases--pathology.

Medical Subjects:

Nervous System Diseases--pathology.

Physical Description:

2 volumes : illustrations (some color) ; 29 cm

Edition:

Seventh edition / edited by David I. Graham and Peter L. Lantos.

Other Title:

Neuropathology

Place of Publication:

London ; New York : Arnold ; New York, NY : Distributed in the U.S. by Oxford University Press, 2002.

Contents:

Chapter 1 The central neuron / Constantino Sotelo, Antoine Triller 1

Life history of the neuron: the origin of the neuron and its maturation 1

The neuron as a polarized cell 13

The synapse: historical background 30

Chemical synapses 31

Chapter 2 Structure and function of glia in the central nervous system / Martin Berry, Arthur M. Butt, Graham Wilkin, V. Hugh Perry 75

Macroglia 75

Microglia 104

Chapter 3 Cellular pathology of the central nervous system / Manuel B. Graeber, William F. Blakemore, Georg W. Kreutzberg 123

The neuron 123

Reaction and responses of oligodendrocytes to injury 137

Astrocytes 151

Ependyma 157

Microglia 158

Perivascular cells and other brain macrophages 171

Effects of irradiation on the nervous system 172

Artefacts 173

Chapter 4 Raised intracranial pressure, oedema and hydrocephalus / James W. Ironside, John D. Pickard 193

Raised intracranial pressure 195

Effects of changes in cerebral blood volume and CSF pressure 196

Intracranial pressure-volume relationships 197

The blood-brain barrier 200

Brain swelling and oedema 203

The pathology of intracranial expanding lesions 209

Other cranial effects of raised ICP 216

Hydrocephalus 217

Chapter 5 Hypoxia and related conditions / Roland N. Auer, Garnette R. Sutherland 233

Oxygen delivery and metabolism 234

Classification of hypoxia 239

Carbon monoxide poisoning 249

Air embolism and decompression sickness 250

Selective neuronal necrosis 251

Ischaemic neuroprotection 258

Hypoglycaemic brain damage 260

Selective vulnerability 262

Chapter 6 Vascular diseases / Hannu Kalimo, Markku Kaste, Matti Haltia 281

Development and anatomy 281

Definitions and epidemiology of vascular disorders of the central nervous system 286

Diseases affecting the blood vessels 288

Haematological disorders 317

Consequences of cerebrovascular disorders 321

Chapter 7 Malformations / Brian N. Harding, Andrew J. Copp 357

Principles of nervous system development 357

A guide to interpreting the pathogenesis of malformations 374

Pathology of malformations 376

Chapter 8 Metabolic and neurodegenerative diseases of childhood / Brian N. Harding, Robert Surtees 485

Grey-matter disorders 485

Inborn errors of intermediary metabolism 501

Chapter 9 Perinatal neuropathology / Hannah C. Kinney, Dawna Duncan Armstrong 519

Brain growth 520

Cellular reactions in the developing human CNS 521

Toxic and metabolic damage 535

Grey-matter lesions 536

White-matter lesions 543

Combined grey- and white-matter Lesions 551

Hypoglycaemia 555

Cerebral haemorrhages 557

Infection 560

Trauma 563

Child abuse 567

Neoplasia 570

Musculoskeletal disorders 573

Spinal muscular and neurogenic atrophies 580

Arthrogryposis multiplex congenita 581

Sudden infant death syndrome 583

Neuropathology of the stillborn 586

Chapter 10 Nutritional and metabolic disorders / Clive Harper, Roger Butterworth 607

Malnutrition 607

Vitamin deficiencies 609

Systemic disorders 632

Inherited metabolic defects 637

Chapter 11 Lysosomal diseases / Kinuko Suzuki, Kunihiko Suzuki 653

Sphingolipidoses 653

Mucopolysaccharidoses 683

Glycoprotein disorders 693

Neuronal ceroid lipofuscinosis (NCL, Batten's disease) 700

Miscellaneous lysosomal disorders 708

Chapter 12 Peroxisomal and mitochondrial disorders / James M. Powers, Darryl C. De Vivo 737

Peroxisomes and peroxisomal disorders 738

Mitochondria and mitochondrial disorders 758

Chapter 13 Neurotoxicology / Doyle Graham, Thomas J. Montine 799

Neurotoxicants 799

Neurotoxins 801

Biochemical mechanisms of selected neurotoxicants 810

Toxicants as risk factors for neurological disease 814

Chapter 14 Trauma / David I. Graham, Tom A. Gennarelli, Tracy K. McIntosh 823

Blunt head injury 824

Chapter 15 Epilepsy / Mrinalini Honavar, Brian S. Meldrum 899

Classification 899

Epidemiology 900

Death in epilepsy 901

Genetics 902

Symptomatic epilepsy 904

Changes secondary to epilepsy 912

Myoclonus epilepsy 922

Neurosurgery and neurosurgical pathology 924

Chapter 16 Ophthalmic neuropathology / Philip J. Luthert, Susan Lightman 943

Developmental abnormalities 944

Trauma 949

Vascular disease 955

Inflammatory and immune disease 959

Degenerative disease 963

Chapter 17 Hypothalamus and pituitary / Eva Horvath, Bernd W. Scheithauer, Kalman Kovacs, Ricardo V. Lloyd 983

Morphology and hormones of the normal hypothalamus and pituitary 983

Pathology of the hypothalamus and pituitary 1002

Chapter 18 Regional neuropathology: diseases of the spinal cord and vertebral column / Umberto De Girolami, Matthew P. Frosch, Charles H. Tator 1063

Vascular disease of the spinal cord 1063

Compression of the spinal cord 1073

Diseases of the vertebral column affecting the spinal cord 1074

Trauma 1082

Chapter 1 Viral diseases / Seth Love, Clayton A. Wiley 1

Acute viral infections 10

Subacute and chronic viral infections 50

Subacute measles encephalitides 51

Chapter 2 Parasitic and fungal diseases / Gareth Turner, Francesco Scaravilli 107

Protozoal infections 107

Metazoal infections 121

Infections by fungi 132

Chapter 3 Bacterial infections of the central nervous system / Francoise Gray, Jean-Michel Alonso 151

Anatomy 151

Pathogenesis of bacterial infection 152

Predisposing factors to bacterial infections 156

Pyogenic infections 156

Actinomycetal infections 171

Spirochaetal infections 178

Brucellosis 185

Mycoplasma infections 185

Sarcoidosis 186

Toxin-induced neurological disease 187

Chapter 4 Ageing and dementia / Suzanne S. Mirra, Bradley T. Hyman 195

Ageing of the brain 195

Dementia 198

Alzheimer's disease 200

Tau-associated disorders (tauopathies) 226

Other frontotemporal dementias 233

Disorders with Lewy bodies 235

ALS-parkinsonism-dementia complex 239

Familial dementia associated with neuroserpin mutations 240

Thalamic dementia 241

Vascular dementia 241

Familial disorders with CAA 245

Normal pressure hydrocephalus 246

Chapter 5 Prion diseases / Stephen J. DeArmond, Hans A. Kretzschmar, Stanley B. Prusiner 273

Prion diseases in animals 278

Prion diseases in man 280

Molecular classification of CJD-like diseases: human prion strains 299

Definitive diagnosis of CJD and FI 301

Myopathies related to the prion protein 305

Prion biology 306

Mechanisms of nerve cell dysfunction, degeneration and death 313

Risk of prion disease to health-care workers 316

Chapter 6 Disorders of movement and system degenerations / James S. Lowe, Nigel Leigh 325

Anatomy and function of basal ganglia 328

Trauma and movement disorders 329

Akinetic rigid movement disorders 329

Hyperkinetic movement disorders 351

Degenerative ataxic disorders 359

Motor neuron disorders 372

Miscellaneous disorders affecting the basal ganglia 388

Abnormalities of central autonomic systems 394

Chapter 7 Neuropathology of psychiatric disorders / Margaret M. Esiri, Tim J. Crow 431

Categories and dimensions: the kraepelinian dichotomy of psychosis and the significance of schneiderian symptoms 431

Schizophrenic psychoses 432

Affective psychoses 453

Other disorders 455

Chapter 8 Demyelinating diseases / John W. Prineas, W. Ian McDonald, Robin J.M. Franklin 471

Multiple sclerosis 472

Rabies postvaccinal encephalomyelitis 526

Acute haemorrhagic Leukoencephalitis (Hurst's disease) 527

Experimental and naturally occurring demyelinating diseases in animals 530

Models of demyelination 531

Chapter 9 Peripheral nerves / Peter J. Dyck, P. James B. Dyck, Caterina Giannini, Zarife Sahenk, Anthony J.

Windebank, JaNean Engelstad

Normal structure of the peripheral nervous system 551

Neurobiology 561

Nerve biopsy 572

Teased fibres 573

Morphometry and stereology of neurons 578

Inadequate histogical preparations and artefacts 580

Clinical anatomicopathological patterns of neuropathy helpful in differential diagnosis 582

Overview of the basis and classification of fibre alteration 582

Axonal nerve fibre alterations 587

Schwann cell alterations 602

Perineurial alterations 603

Epineurial alterations 605

Nerve injury and repair 605

Infection 608

Inflammation and altered immunity 615

Inherited neuropathies 628

Metabolic neuropathies 639

Toxic neuropathies 646

Ischaemic and hypoxic injury of nerves 653

Carcinoma, lymphocyte and plasma cell proliferative disease, leukaemia and paraneoplastic neuropathy 658

Chapter 10 Diseases of muscle / Roy O. Weller, William J.K. Cumming, Mike Mahon, David W. Ellison 677

Normal muscle 681

General pathology of muscle disease 693

Clinical aspects of neuromuscular disease 701

Pathology of specific muscle diseases 707

Neurogenic muscle diseases 708

Disorders of neuromuscular transmission 715

Primary muscle diseases: myopathies 717

Chapter 11 Tumours of the nervous system / Peter L. Lantos, David N. Louis, Marc K. Rosenblum, Paul Kleihues 767

Epidemiology and aetiology 767

Experimentally induced tumours 772

Classification and grading 779

Tumours of the neuroepithelial tissue 782

Tumours of the peripheral nerves 897

Hereditary tumour syndromes 935

Germ-cell tumours 944

Lymphomas 950

Chordomas 960

Cysts and tumour-like conditions 964

Metastatic tumours 971

Paraneoplastic syndromes 975.

Notes:

Includes bibliographical references and indexes.

ISBN:

0340742313

OCLC:

47063157