Xenotransplantation : basic research and clinical applications / edited by Jeffrey L. Platt.

Format:

Book

Contributor:

Platt, Jeffrey L.

Language:

English

Subjects (All):

Xenografts.

Transplantation, Heterologous.

Transplantation Immunology.

Medical Subjects:

Transplantation, Heterologous.

Transplantation Immunology.

Physical Description:

x, 270 pages : illustrations ; 24 cm

Place of Publication:

Totowa, NJ : Humana Press, 2002.

Summary:

Internationally recognized scientists, clinicians, and technologists review and explain the fundamental molecular and cellular biology that has been applied to the emerging field of transplant immunology and xenotransplantation, and what impact these advances might optimally have on medicine and science. The authoritative experts writing here-many of whom made the basic discoveries underlying the recent advances-examine the biological and immunological hurdles to xenotransplantation, illuminating how the immune system interacts with the xenograft and laying a practical foundation for the use of genetic engineering and animal transplants in the treatment of human disease.

Contents:

1 Molecular and Cellular Hurdles to Xenotransplantation / Jeffrey L. Platt 1

2 Pathological Responses to Xenotransplantation / Matilde Bustos, Jeffrey L. Platt 45

3 Natural Xenoreactive Antibodies / Uri Galili 57

4 Specificity of Xenoreactive Natural Antibodies / William Parker, Paul B. Yu, Yuko C. Nakamura 73

5 Biophysical Properties of Xenoreactive Natural Antibodies / William Parker, Ryan C. Fields, Yuko C. Nakamura 87

6 The Origin of Xenoreactive Natural Antibodies / Paul B. Yu 103

7 Synthesis of Carbohydrate Antigens Recognized by Xenoreactive Antibodies / Mauro S. Sandrin, Ian F. C. McKenzie 119

8 The Complement Barrier to Xenotransplantation / Agustin P. Dalmasso 139

9 Defects and Amplification of Costimulation Across the Species / Nicola Rogers, Robert Lechler 173

10 Antibody-Dependent Effects on Cellular Immunity / Antonello Pileggi, R. Damaris Molano, Thierry Berney, Luca Inverardi 199

11 Disordered Regulation of Coagulation and Platelet Activation in Xenotransplantation / Simon C. Robson 215

12 Current Applications of Cellular Xenografts / Albert S. B. Edge 247.

Notes:

Includes bibliographical references and index.

ISBN:

089603674X

OCLC:

48162845