Do seizures damage the brain / edited by Thomas Sutula, Asla Pitkänen.

Format:

Book

Contributor:

Sutula, Thomas.

Pitkänen, Asla.

Series:

Progress in brain research ; v. 135.

Progress in brain research ; v. 135

Language:

English

Subjects (All):

Convulsions--Pathophysiology.

Convulsions.

Epilepsy--Complications.

Epilepsy.

Brain--Pathophysiology.

Brain.

Epilepsy--complications.

Seizures--physiopathology.

Brain--physiopathology.

Physiology, Pathological.

Medical Subjects:

Epilepsy--complications.

Seizures--physiopathology.

Brain--physiopathology.

Physical Description:

xix, 520 pages : illustrations (some color) ; 27 cm.

Edition:

First edition.

Place of Publication:

Amsterdam ; Boston : Elsevier, 2002.

Summary:

People with severe epilepsy may experience multiple seizures each day and hundreds to thousands during the course of a lifetime. For many patients, recurring seizures become increasingly frequent and are associated with progressive disability that may include memory loss, cognitive impairments, and diminished quality of life. This book seeks to answer the question, "Do seizures damage the brain?" using a variety of methods in experimental models and in patients with epilepsy.

Contents:

Section I. Seizure-induced damage in experimental epilepsy

1. Concept of activity-induced cell death in epilepsy: historical and contemporary perspectives / B.S. Meldrum 3

2. Are seizures harmful: what can we learn from animal models? / A.J. Cole, S. Koh, Y. Zheng 13

3. Doubt and certainty in counting / R.W. Guillery, B.K. August 25

4. Design-based stereological methods for counting neurons / M.J. West 43

5. The course of cellular alterations associated with the development of spontaneous seizures after status epilepticus / F.E. Dudek, J.L. Hellier, P.A. Williams, D.J. Ferraro, K.J. Staley 53

6. Progression of neuronal damage after status epilepticus and during spontaneous seizures in a rat model of temporal lobe epilepsy / A. Pitkanen, J. Nissinen, J. Nairismagi, K. Lukasiuk, O.H.J. Grohn, R. Miettinen, R. Kauppinen 67

7. Does convulsive status epilepticus (SE) result in cerebral damage or affect the course of epilepsy

the epidemiological and clinical evidence? / S. Shorvon 85

8. Repeated brief seizures induce progressive hippocampal neuron loss and memory deficits / R. Kotloski, M. Lynch, S. Lauersdorf, T. Sutula 95

9. Neuronal apoptosis after brief and prolonged seizures / J. Bengzon, P. Mohapel, C. Ekdahl, O. Lindvall 111

10. Seizure-induced neurogenesis: are more new neurons good for an adult brain? / J.M. Parent, D.H. Lowenstein 121

11. Summary: Seizure-induced damage in experimental models / T. Sutula, A. Pitkanen 133

Section II. Mechanisms of seizure-induced damage

12. Complications associated with genetic background effects in models of experimental epilepsy / P.E. Schauwecker 139

13. Genomics and neurological phenotypes: applications for seizure-induced damage / J.A. Del Rio, C. Barlow 149

14. Functional genomics in experimental and human temporal lobe epilepsy: powerful new tools to identify molecular disease mechanisms of hippocampal damage / A.J. Becker, O.D. Wiestler, I. Blumcke 161

15. What synaptic lipid signaling tells us about seizure-induced damage and epileptogenesis / N.G. Bazan, B. Tu, E.B. Rodriguez de Turco 175

16. The role of mitochondria and oxidative stress in neuronal damage after brief and prolonged seizures / H.R. Cock 187

17. Cell death and metabolic activity during epileptiform discharges and status epilepticus in the hippocampus / U. Heinemann, K. Buchheim, S. Gabriel, O. Kann, R. Kovacs, S. Schuchmann 197

18. Summary: Mechanisms of seizure-induced damage / T. Sutula, A. Pitkanen 211

Section III. Evidence for seizure-induced damage in human studies: epidemiology, pathology, imaging and clinical studies

19. Do seizures beget seizures? / W.A. Hauser, J.R. Lee 215

20. Do occasional brief seizures cause detectable clinical consequences? / S. Shinnar, W.A. Hauser 221

21. Hippocampal neuron damage in human epilepsy: Meyer's hypothesis revisited / G.W. Mathern, P.D. Adelson, L.D. Cahan, J.P. Leite 237

22. MRI studies. Do seizures damage the brain? / J.S. Duncan 253

23. Do prolonged febrile seizures produce medial temporal sclerosis? Hypotheses, MRI evidence and unanswered questions / D.V. Lewis, D. Barboriak, J.R. MacFall, J.M. Provenzale, T.V. Mitchell, K.E. VanLandingham 263

24. Do recurrent seizures cause neuronal damage? A series of studies with MRI volumetry in adults with partial epilepsy / R. Kalviainen, T. Salmenpera 279

25. Proton magnetic resonance spectroscopic imaging suggests progressive neuronal damage in human temporal lobe epilepsy / A. Bernasconi, E. Tasch, F. Cendes, L.M. Li, D.L. Arnold 297

26. Neuroimaging and the progression of epilepsy / W.H. Theodore, W.D. Gaillard 305

27. Summary: Evidence for seizure-induced damage in human studies: epidemiology, pathology, imaging, and clinical studies / T. Sutula, A. Pitkanen 315

Section IV. Seizure-induced cell death in development and functional consequences

28. Seizure-induced damage in the developing human: relevance of experimental models / G.L. Holmes, R. Khazipov, Y. Ben-Ari 321

29. Seizure-induced neuronal death in the immature brain / C.G. Wasterlain, J. Niquet, K.W. Thompson, H. Liu, R. Sankar, A.M. Mazarati, D. Naylor, H. Katsumori, L. Suchomelova, Y. Shirasaka 335

30. Effects of brief seizures during development / L. Velisek, S.L. Moshe 355

31. Is neuronal death required for seizure-induced epileptogenesis in the immature brain? / T.Z. Baram, M. Eghbal-Ahmadi, R.A. Bender 365

32. Assessing the behavioral and cognitive effects of seizures on the developing brain / C.E. Stafstrom 377

33. Recent experimental studies of the effects of seizures on brain development / J.W. Swann 391

34. Summary: Seizure-induced damage in development and functional consequences / T. Sutula, A. Pitkanen 395

Section V. Neuropsychological consequences of human epilepsy

35. Progressive cognitive decline in adolescents and adults with epilepsy / C.B. Dodrill 399

36. Progressive cognitive decline in epilepsy: an indication of ongoing plasticity / H. Stefan, E. Pauli 409

37. Progressive behavioral changes in children with epilepsy / J.K. Austin, D.W. Dunn 419

38. The neurodevelopmental impact of childhood onset temporal lobe epilepsy on brain structure and function and the risk of progressive cognitive effects / B.P. Hermann, M. Seidenberg, B. Bell 429

39. Effects of chronic epilepsy on declarative memory systems / C. Helmstaedter 439

40. Effects of chronic epilepsy on intellectual functions / H. Jokeit, A. Ebner 455

41. Summary: neuropsychological consequences of human epilepsy / T. Sutula, A. Pitkanen 465

Section VI. Implications for management

42. Will brain damage after status epilepticus be history in 2010? / D.M. Treiman 471

43. Is complete seizure control imperative? / F. Andermann 479

44. Implications for neuroprotective treatments / B.S. Meldrum 487

45. Development of neuroprotective compounds in the pharmaceutical industry: Where are we, and where are we going? / N. Santilli 497

46. So what can we conclude

do seizures damage the brain? / J. Engel Jr. 509

47. Summary: Implications for management / T. Sutula, A. Pitkanen 513.

Notes:

Includes bibliographical references and index.

ISBN:

0444508147

OCLC:

48761736