High dose chemotherapy : principles and practice / edited by Paul Lorigan, Elisabeth Vandenberghe.

Format:

Book

Contributor:

Lorigan, Paul.

Vandenberghe, Elisabeth.

Language:

English

Subjects (All):

Drug Therapy.

Dose-Response Relationship, Drug.

Hematopoietic Stem Cell Transplantation.

Cancer--Chemotherapy.

Cancer.

Hematopoietic growth factors--Therapeutic use.

Hematopoietic growth factors.

Drugs--Dosage.

Drugs.

Medical Subjects:

Drug Therapy.

Dose-Response Relationship, Drug.

Hematopoietic Stem Cell Transplantation.

Physical Description:

x, 331 pages : illustrations ; 25 cm

Place of Publication:

London : Martin Dunitz ; Florence, KY, USA : Distributed in the USA by Fulfilment Center Taylor & Francis, [2002]

Summary:

This text presents an overview of the basic science and principles of high dose chemotherapy, current state-of-the-art techniques and future developments such as gene therapy. The main section of the book is disease-based, setting the scientific principles within a clinical context and reviewing the application of high dose therapy in specific diseases. Additional sections discuss supportive care and long-term complications. High Dose Chemotherapy is directed at hematologists, clinical and medical oncologists in training or with an interest, rather than direct involvement, in the field.

Contents:

Part 1 Scientific basis of high dose chemotherapy

1. Haemopoisis and isolation of stem cells / Erica A de Wynter, T Michael Dexter, Nydia G Testa 3

2. Pharmacology and principles of high dose chemotherapy / Miguel Hernandez-Bronchud, Rhoda Molife 15

3. Purging, selection and minimal residual disease / Gunnar Kvalheim 29

4. Leukapheresis and mobilization / Ruth Pettengell 41

Part 2 High dose chemotherapy in specific diseases

5. Autologous transplantation in acute leukaemia / Joanne Ewing, Rajesh Chopra 61

6. Autografting with mobilized hematopoietic progenitor cells in chronic myeloid leukemia / Angelo Michele Carella, Enrica Lerma, Germana Beltrami, Maria Teresa Corsetti 83

7. High dose chemotherapy in multiple myeloma / Jean-Luc Harousseau 91

8. High dose chemotherapy and stem cell rescue in the treatment of low-grade non-Hodgkin's lymphoma / Elisabeth Vandenberghe 105

9. High dose chemotherapy and stem cell transplantation in Hodgkin's disease / John W Sweetenham 115

10. High dose chemotherapy in aggressive lymphomas / Bertrand Coiffier, Gilles Salles 127

11. High dose chemotherapy in ovarian cancer / Jonathan A Ledermann, Ruth Herd 143

12. High dose chemotherapy in breast cancer / John Crown 157

13. High dose chemotherapy in sarcomas: science, fiction or science fiction? / Caroline Seynaeve, Jaap Verweij 167

14. Dose intensification and small cell lung cancer / Rhada Bhaskaran, Mark Middleton, Paul Burt, Ron Stout, Nicholas Thatcher 181

15. High dose chemotherapy in germ cell tumours / Jonathan Shamash, R Timothy D Oliver 197

Part 3 Supportive care and long-term complications

16. Blood products and supportive care / Mike Leach 211

17. Infections following high dose chemotherapy / Beryl A Oppenheim 223

18. High dose chemotherapy and gonadal function / Simon J Howell, Stephen M Shalet 237

19. Long-term complications after high dose chemotherapy and hematopoietic cell transplantation / H Joachim Deeg 249

20. Overview of allogeneic procedures: immune modulation and non-myeloablative allogeneic hematopoietic stem cell transplantation / George E Georges, Rainer F Storb 267

Part 4 Current and future developments

21. Gene therapy of cancer / Stephen Devereux 289

22. Cost-effectiveness of high dose chemotherapy in non-Hodgkin's lymphoma, Hodgkin's disease and multiple myeloma / Fiona Sampson, Stephen Beard, Paul Lorigan 305

23. High dose chemotherapy in the new millennium / Thierry Philip, Ross Pinkerton 319.

Notes:

Includes bibliographical references and index.

ISBN:

9058232328

OCLC:

50339974