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The genetics and biology of sex determination / [editors, Derek Chadwick, Jamie Goode].
Holman Biotech Commons R850.A2 N69 v.244 2002
Available
- Format:
- Book
- Series:
- Novartis Foundation symposium ; 244.
- Novartis Foundation symposium ; 244
- Language:
- English
- Subjects (All):
- Genetic sex determination--Congresses.
- Genetic sex determination.
- Sex Determination Processes.
- Medical Subjects:
- Sex Determination Processes.
- Genre:
- Conference papers and proceedings.
- Physical Description:
- ix, 266 pages : illustrations ; 24 cm.
- Place of Publication:
- New York : John Wiley, 2002.
- Summary:
- Nature employs a wide variety of sex determining mechanisms and it is only comparatively recently that the tools have become available for these to be explored at the cellular and molecular levels. A major landmark was the discovery in 1990 of the "SRY" gene and the subsequent demonstration of its key role in triggering male sex determination in transgenic mice.
- This book reviews and discusses our current understanding of the molecular genetic pathways of sex determination, with special emphasis on vertebrates. It features comparisons with other modes of sex determination, consideration of the biology of sexual development and discussion of the evolution of sex-determining mechanisms.
- By bringing together an international and interdisciplinary group of experts who study many different aspects of the problem, the book highlights much new and exciting work in this area and serves to identify and stimulate promising new research directions.
- Contents:
- Chair's introduction / Roger V. Short 1
- Sex-determining genes in mice: building pathways / Robin Lovell-Badge, Clare Canning, Ryohei Sekido 4
- Early gonadal development: exploring Wt1 and Sox9 function / Jian-Kan Guo, Annette Hammes, Marie-Christine Chaboissier, Valerie Vidal, Yiming Xing, Frances Wong, Andreas Schedl 23
- General discussion I The mechanism of action of SRY 35
- Anomalies of human sexual development: clinical aspects and genetic analysis / Eric Vilain 43
- The molecular action of testis-determining factors SRY and SOX9 / Vincent R. Harley 57
- Concerted regulation of gonad differentiation by transcription factors and growth factors / Taiga Suzuki, Hirofumi Mizusaki, Ken Kawabe, Megumi Kasahara, Hidefumi Yoshioka, Ken-ichirou Morohashi 68
- Evolution of the testis-determining gene
- the rise and fall of SRY / Jennifer A. Marshall Graves 86
- A comparative analysis of vertebrate sex determination / Andrew Sinclair, Craig Smith, Patrick Western, Peter McClive 102
- Invertebrates may not be so different after all / David Zarkower 115
- The hormonal control of sexual development / Marilyn B. Renfree, Jean D. Wilson, Geoffrey Shaw 136
- Genetic studies of MIS signalling in sexual development / Soazik P. Jamin, Nelson A. Arango, Yuji Mishina, Richard R. Behringer 157
- Social regulation of the brain: sex, size and status / Russell D. Fernald 169
- The battle of the sexes: opposing pathways in sex determination / Humphrey Hung-Chang Yao, Christopher Tilmann, Guang-Quan Zhao, Blanche Capel 187
- General discussion III True hermaphroditism and the formation of the ovotestis 203
- The evolution of chromosomal sex determination / Brian Charlesworth 207
- The molecular genetic jigsaw puzzle of vertebrate sex determination and its missing pieces / Gerd Scherer 225
- Expression-based strategies for discovery of genes involved in testis and ovary development / Peter Koopman, Monica Bullejos, Kelly Loffler, Josephine Bowles 240.
- Notes:
- Includes bibliographical references and indexes.
- ISBN:
- 0470843462
- OCLC:
- 48449511
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