Protein expression in Down Syndrome brain / G. Lubec, ed.

Format:

Book

Contributor:

Lubec, Gert.

Series:

Journal of neural transmission. Supplementum ; 61.

[Journal of neural transmission. Supplement, 0303-6995 ; 61]

Language:

English

Subjects (All):

Down syndrome--Patients--Physiology.

Down syndrome.

Brain--Physiology.

Brain.

Proteins.

Down Syndrome--physiopathology.

Brain--physiopathology.

Gene Expression Regulation.

Nerve Tissue Proteins.

Down syndrome--Patients.

Physiology.

Medical Subjects:

Down Syndrome--physiopathology.

Brain--physiopathology.

Gene Expression Regulation.

Nerve Tissue Proteins.

Physical Description:

x, 371 pages : illustrations ; 28 cm.

Place of Publication:

Wien ; New York : Springer, [2001]

Contents:

Decreased alpha-endosulfine, an endogenous regulator of ATP-sensitive potassium channels, in brains from adult Down syndrome patients / S. H. Kim, G. Lubec 1

Developmental instability of the cerebellum and its relevance to Down syndrome / B. L. Shapiro 11

Expression of the multidrug resistance P glycoprotein (Pgp) and multidrug resistance associated protein (MRP1) in Down syndrome brains / E. Engidawork, J. C. Roberts, R. Hardmeier, R. J. Scheper, G. Lubec 35

Deterioration of the transcriptional, splicing and elongation machinery in brain of fetal Down Syndrome / M. Freidl, T. Gulesserian, G. Lubec, M. Fountoulakis, B. Lubec 47

Fetal life in Down Syndrome starts with normal neuronal density but impaired dendritic spines and synaptosomal structure / R. Weitzdoerfer, M. Dierssen, M. Fountoulakis, G. Lubec 59

Antioxidant proteins in fetal brain: superoxide dismutase-1 (SOD-1) protein is not overexpressed in fetal Down syndrome / T. Gulesserian, E. Engidawork, M. Fountoulakis, G. Lubec 71

Glial-neurotrophic mechanisms in Down syndrome / P. G. Nelson, S. K. McCune, A. M. Ades, K. B. Nelson 85

Aberrant expression of dihydropyrimidinase related proteins-2, -3 and -4 in fetal Down Syndrome brain / R. Weitzdoerfer, M. Fountoulakis, G. Lubec 95

Decreased protein levels of complex I 30-kDa subunit in fetal Down Syndrome brains / S. H. Kim, M. Fountoulakis, M. Dierssen, G. Lubec 109

Selective upregulation of the ubiquitin-proteasome proteolytic pathway proteins, proteasome zeta chain and isopeptidase T in fetal Down syndrome / E. Engidawork, J.-F. Juranville, M. Fountoulakis, M. Dierssen, G. Lubec 117

Functional genomics of Down Syndrome: a multidisciplinary approach / M. Dierssen, E. Marti, C. Pucharcos, V. Fotaki, X. Altafaj, K. Casas, A. Solans, M. L. Arbones, C. Fillat, X. Estivill 131

Unaltered expression of Fas (CD95/APO-1), Caspase-3, Bcl-2 and Annexins in brain of fetal Down syndrome: evidence against increased apoptosis / E. Engidawork, N. Balic, J.-F. Juranville, M. Fountoulakis, M. Dierssen, G. Lubec 149

Alteration of caspases and other apoptosis regulatory proteins in Down syndrome / T. Gulesserian, E. Engidawork, B. C. Yoo, N. Cairns, G. Lubec 163

Expression of apoptosis related proteins: RAIDD, ZIP kinase, Bim/BOD, p21, Bax, Bcl-2 and NF-[kappa]B in brains of patients with Down syndrome / E. Engidawork, T. Gulesserian, R. Seidl, N. Cairns, G. Lubec 181

Increased brain protein levels of carbonyl reductase and alcohol dehydrogenase in Down Syndrome and Alzheimer's disease / B. Balcz, L. Kirchner, N. Cairns, M. Fountoulakis, G. Lubec 193

Carbohydrate handling enzymes in fetal Down Syndrome brain / E. Kitzmueller, S. Greber, M. Fountoulakis, G. Lubec 203

Changes in nicotinic acetylcholine receptor subunits expression in brain of patients with Down syndrome and Alzheimer's disease / E. Engidawork, T. Gulesserian, N. Balic, N. Cairns, G. Lubec 211

Protein levels of human peroxiredoxin subtypes in brains of patients with Alzheimer's disease and Down Syndrome / S. H. Kim, M. Fountoulakis, N. Cairns, G. Lubec 223

Effects of a single transdermal nicotine dose on cognitive performance in adults with Down syndrome / G. Bernert, M. Sustrova, E. Sovcikova, R. Seidl, G. Lubec 237

The brain in Down syndrome / R. Seidl, N. Cairns, G. Lubec 247

Decreased levels of ARPP-19 and PKA in brains of Down syndrome and Alzheimer's disease / S. H. Kim, A. C. Nairn, N. Cairns, G. Lubec 263

Increased protein levels of heterogeneous nuclear ribonucleoprotein A2/B1 in fetal Down syndrome brains / S. H. Kim, M. Dierssen, J. C. Ferreres, M. Fountoulakis, G. Lubec 273

Decreased protein levels of stathmin in adult brains with Down syndrome and Alzheimer's disease / M. S. Cheon, M. Fountoulakis, N. J. Cairns, M. Dierssen, K. Herkner, G. Lubec 281

Molecular neuropathology of transgenic mouse models of Down syndrome / N. J. Cairns 289

Down syndrome patients start early prenatal life with normal cholinergic, monoaminergic and serotoninergic innervation / B. Lubec, B. C. Yoo, M. Dierssen, N. Balic, G. Lubec 303

Expression profiles of proteins in fetal brain with Down syndrome / M. S. Cheon, M. Fountoulakis, M. Dierssen, J. C. Ferreres, G. Lubec 311

Expression patterns of chaperone proteins in cerebral cortex of the fetus with Down Syndrome: dysregulation of T-complex protein 1 / B. C. Yoo, M. Fountoulakis, M. Dierssen, G. Lubec 321

[beta]-Amyliod precursor protein, ETS-2 and collagen alpha 1 (VI) chain precursor, encoded on chromosome 21, are not overexpressed in fetal Down syndrome: further evidence against gene dosage effect / E. Engidawork, N. Balic, M. Fountoulakis, M. Dierssen, S. Greber-Platzer, G. Lubec 335

Reduction of nucleoside diphosphate kinase B, Rab GDP-dissociation inhibitor beta and histidine triad nucleotide-binding protein in fetal Down Syndrome brain / R. Weitzdoerfer, D. Stolzlechner, M. Dierssen, J. Ferreres, M. Fountoulakis, G. Lubec 347

Alteration of gene expression in Down's syndrome (DS) brains: its significance in neurodegeneration / A. Sawa 361.

Notes:

Includes bibliographical references.

ISBN:

3211837043

3211837329

OCLC:

50590846