Assessing oral bioavailability of metals in soils / by Mark E. Kelley ... [and others].

Format:

Book

Contributor:

Kelley, Mark E., 1960-

Language:

English

Subjects (All):

Health risk assessment--Handbooks, manuals, etc.

Health risk assessment.

Bioavailability--Handbooks, manuals, etc.

Bioavailability.

Metals--Environmental aspects--Handbooks, manuals, etc.

Metals.

Metals--Health aspects--Handbooks, manuals, etc.

Hazardous wastes--Risk assessment--Handbooks, manuals, etc.

Hazardous wastes.

Hazardous wastes--Risk assessment.

Metals--Health aspects.

Metals--Environmental aspects.

Genre:

Handbooks and manuals.

Physical Description:

xi, 124 pages : illustrations, map ; 27 cm

Place of Publication:

Columbus, Ohio : Battelle Press, [2002]

Contents:

1.1 Why Consider Bioavailability in Risk Assessments? 1

1.2 Definitions and Concepts 2

1.3 Environmental Factors Controlling the Bioavailability of Metals in Soils 5

1.4 How Bioavailability is Incorporated into Risk Assessments 9

1.5 Situations When Bioavailability Should Be Considered 10

1.6 Other Factors that Determine Whether a Bioavailability Study is Appropriate and Feasible 11

1.7 Selected Case Studies 13

2 Designing/Conducting a Bioavailability Study 17

2.1 Steps in Conducting a Bioavailability Study 18

2.2 Types of Test Methods for Assessing Bioavailability 18

2.2.1 In Vitro Methods 18

2.2.2 In Vivo Methods 22

2.3 Soil Collection and Characterization 26

2.4 Cost and Resources Required 27

3 Arsenic 33

3.1 Predominant Forms in Soil 33

3.2 Toxicity Assessment 34

3.3 Summary of Relative Bioavailability Data 34

3.4 In Vitro Study Design Recommendations 34

3.5 In Vivo Study Design Recommendations 35

4 Cadmium 41

4.1 Predominant Forms in Soil 41

4.2 Toxicity Assessment 41

4.3 Summary of Relative Bioavailability Data 42

4.4 In Vitro Study Design Recommendations 42

4.5 In Vivo Study Design Recommendations 42

5 Chromium 47

5.1 Predominant Forms in Soil 47

5.2 Toxicity Assessment 48

5.3 Summary of Relative Bioavailability Data 48

5.4 In Vitro Study Design Recommendations 48

5.5 In Vivo Study Design Recommendations 49

6 Lead 55

6.1 Predominant Forms in Soil 55

6.2 Toxicity Assessment 55

6.3 Summary of Relative Bioavailability Data 56

6.4 In Vitro Study Design Recommendations 57

6.5 In Vivo Study Design Recommendations 57

7 Mercury 63

7.1 Predominant Forms in Soil 63

7.2 Toxicity Assessment 64

7.3 Summary of Relative Bioavailability Data 64

7.4 In Vitro Study Design Recommendations 64

7.5 In Vivo Study Design Recommendations 65

8 Nickel 69

8.1 Predominant Forms in Soil 69

8.2 Toxicity Assessment 70

8.3 Summary of Relative Bioavailability Data 70

8.4 In Vitro Study Design Recommendations 70

8.5 In Vivo Study Design Recommendations 70.

Notes:

Includes bibliographical references and index.

ISBN:

157477123X

OCLC:

48620351