Asthma and COPD : basic mechanisms and clinical management / edited by Peter J. Barnes ... [and others].

Format:

Book

Contributor:

Barnes, Peter J., 1946-

Language:

English

Subjects (All):

Asthma.

Lungs--Diseases, Obstructive.

Lungs.

Lungs--Diseases, Obstructive--Treatment.

Lung Diseases, Obstructive.

Medical Subjects:

Asthma.

Lung Diseases, Obstructive.

Physical Description:

xix, 780 pages, 4 unnumbered pages of plates : illustrations (some color) ; 29 cm

Place of Publication:

Amsterdam ; Boston : Academic Press, [2002]

Summary:

Chronic obstructive pulmonary disease (COPD), which encompasses both chronic bronchitis and emphysema, is one of the most common respiratory conditions of adults in the developed world. Asthma and COPD Basic Mechanisms and Clinical Management provides a unique, authoritative comparison of asthma and COPD. Written and edited by the world's leading experts, it is a comprehensive review of the most recent understanding of the basic mechanisms of both conditions, specifically comparing their etiology, pathogenesis, and treatments. * Highlights distinguishing features between asthma and COPD * Reviews benefits and limitations of current therapies * Summarises key information in two-colour artwork * Extensively referenced to primary literature

Contents:

Part I Definitions, Epidemiology, and Genetics of Asthma and COPD

2 Epidemiology / D.L. DeMeo, S.T. Weiss 7

3 Natural History / F.D. Martinez 19

4 Genetics / J. Gerritsen, M. Fiejen, D.S. Postma 29

Part II Physiology and Pathology of Asthma and COPD

5 Pulmonary Physiology / N.B. Pride 43

6 Airway Pathology / J.C. Hogg 57

7 Airway Remodeling / R.A. O'Donnell, D.E. Davies, S.T. Holgate 67

8 Animal Models / S.A. Shore 79

Part III Inflammatory Cells and Extracellular Matrix

9 Mast Cells and Basophils / G.H. Caughey 91

10 Macrophages / G.B. Toews 99

11 Eosinophils / W.B. Davis 111

12 Lymphocytes / C. Agostini, M. Saetta, G. Semenzato 119

13 Neutrophils / E.M. Drost, W. MacNee 131

14 Fibroblasts / R.J. McAnulty, G.J. Laurent 139

15 Epithelial Cells / J.R. Spurzem, S.I. Rennard 145

16 Mucus and Mucin-Secreting Cells / P-R. Burgel, J.A. Nadel 155

17 Airway Smooth Muscle / Y. Amrani, V.P. Krymskaya, A.L. Lazaar, R.A. Panettieri 165

18 Tracheobronchial Circulation / G. Horvath, A. Wanner 177

19 Pulmonary Vessels / N.F. Voelkel, R.M. Tuder 183

20 Plasma Exudation / C.G.A. Persson, J.S. Erjefalt, L. Uller, M. Andersson, L. Grieff 195

21 Cell Adhesion Molecules / A.L. Lazaar, S.M. Albelda 203

22 Extracellular Matrix / M. Godfrey 211

Part IV Inflammatory Mediators and Pathways

23 Prostanoids / P.M. O'Byrne 221

24 Leukotrienes / J.M. Drazen 227

25 Kinins / D. Proud 237

26 Reactive Oxygen Species / I. Rhaman, W. MacNee 243

27 Chemokines / J.E. Pease, T.J. Williams 255

28 Cytokines / K.F. Chung 261

29 Matrix Degrading Proteinases / S.D. Shapiro, E.J. Campbell 273

30 Growth Factors / M. Kolb, Z. Xing, J. Gauldie 283

31 Other Mediators of Airway Disease / P.J. Barnes 291

32 Nitric Oxide / A. Deykin, S.A. Kharatinov 307

33 Transcription Factors / I.M. Adcock, G. Caramori 315

34 Neural and Humoral Control / P.J. Barnes, N.C. Thomson 323

Part V Pathogenic Mechanisms in Asthma and COPD

35 Pathophysiology of Asthma / P.J. Barnes, J.M. Drazen 343

36 Pathogenesis of COPD / S. Rennard, P.J. Barnes 361

Part VI Triggers of Asthma and COPD

37 Allergens / D.W. Cockcroft 383

38 Occupational Agents / J.L. Malo, M. Chan-Yeung, S. Kennedy 395

39 Infections / S. Message, S. Johnston 407

40 Exercise as a Trigger / S. Godfrey 421

41 Atmospheric Pollutants / J. Ayres 431

42 Drugs / J. Gibson 439

Part VII Clinical Assessment of Asthma and COPD

43 Diagnosis / M. Romagnoli, L. Richeldi, L.M. Fabbri 447

44 Non-invasive Assessment of Airway Inflammation / S. Kharitonov 457

45 Imaging / S. Desai, D. Hansel 465

46 Assessment of Disability / P.W. Jones 481

Part VIII Therapies for Asthma and COPD

47 Allergen Avoidance / A. Custovic, A. Woodcock 489

48 Smoking Cessation / A.W.P. Molyneux, J. Britton 509

49 [beta subscript 2]-adrenoceptor Agonists / I.P. Hall 521

50 Anticholinergic Bronchodilators / S.E. Cattapan, N.J. Gross 527

51 Theophylline / P.J. Barnes 535

52 Corticosteroids / P.J. Barnes 547

53 Mediator Antagonists / K.F. Chung, P.J. Barnes 565

54 Antibiotics / S. Sharma, N. Anthonisen 573

55 Long-term Oxygen Therapy / B.R. Celli 587

56 Immunomodulators / C.J. Corrigan 599

57 Pulmonary Vasodilators / R.N. Channick, L.J. Rubin 605

58 Ventilator Support / S. Krachman, M. Tobin 611

59 Pulmonary Rehabilitation / E.F.M. Wouters 617

60 Surgery / J. Pepper 627

61 Other Therapies / N.C. Thomson 633

62 Future Therapies / P.J. Barnes 641

63 Health Economics / S.D. Sullivan, S.A. Strassels 657

Part IX Clinical Management of Asthma and COPD

64 Management of Chronic Asthma in Adults / A.J. Woolcock 675

65 Acute Exacerbations of Asthma / C. Kotaru, E.R. McFadden 689

66 Childhood Asthma / S. Godfrey 699

67 Treatment for Stable COPD / S.I. Rennard 713

68 Acute Exacerbations of COPD / J.A. Wedzicha 727

69 Education and Self-Management / M.R. Partridge 737.

Notes:

Includes bibliographical references and index.

ISBN:

0120790289

OCLC:

49238317