Fragile X syndrome : diagnosis, treatment, and research / edited by Randi Jenssen Hagerman and Paul J. Hagerman.

Format:

Book

Contributor:

Hagerman, Randi Jenssen, 1949-

Hagerman, Paul J.

Language:

English

Subjects (All):

Fragile X syndrome.

Fragile X Syndrome.

Medical Subjects:

Fragile X Syndrome.

Physical Description:

xii, 540 pages : illustrations ; 24 cm

Edition:

Third edition.

Place of Publication:

Baltimore : Johns Hopkins University Press, 2002.

Summary:

Fragile X syndrome is the most common inherited form of mental retardation. Now substantially revised and updated, this acclaimed book discusses the clinical approach to diagnosing the disorder, supported by the latest research in epidemiology, molecular biology and genetics, and neuropsychology. It also presents information on treatment: genetic counseling, pharmacotherapy, intervention, and gene therapy.

Contents:

I. Diagnosis and Research

1. The Physical and Behavioral Phenotype / Randi Jenssen Hagerman 3

2. The Molecular Biology of the Fragile X Mutation / W. Ted Brown 110

3. Epidemiology / Stephanie Sherman 136

4. FMR1 Protein Studies and Animal Model for Fragile X Syndrome / Ben A. Oostra, Andre T. Hoogeveen 169

5. Brain Structure and the Functions of FMR1 Protein / Scott Irwin, Roberto Galvez, Ivan Jeanne Weiler, Andrea Beckel-Mitchener, William Greenough 191

6. Neuropsychology / Loisa Bennetto, Bruce F. Pennington 206

II. Treatment and Intervention

7. Genetic Counseling / Louise W. Gane, Amy Cronister 251

8. Medical Follow-up and Pharmacotherapy / Randi Jenssen Hagerman 287

9. The Treatment of Emotional and Behavioral Problems / Jennifer L. Hills Epstein, Karen Riley, William E. Sobesky 339

10. An Integrated Approach to Intervention / Sarah Scharfenaker, Rebecca O'Connor, Tracy Stackhouse, Marcia L. Braden, Kristen Gray 363

11. Academic Interventions / Marcia L. Braden 428

12. FMR1 Gene Expression and Prospects for Gene Therapy / Paul J. Hagerman 465

Appendix 1. General Information about Fragile X Syndrome / Susan Harris 495

Appendix 2. Computer Software Information / Andrew Halpern, Lisa Nobel, Kristen Gray 501

Appendix 3. Learning Materials and Equipment / Andrew Halpern, Sarah Scharfenaker, Rebecca O'Connor, Tracy Stackhouse, Marcia L. Braden, Kristen Gray 514

Appendix 4. Toilet Training the Child with Fragile X Syndrome / Franci Crepeau-Hobson, Rebecca O'Connor 527.

Notes:

Includes bibliographical references and index.

ISBN:

0801868432

0801868440

OCLC:

48083782