Biostatistical genetics and genetic epidemiology / editors, Robert C. Elston, Jane M. Olson, Lyle Palmer.

Format:

Book

Contributor:

Elston, Robert C., 1932-

Olson, Jane M.

Palmer, Lyle.

Series:

Wiley reference series in biostatistics

Language:

English

Subjects (All):

Genetics--Statistical methods--Encyclopedias.

Genetics.

Genetic epidemiology--Statistical methods--Encyclopedias.

Genetic epidemiology.

Genetics, Medical.

Epidemiology.

Statistics.

Genetics--Statistical methods.

Medical Subjects:

Genetics, Medical.

Epidemiology.

Genre:

Encyclopedias.

Physical Description:

xxiv, 831 pages : illustrations ; 26 cm.

Place of Publication:

Chichester, West Sussex, England ; New York, NY : Wiley, [2002]

Summary:

Human Genetics concerns the study of genetic forces in man. By studying our genetic make-up we are able to understand more about our heritage and evolution. Some of the original, and most significant research in genetics centred around the study of the genetics of complex diseases - genetic epidemiology. This is the third in a highly successful series of books based on articles from the Encyclopedia of Biostatistics. This volume will be a timely and comprehensive reference, for a subject that has seen a recent explosion of interest following the completion of the first draft of the Human Genome Mapping Project. The editors have updated the articles from the Human Genetics section of the EoB, have adpated other articles to give them a genetic feel, and have included a number of newly commissioned articles to ensure the work is comprehensive and provides a self-contained reference.

Contents:

Admixture in Human Populations 1

Admixture Mapping 5

Adoption Studies 6

Age-of-Onset Estimation 10

Akaike's Criteria 17

Alternative Hypothesis 18

Anticipation 19

Ascertainment 20

Association 28

Association, Measures of 29

Assortative Mating 34

Attributable Risk 36

Bayes' Theorem 51

Bias 52

Bias in Case-Control Studies 52

Bioinformatics 61

Blood Groups 69

Bonferroni Inequalities and Intervals 70

Bootstrap Method 75

Candidate Gene 83

Carcinogenesis Models 83

Case-Cohort 89

Case-Control Study 95

Case-Only Gene Mapping 109

Causation 111

Cladistic Analysis 114

Cohort Studies 120

Collinearity 134

Commingling Analysis 136

Comparative Genomic Hybridization 139

Complex Diseases 141

Confidence Intervals and Sets 143

Confounder 144

Confounding 145

Consistent Estimator 152

Controls 158

Correlated Binary Data 159

Correlation 171

Covariate 176

Cox Regression Model 176

Cumulative Incidence 189

Diagnostics 191

Discriminant Analysis, Linear 196

Disease-Marker Association 206

DNA Sequences 217

Dummy Variables 227

Elston-Stewart Algorithm 231

EM Algorithm 232

Eugenics 246

Exclusion Mapping 251

Expectation 253

Experiment-Wise Error Rate 253

Familial Correlations 255

Family History Validation 261

Family-Based Association for Quantitative Traits 264

Family-Based Case-Control Studies 267

Fixed Effects 275

Founder Effect 275

Frailty 277

Frequency Matching 284

Gene 285

Gene Conversion 285

Gene Expression Analysis 286

Gene Frequency Estimation 293

Gene-Environment Interaction 297

General Linear Model 299

Generalized Estimating Equations 299

Generalized Linear Model 311

Generalized Maximum Likelihood 324

Genetic Correlations and Covariances 327

Genetic Counseling 331

Genetic Distance 334

Genetic Epidemiology 336

Genetic Heterogeneity 340

Genome-Wide Significance 344

Genotype 347

Genotyping and Error-Checking 348

Goodness of Fit 352

Haplotype Analysis 361

Hardy-Weinberg Equilibrium 369

Heritability 371

Heterozygosity 372

Hidden Markov Models 374

Hierarchical Models 382

HLA System 385

Human Genetics, Overview 386

Human Genome Project 390

Identity Coefficients 395

Importance Sampling 398

Inbreeding 402

Incidence Rate 406

Incidence-Prevalence Relationships 406

Incident Case 409

Information 409

Information Matrix 411

Interaction 412

Isolated Populations 414

Kin-Cohort Studies 419

Kurtosis 424

Lambda Criterion, Wilks' 427

Level of a Test 429

Liability Model 430

Likelihood 435

Likelihood Ratio 440

Likelihood Ratio Tests 441

Linear Regression, Simple 444

Linkage Analysis, Model-Based 448

Linkage Analysis, Model-Free 460

Linkage Disequilibrium 472

Linkage Information Content 475

Logistic Regression, Conditional 479

Loss of Heterozygosity 486

Map Functions 491

Marginal Likelihood 495

Marginal Models 496

Markers 501

Markov Chain Monte Carlo 502

Markov Chains 509

Matched Analysis 515

Matching 518

Maximum Likelihood 523

McNemar Test 526

Mendel's Laws 527

Meta-Analysis in Human Genetics 529

Mixed Model in Segregation Analysis 537

Molecular Epidemiology 540

Monte Carlo Methods 547

Multilocus (Gene x Gene) Interaction 550

Multiple Comparisons 552

Multiplicative Model 559

Multipoint Linkage Analysis 560

Multivariate Linkage Analysis 564

Multivariate Normal Distribution 568

Multivariate Normality, Tests of 573

Mutation 577

Neural Networks 579

Null Hypothesis 583

Odds Ratio 585

Ornstein-Uhlenbeck Process 585

Overmatching 588

P Value 591

Parental Effects 595

Parsimony 600

Partial Likelihood 600

Paternity Testing 602

Path Analysis 606

Pedigrees, Sequential Sampling 619

Penetrance 621

Pharmacogenetics 622

Polygenic Inheritance 626

Polymorphism 632

Polymorphism Information Content 632

Population Genetics 633

Population-Based Study 640

Power Transformations 640

Prediction 642

Prevalence 643

Principal Component Analysis 643

Profile Likelihood 652

Protecting Privacy in Genetic Studies 655

Pseudo-Likelihood 657

Radiation Hybrid Mapping 661

Random Effects 665

Regression 666

Regressive Models 666

Relationship Testing 673

Relative Odds 678

Relative Risk 678

Residuals 679

Response Variable 687

Risk Ratios 687

Segregation Analysis, Classical 693

Segregation Analysis, Complex 696

Segregation Ratios 708

Selection Bias 709

Sensitivity 709

Sequence Analysis 710

Sequential Linkage Analysis 712

Sex Ratio at Birth 716

Simulated Annealing 719

Simulation 720

Skewness 725

Software for Genetic Epidemiology 726

Specificity 736

Statistical Forensics 737

Stratification 740

Transformations 741

Transition Probabilities 742

Twin Analysis 743

Twin Concordance 756

Twin Registers 759

Two-Phase Sampling 761

Unbiasedness 767

Univariate Response 769

Validity and Generalizability in Epidemiologic Studies 771

Variance 777

Variance Component Analysis 778

X-linkage 791

Zygosity Determination 797.

Notes:

Includes bibliographical references and indexes.

ISBN:

0471486310

OCLC:

48531492