Hepatitis C virus : from laboratory to clinic / Mark A. Feitelson.

Format:

Book

Author/Creator:

Feitelson, Mark.

Language:

English

Subjects (All):

Hepatitis C.

Hepatitis C virus.

Hepacivirus.

Medical Subjects:

Hepatitis C.

Hepacivirus.

Physical Description:

xiv, 256 pages : illustrations ; 25 cm

Place of Publication:

Cambridge, U.K. ; New York : Cambridge University Press, 2002.

Summary:

An integrated, multidisciplinary account of the virus, its biology and clinical manifestations.

Contents:

2 The virus 19

3 Epidemiology and transmission 41

4 Natural history of infection 55

5 Pathogenesis of infection 65

6 Hepatitis C and hepatocellular carcinoma 85

7 Hepatitis C and autoimmune diseases 93

8 Clinical aspects of the disease 97

9 Current therapeutic approaches 101

10 Nonstructural protein 5A and interferon resistance 107

Part II Recent advances 111

11 Cell types supporting hepatitis C replication in vivo and in vitro 113

12 Understanding the natural history of hepatitis C 117

13 Animal models 119

14 Vaccine research 123

Part III Experimental approaches 127

15 New systems to understand hepatitis C biology 129

16 New antiviral screening assays 131

17 Antiviral gene therapy 135

Part IV Protocols and techniques 141

18 Sample collection, preparation, and storage 143

19 Hepatitis C RNA in blood and tissue samples 145

20 Hepatitis C genotyes and quasispecies 149

21 Replication of hepatitis C in tissue culture 151

22 Enzyme activities of nonstructural protein 3 153

23 Characterization of nonstructural protein 5B 157

Part V Some outstanding questions and emerging areas for investigation 159

24 Outstanding issues 161

25 Prospects 175.

Notes:

Includes bibliographical references (pages 177-247) and index.

ISBN:

0521799597

OCLC:

46928909