Cerebral blood flow and metabolism / editors, Lars Edvinsson, Diana N. Krause.

Format:

Book

Author/Creator:

Edvinsson, Lars.

Contributor:

Krause, Diana N.

Language:

English

Subjects (All):

Cerebral circulation.

Cerebrovascular disease--Pathophysiology.

Cerebrovascular disease.

Brain--Metabolism.

Brain.

Cerebrovascular Circulation--physiology.

Blood Flow Velocity--physiology.

Cerebrovascular Disorders--physiopathology.

Medical Subjects:

Cerebrovascular Circulation--physiology.

Blood Flow Velocity--physiology.

Cerebrovascular Disorders--physiopathology.

Physical Description:

xvii, 521 pages, 8 unnumbered pages of plates : illustrations (some color) ; 29 cm

Edition:

Second edition.

Place of Publication:

Philadelphia : Lippincott Williams & Wilkins, [2002]

Summary:

Written and edited by the world's foremost authorities, the Second Edition of this landmark work is a current, comprehensive reference on cerebral blood flow and metabolism. The book covers the entire field in a systematic and coherent way and synthesizes the diverse body of basic science and clinical literature. The reader will gain a complete understanding of the anatomical, physiological, and pharmacological bases of the cerebral circulation, its regulation in health and disease, and the pathophysiological disturbances occurring in cerebrovascular disorders. Coverage includes stimulating discussions of future directions for research and therapeutic intervention.

Contents:

I. The Anatomical Bases

1. General and Comparative Anatomy of the Cerebral Circulation / Lars Edvinsson, Eric T. MacKenzie 3

2. The Blood Vessel Wall: Endothelial and Smooth Muscle Cells / Lars Edvinsson, Diana N. Krause 30

3. Perivascular Nerves in Brain Vessels / Lars Edvinsson, Edith Hamel 43

II. The Physiologic Bases

4. Ion Channels in Cerebral Arteries / George C. Wellman, Mark T. Nelson 71

5. Pharmacomechanical Coupling in Cerebrovascular Smooth Muscle / William J. Pearce 88

6. Endothelial Regulation / Diana N. Krause 107

7. The Blood-Brain Barrier: Permeability, Substrate Transport, and Drug and Gene Targeting / William M. Pardridge 119

8. Energy Generation in the Central Nervous System / Gerald A. Dienel 140

9. Neurotransmitters: Metabolic and Vascular Effects / Pierre J. Magistretti, Luc Pellerin, Gilles Bonvento 162

10. Neurovascular Control of the Cerebral Circulation / Peter J. Goadsby, Lars Edvinsson 172

III. The Pharmacologic Bases

11. Catecholamines / Lars Edvinsson, Diana N. Krause 191

12. Neuropeptide Y / Lars Edvinsson, Diana N. Krause 212

13. Acetylcholine / Edith Hamel, Pierre Lacombe 222

14. Calcitonin Gene Related Peptide / Stefanie A. Kane, Kenneth S. Koblan 248

15. Neuropeptides / Lars Edvinsson, Diana N. Krause 256

16. 5-Hydroxytryptamine and Its Receptors / Richard Hargreaves, Margaret Beer 283

17. Nitric Oxide / Costantino Iadecola, Kiyoshi Niwa 295

18. Purines, Purine Nucleotides, and Pyrimidine Nucleotides / Robert M. Bryan, Jr. 311

19. Prostaglandins and Other Eicosanoids / David W. Busija 325

20. Endothelin / Jacob A. S. Hansen-Schwartz, Lars Edvinsson 339

21. Histamine / Lars Edvinsson, Anders Ottosson 354

22. Cytokines / William J. Pearce 362

IV. Fundamental Responses of the Cerebral Circulation

23. Measuring Cerebral Blood Flow and Metabolism / Ulrich Dirnagl, Lars Edvinsson, Arno Villringer 371

24. Changes in Arterial Gas Tension / Patricia D. Hurn, Richard J. Traystman 384

25. Autoregulation: Arterial and Intracranial Pressure / Jean-Marc Chillon, Gary L. Baumbach 395

26. Functional Brain Imaging / Marcus E. Raichle, Lars Edvinsson 413

V. Disordered Control: Pathophysiologic Aspects

27. Molecular Mechanisms of Ischemic Brain Damage / Tadeusz Wieloch 423

28. Neuroprotection in Stroke Therapy / Kennedy R. Lees, Hans-Christoph Diener 452

29. Primary Neurovascular Headache: Migraine and Cluster Headache from a Physiologic Perspective / Peter J. Goadsby, Arne May, Lars Edvinsson 457

30. Subarachnoid Hemorrhage: Extravasation of Blood in the Subarachnoid Space / Jacob A. S. Hansen-Schwartz, Lars Edvinsson 466

31. Aging and Dementia / Reinhard Grzanna 480.

Notes:

Includes bibliographical references and index.

ISBN:

0781722594

OCLC:

48093016