PARP as a therapeutic target / edited by Jie Zhang.

Format:

Book

Contributor:

Zhang, Jie.

Series:

Pharmacology & toxicology (Boca Raton, Fla.)

Pharmacology and toxicology

Language:

English

Subjects (All):

NAD-ADP-ribosyltransferase--Inhibitors--Therapeutic use--Testing.

NAD-ADP-ribosyltransferase.

ADP Ribose Transferases--antagonists & inhibitors.

ADP Ribose Transferases--therapeutic use.

Testing.

Medical Subjects:

ADP Ribose Transferases--antagonists & inhibitors.

ADP Ribose Transferases--therapeutic use.

Physical Description:

338 pages : illustrations ; 25 cm.

Place of Publication:

Boca Raton, FL : CRC Press, 2002.

Contents:

Chapter 1 Nervous System Functions of Poly(ADP-Ribose) Polymerase-1 / Krishna Juluri, Hyo Chol Ha, Solomon H. Snyder 1

Chapter 2 Role of Poly(ADP-Ribose) Polymerase-1 in Neurologic Disorders / Marc F. Poitras, Valina L. Dawson, Ted M. Dawson 19

Chapter 3 Involvement of PARP-1 and Poly(ADP-Ribosyl)ation in the Maintenance of Genomic Stability / Cynthia M. Simbulan-Rosenthal, Dean S. Rosenthal, Bassem H. Haddad, Danith Ly, Jie Zhang, Mark E. Smulson 39

Chapter 4 Functional Testing of Human PARP in Proliferation, Endotoxic Shock, and Radiosensitivity: A Genetic Rescue Study / Zdenko Herceg, Virginie Petrilli, Anton Wutz, Bernhard Auer, Marie-Pierre Cros, Zhao-Qi Wang 67

Chapter 5 PARP Inhibitors as Neuroprotective Agents for Brain Injury / Joel H. Greenberg, Michelle C. LaPlaca, Tracy K. McIntosh 83

Chapter 6 PARP Inhibitors and Cardioprotection / Christoph Thiemermann, Nicole Wayman, Michelle C. McDonald, Prabal Kumar Chatterjee 117

Chapter 7 Neuroprotection of the Retina with 3-Aminobenzamide, a PARP Inhibitor / Tim T. Lam 135

Chapter 8 Poly(ADP-Ribose) Polymerase Inhibitors and Acute Renal Failure / Prabal Kumar Chatterjee, Christoph Thiemermann 149

Chapter 9 Role of Poly(ADP-Ribose) Polymerase Activation in the Pathogenesis of Shock and Inflammation / Csaba Szabo 169

Chapter 10 Clinical Development of the Nicotinamides and Benzamides Involving PARP as a Molecular Target / Ronald W. Pero, Anders Olsson, Hanna Lindgren, Tomas Leanderson 205

Chapter 11 Chemoprotective Effect of a Novel PARP Inhibitor / Gyorgy Rabloczky, Laszlo Jaszlits, Gyorgy Bardos, Balazs Sumegi, Kalman Tory, Ildiko Racz, Beatrix Farkas, Attila Sandor, Zoltan Berente, Erzsebet Osz, Judit Szilvassy, Istvan Sziklai, Sandor Bernath, Peter Literati Nagy 223

Chapter 12 Beneficial Effect of GPI 6150 Treatment in Multiple Animal Models of Diseases / Jie Zhang 239

Chapter 13 Protecting Effect of PARP Inhibition on Ultraviolet Light-Induced Skin Damage / Beatrix Farkas, Balazs Sumegi, Gyorgy Rabloczky, Bela Csete, Balazs Hodosi, Marta Magyarlaki, Sandor Bernath, Peter Literati Nagy 257

Chapter 14 Role of Poly(ADP-Ribose) Polymerase Activation in the Pathogenesis of Diabetes Mellitus and Diabetic Vascular Dysfunction / Jon G. Mabley, Laszlo Virag, Csaba Szabo 277

Chapter 15 Therapeutic Targeting of the PARPs: Future Challenges, Future Opportunities / Myron K. Jacobson, Elaine L. Jacobson 321.

Notes:

Includes bibliographical references and index.

ISBN:

0849300738

OCLC:

48055520