Folate and human development / edited by Edward J. Massaro and John M. Rogers.

Format:

Book

Contributor:

Massaro, Edward J.

Rogers, John M.

Language:

English

Subjects (All):

Neural tube--Abnormalities--Etiology.

Neural tube.

Folic acid deficiency.

Folic acid in human nutrition.

Folic Acid--metabolism.

Folic Acid Deficiency.

Homocystine.

Neural Tube Defects--etiology.

Medical Subjects:

Folic Acid--metabolism.

Folic Acid Deficiency.

Homocystine.

Neural Tube Defects--etiology.

Physical Description:

xii, 359 pages : illustrations ; 24 cm

Place of Publication:

Totowa, N.J. : Humana Press, [2002]

Summary:

An authoritative panel of basic and clinical researchers critically reviews the latest findings on the role of folate in human development, health, and disease. Specific areas addressed include folate metabolism in zinc or copper deficiencies, choline and folate in development, animal models of folate-related birth defects, developmental toxicants potentially acting via folate perturbation, and folate's role in vascular disease in women. There are also cutting-edge discussions of genes and neural tube development, folate receptor polymorphism and the risk for neural defects, abnormal DNA synthesis and methylation with folate/methyl insufficiency, and folic acid and homocysteine as risk factors for neural tube defects.

Contents:

1 Animal Models of Folate-Related Neural Tube Defects / Nicholas D. E. Greene, Andrew J. Copp 1

2 Genetic Variation in Folate Metabolism: Impact on Development / Rima Rozen 27

3 Folate Deficiency and the Molecular Determinants of Chromosome Instability: Possible Link to Meiotic Nondisjunction and Down Syndrome / S. Jill James, Charlotte A. Hobbs 43

4 Folic Acid, Vitamin B[subscript 12], and Genomic Stability of Human Cells / Michael Fenech 71

5 Molecular Genetics of Folate Metabolism / Manuela Fodinger, Sonja Skoupy, Gere Sunder-Plassmann 91

6 Folate Receptor-[alpha]: An Update / Barton A. Kamen 117

7 Folate, Homocysteine, and Neural Tube Defects / Tom K. A. B. Eskes 137

8 Folic Acid and Homocysteine as Risk Factors for Neural Tube Defects / Robert C. Barber, Janee van Waes, Edward J. Lammer, Gary M. Shaw, Thomas H. Rosenquist, Richard H. Finnell 165

9 Developmental Toxicants Potentially Acting via Folate Perturbation / Deborah K. Hansen 183

10 Brain Development and Choline, the Other Methyl Donor ... / Steven H. Zeisel 205

11 Nutrient Interactions Between Folate and Zinc or Copper: Their Possible Implications to Pregnancy Outcome / Tsunenobu Tamura 219

12 Regulation of Folate Metabolism by Iron / A. Katherine Herbig, Patrick J. Stover 241

13 A Differential Role for Folate in Developmental Disorders, Vascular Disease, and Other Clinical Conditions: The Importance of Folate Status and Genotype / Mark Lucock, Zoe Yates 263

14 Vascular Disease in Women: Folate and Homocysteine / Tom K. A. B. Eskes 299

15 Folate, Homocysteine, and Cardiovascular Disease / Jayne V. Woodside, Ian S. Young 329.

Notes:

Includes bibliographical references and index.

ISBN:

0896039366

OCLC:

48435441