Optimization of solid-phase combinatorial synthesis / edited by Bing Yan, Anthony W. Czarnik.

Format:

Book

Contributor:

Yan, Bing.

Czarnik, Anthony W., 1957-

Language:

English

Subjects (All):

Solid-phase synthesis.

Combinatorial chemistry.

Physical Description:

xi, 385 pages : illustrations ; 24 cm

Place of Publication:

New York : Marcel Dekker, [2002]

Contents:

1. A System for the Development and Production of Small-Molecule Libraries / Armen M. Boldi, Charles R. Johnson 1

2. Quality Control of Combinatorial Libraries Encoded with Electrophoric Tags: A Case Study / Roland E. Dolle 29

3. How to Optimize Reactions for Solid-Phase Synthesis of Combinatorial Libraries Using RF-Tagged Microreactors / Rongshi Li 55

4. Key Factors in the Translation of Solution-Phase Chemistry to the Solid Phase / Pedro H. H. Hermkens, Hans Hamersma, Adrianus P. A. de Man 69

5. The Choice of Solid Support / Wim Van Den Nest, Fernando Albericio 91

6. Applications of Fluorine-19 NMR Spectroscopy to Combinatorial Chemistry / Jill Hochlowski 109

7. Optimization of Solid-Phase Organic Syntheses by Monitoring Reactions on Single Resin Beads Using FTIR Microspectroscopy / Bing Yan, Robert F. Dunn, Qing Tang, Gary M. Coppola, Isidoros Vlattas 129

8. Spectroscopic Techniques for Optimizing Combinatorial Reactions on Solid Supports / Andrea M. Sefler, Douglas J. Minick 165

9. Analytical Methods in Library Feasibility and Rehearsal Studies / Bing Yan, Tushar Kshiragar, Liling Fang, Pascal Fantauzzi, Jianmin Pan 197

10. Approaches to Reaction Monitoring by Product Derivatization / Miles S. Congreve, Corinne Kay, Jan Scicinski 215

11. Methods for Quantitative Analysis of Compound Cleavage from Solid-Phase Resins / Nikhil Shah, George Detre, Stephen Raillard, William L. Fitch 251

12. Hammett Relationships and Solid-Phase Synthesis: The Application of a Classical Solution to a Modern Problem / Samuel W. Gerritz 263

13. Multispectral Imaging for the High Throughput Evaluation of Solid-Phase-Supported Chemical Libraries / Hicham Fenniri, Ryan M. McFadden 287

14. Microwave Applications to the Optimization of Combinatorial Synthesis / Joy Jing-Yi Yang, Yen-Ho Chu, Shui-Tein Chen 305

15. Optimizing Solution-Phase Synthesis Using Solid-Phase Techniques / Michael G. Organ, Debasis Mallik 315.

Notes:

Includes bibliographical references and index.

ISBN:

0824706544

OCLC:

48649094