Mouse development : patterning, morphogenesis, and organogenesis / edited by Janet Rossant and Patrick P. L. Tam.

Format:

Book

Contributor:

Rossant, Janet.

Tam, Patrick P. L.

Rosengarten Family Fund.

Language:

English

Subjects (All):

Mice--Physiology.

Mice.

Mice as laboratory animals.

Mice--physiology.

Animals, Laboratory.

Medical Subjects:

Mice--physiology.

Animals, Laboratory.

Physical Description:

xviii, 712 pages : illustrations ; 29 cm

Place of Publication:

San Diego, Calif. ; London : Harcourt Academic, 2002.

Summary:

This book represents a classic compilation of current knowledge about mouse development and its correlates to research in cell biology, molecular biology, genetics, and neuroscience. Emphasis is placed on the research strategy, experimental design, and critical analysis of the data, disguishing this from other books that only focus on protocols for mouse developmental research. Selected chapters are indexed to electronic databases such as GeneBank, GenBank, Electronic Mouse Atlas, and Transgenic/Knockout, further increasing the utility of this book as a reference. *Broad-based overview of mouse development from fundamental to specialist levels*Extensive coverage of a wide range of developmental mutations of the mouse*Excellent benchmark illustrations of brain, craniofacial, gut and heart development*In-depth experiment-based assessment of concepts in mammalian development*Focus on models of specific relevance to human development*Comprehensive reference to key literature and electronic databases related to mouse development*High-quality full-color production

Contents:

I Establishment of Body Patterns

1 Fertilization and Activation of the Embryonic Genome / Davor Solter, Wilhelmine N. de Vries, Alexei V. Evsikov, Anne E. Peaston, Frieda H. Chen, Barbara B. Knowles

II. Oogenesis 6

III. Meiosis and the Beginning of Oocyte Asymmetry 7

IV. Fertilization 8

V. Transcription andlts Control 8

VI. mRNA Utilization during Oocyte Maturation and Preimplantation Development 10

VII. Gene Expression in the Early Mouse Embryo 11

VIII. Functional Analysis 13

2 Asymmetry and Prepattern in Mammalian Development / R. L. Gardner

II. Asymmetries in Early Development 23

III. Asymmetry of the Blastocyst 27

IV. Specification of the Polarity of the Anterior-Posterior Axis of the Fetus? 29

3 Anterior Posterior Patterning of the Mouse Body Axis at Gastrulation / Stew-Lan Ang, Richard R. Behringer

II. Gastrulation 38

III. The Node: Morphogenesis, Cell Fate, and Cell Movement 38

IV. The Organizer Phenomenon: Conserved Properties of Vertebrate Organizers 40

V. The Vertebrate Organizer is a Dynamic, Nonhomogeneous, and Renewable Cell Population at Gastrulation 40

VI. Insights into the Function of the Mouse Organizer Gained from Genetic and Embryological Studies 41

VII. Genetic Analysis of Organizer Function: Mouse Mutants Showing Defects in Organizer Function 42

VIII. Inhibitory Signals Secreted by the Organizer and Its Derivatives 44

IX. Specification of the Primitive Streak and the Organizer 44

X. Role of the AVE in Anterior Patterning in Mouse 45

XI. Embryological and Genetic Analysis of the Function of the AVE in Anterior Patterning 46

XII. A Model for AVE Function in Anterior Patterning 47

XIII. Conclusions and Future Directions 48

4 Left-Right Asymmetry / Hiroshi Hamada

II. Morphological Left-Right Asymmetries 56

III. Genetic/Molecular pathway Governing Left-Right Determination 58

IV. Molecular Readout of the First Asymmetry 61

V. Role of the Midline 64

VI. Readout of Left-Right Asymmetry in Later Development 65

VII. Miscellaneous Mutations/Gene Factors 67

VIII. Diversity among Vertebrates 68

IX. Future Challenges 69

5 Patterning, Regionalization, and Cell Differentiation in the Forebrain / Oscar Marin, John L. R. Rubenstein

I. Organization of the Forebrain 75

II. Early Patterning and Regional Specification of the Forebrain 78

III. Morphogenetic Mechanisms in the Forebrain 85

IV. Control of Neurogenesis and Cell-Type Specification in the Forebrain 87

6 Establishment of Anterior-Posterior and Dorsal-Ventral Pattern in the Early Central Nervous System / Alexandra L. Joyner

I. Overview of Early CNS Development and Patterning 107

II. Anterior-Posterior Patterning of the Mesencephalon and Metencephalon 110

III. Hindbrain Anterior-Posterior Patterning Involves Segmental Units of Development 117

IV. CNS Dorsal-Ventral Patterning Involves a Tug of War between Dorsal and Ventral Signaling 120

7 Somitogenesis: Segmentation of the Paraxial Mesoderm and the Delineation of Tissue Compartments / Achim Gossler, Patrick P. L. Tam

I. Overview of Somite Development 127

II. Allocation of Progenitor Cells to the Paraxial Mesoderm 132

III. Cells Are in Transit in the Presomitic Mesoderm 132

IV. Regionalized Genetic Activity Points to a Prepattern of Prospective Somites 133

V. Emergence of Anterior-Posterior Somite Compartments 134

VI. Role of Notch Signaling in the Establishment of Somite Borders and Anterior-Posterior Polarity 134

VII. A Molecular Clock Operates in the Paraxial Mesoderm to Control the Kinetics of Somite Formation 138

VIII. Specification of Lineage Compartments by Inductive Interactions 139

II Lineage Specification and Differentiation

8 Extraembryonic Lineages / Janet Rossant, James C. Cross

II. Early Development of the Trophoblast and Primitive Endoderm Lineages 156

III. Cell Lineage Analysis and the Extraembryonic Lineages 156

IV. Setting Aside the Blastocyst Lineages 158

V. Molecular Specification of the Blastocyst Cell Lineages 159

VI. Differentiation of the Yolk Sacs 161

VII. Morphogenetic Events in Development of the Chorioallantoic Placenta 161

VIII. Comparative Aspects of Development of Extraembryonic Membranes 162

IX. Molecular Control of Primitive Endoderm Development 164

X. Signaling Pathways in Early Trophoblast Development 166

XI. Control of Spongiotrophoblast and Giant Cell Fate 168

XII. Trophoblast Giant Cell Development: Gene Pathways and Control of Endoreduplication 169

XIII. Initiating Chorioallantroic Fusion 170

XIV. Gcm1 Regulates the Initiation of Chorioallantoic Branching 170

XV. Growth Factor Signaling Regulates Branching Morphogenesis of the Labyrinth 171

XVI. Placental Development and Pregnancy Complications 173

9 Germ Cells / Christopher Wylie, Robert Anderson

I. General Concepts 181

II. Early Appearance of Germ Cells in the Mouse 182

III. Specification of Germ Cells in the Mouse 183

IV. Migration of Germ Cells 185

V. Motility of Germ Cells 185

VI. Guidance of Germ Cell Migration 186

VII. Adhesive Behavior of Germ Cells during Migration 187

VIII. Survival and Proliferation of Germ Cells during Migration 188

10 Development of the Vertebrate Hematopoietic System / Nancy Speck, Marian Peeters, Elaine Dzierzak

II. Cellular Aspects of Blood Development in the Mouse Embryo 192

III. Molecular Genetic Aspects of Blood Development in the Mouse Embryo 202

IV. Current Cellular and Molecular Conceptual Frameworks for Hematopoietic Ontogeny 205

V. Future Directions 206

11 Vasculogenesis and Angiogenesis / Thomas N. Sato, Siobhan Loughna

II. Overview of Vascular Development 211

III. Generation of Endothelial Cells 212

IV. Vascular Morphogenesis 220

12 Stem Cells of the Nervous System / Sean J. Morrison

II. Lineage Determination of Neural Stem Cells 237

III. Do Stem Cells Retain Broad or Narrow Neuronal Potentials? 241

IV. Regulation of Neural Stem Cell Self-Renewal 242

V. Differences between Hematopoietic Stem Cells and Neural Stem Cells 243

VI. In Vivo Function of Neural Stem Cells 244

VII. Surprising Potential of Neural Stem Cells 245

VIII. Are Neural Stem Cells Involved in Disease? 246

IX. Outstanding Issues 248

13 Cellular and Molecular Mechanisms Regulating Skeletal Muscle Development / Atsushi Asakura, Michael A.Rudnicki

II. Embryonic Origin of Skeletal Muscle 254

III. MyoD Family of Myogenic Regulatory Factors 256

IV. Muscle-Specific Transcriptional Regulation 262

V. Inductive Mechanisms of Myogenesis 262

VI. Specification of Muscle Fiber Types 268

VII. Muscle Regeneration 269

14 Deconstructing the Molecular Biology of Cartilage and Bone Formation / Benoit de Crombrugghe, Veronique Lefebvre, Kazuhisa Nakashima

II. Sox Transcription Factors: Essential Roles in the Chondrocyte Differentiation Program 281

III. Parathyroid Hormone-Related Peptide (PTHrP) and Parathyroid Hormone (PTH)/PTHrP Receptor: Gatekeepers of the Zone of Hypertrophic Chondrocytes 284

IV. FGFs and FGF Receptor 3: Counterintuitive Inhibitors of Chondrocyte Proliferation 286

V. Ihh: A Central Coordinator of Endochondral Bone Formation 287

VI. The Two Roles of the Transcription Factor Cbfa 1 in Endochondral Bone Formation 288

VII. Other Transcription Factors Involved in Bone Formation 290

VIII. Gelatinase B and Vascular Endothelial Growth Factor: Additional Coordinators of Endochondral Bone Formation 290

III Organogenesis

15 Development of the Endoderm and Its Tissue Derivatives / Brigid L. M. Hogan, Kenneth S. Zaret

II. Endoderm Development prior to Organogenesis 302

III. Patterning and Differentiation of the Digestive Tract 307

IV. Development of Tissues That Bud from the Endoderm 310

V. Perspectives and Remaining Issues on Organogenesis from the Endoderm 322

16 Molecular Determinants of Cardiac Development and Congenital Disease / Richard P.

Harvey

II. Overview of Heart Structure and Development 332

III. A Conserved Pathway for Cardiac Induction and Morphogenesis 334

IV. Cardiac Induction: The Role of Endoderm 334

V. Bone Morphogenetic Proteins as Cardiac Inducing Molecules 336

VI. Other Factors Involved in Cardiac Induction 336

VII. A Role for Anterior Visceral Endoderm in Cardiac Induction in the Mouse? 338

VIII. The Heart Morphogenetic Field 339

IX. The Size and Shape of the Heart Field 339

X. The Timing and Stability of Cardiac Induction 340

XI. Migration of Cardiac Precursors 340

XII. Cellular Proliferation and Death in the Forming Heart 341

XIII. Cardiac Myogenesis 341

XIV. Modulation of Myogenesis in Heart Chambers 343

XV. Regionality in the Developing Heart 343

XVI. Plasticity of Heart Regionalization 344

XVII. The Segmental Model of Cardiac Morphogenesis 344

XVIII. An Inflow/Outflow Model of Early Heart Tube Patterning 345

XIX. A Role for Retinoic Acid Signaling in Inflow/Outflow Patterning 346

XX. A Role for the Delta/Notch Pathway in Primary Heart Patterning 347

XXI. Cardiac Chamber Formation 347

XXII. Ventricular Specification: Knock-Out and Transgenic Phenotypes 348

XXIII. Transcriptional Circuits Acting in Chamber Formation 351

XXIV. The Cardiac Left-Right Axis 351

XXV. Developmental Pathways and Congenital Heart Disease 356

XXVI. Horizons 357

17 Sex Determination and Differentiation / Amanda Swain, Robin Lovell-Badge

II. Gonad Development 372

III. Sex Determination 376

IV. Testis Differentiation 380

V. Cell Movement and Proliferation in the Early Gonad 382

VI. Ovary Differentiation 384

VII. Sexual Development 384

VIII. Evolution and Sex Determination 386

18 Development of the Excretory System / Gregory R. Dressler

II. Patterning of the Intermediate Mesoderm 396

III. Growth of the Nephric Duct and Ureteric Bud Diverticulum 400

IV. Inductive Interactions 404

V. Mesenchyme-to-Epithelial Conversion 407

VI. Glomerular Development and Vascularization 412

VII. Developmental Basis of Human Renal Disease 414

VIII. Future Perspectives 416

19 Craniofacial Development / Michael J. Depew, Abigail S. Tucker, Paul T. Sharpe

II. Primordial Cells of the Head 422

III. Organ Development 433

V. Appendix 1: Descriptive Dental Development 454

VI. Appendix 2: Morphological Organization of the Murine Skull 456

VII. Appendix 3: Molecular Regulators of Craniofacial Pattern and Development 465

20 Pituitary Gland Development / Sally Camper, Hoonkyo Suh, Lori Raetzman, Kristin Douglas, Lisa Cushman, Igor Nasonkin, Heather Burrows, Phil Gage, Donna Martin

I. Pituitary Gland Anatomy and Function 499

II. Development of the Pituitary Primordia and Cell Specification 500

III. Expansion of Committed Cell Types 510

21 Development of the Eye / Hisato Kondoh

I. Overview of Eye Development 519

II. Development of the Retina 521

III. Lens Development 528

IV. Conservation and Divergence of the Transcriptional Regulatory Systems in the Eye Development 533

22 Development of the Mouse Inner Ear / Amy E. Kiernan, Karen P. Steel, Donna M. Fekete

II. Anatomy of the Inner Ear 540

III. Development of the Inner Ear 541

IV. Early Development of the Otic Blacode and Otocyst 542

V. Pattern Formation in the Inner Ear 546

VI. Sensory Differentiation 552

VII. Neurogenesis 558

VIII. The Stria Vascularis 559

IX. Future Directions 560

23 Integumentary Structures / Carolyn Byrne, Matthew Hardman

II. Mature Skin 569

III. Non-Neural Embryonic Ectoderm 570

IV. Stratification 571

V. Dermal Development 572

VI. Epidermal Appendage Morphogenesis 574

VII. Model for Follicle Formation: The First Dermal Signal 574

VIII. Follicle Spacing 577

IX. Follicle Morphogenesis and Differentiation 578

X. Follicle Morphogenesis and Follicle Cycling 578

XI. Molecular Parallels between Skin Tumorigenesis and Skin Development 579

XII. Early Terminal Differentiation 579

XIII. Regulation of Transit to Late Stages of Terminal Differentiation 580

XIV. Late Terminal Differentiation: Formation of Stratum Corneum and Skin Barrier 581

XV. Periderm Disaggregation 583.

Notes:

Includes bibliographical references and index.

Local Notes:

Acquired for the Penn Libraries with assistance from the Rosengarten Family Fund.

ISBN:

0125979517

OCLC:

48752775