Biostatistical methods / edited by Steven W. Looney.

Format:

Book

Contributor:

Looney, Steven W.

Series:

Methods in molecular biology (Clifton, N.J.) ; v. 184.

Methods in molecular biology ; v. 184

Language:

English

Subjects (All):

Biometry.

Molecular biology.

Biometry--methods.

Molecular Biology--methods.

Medical Subjects:

Biometry--methods.

Molecular Biology--methods.

Physical Description:

xii, 214 pages : illustrations ; 24 cm.

Place of Publication:

Totowa, NJ : Humana Press, 2002.

Summary:

Leading biostatisticians and biomedical researchers describe many of the key techniques used to solve commonly occurring data analytic problems in molecular biology, and demonstrate how these methods can be used in the development of new markers for exposure to a risk factor or for disease outcomes. Major areas of application include microarray analysis, proteomic studies, image quantitation, genetic susceptibility and association, evaluation of new biomarkers, and power analysis and sample size.

Contents:

1 Statistical Contributions to Molecular Biology / Emmanuel N. Lazaridis, Gregory C. Bloom 1

2 Linking Image Quantitation and Data Analysis / Gregory C. Bloom, Peter Gieser, Emmanuel N. Lazaridis 15

3 Introduction to Microarray Experimentation and Analysis / Peter Gieser, Gregory C. Bloom, Emmanuel N. Lazaridis 29

4 Statistical Methods for Proteomics / Francoise Seillier-Moiseiwitsch, Donald C. Trost, Julian Moiseiwitsch 51

5 Statistical Methods for Assessing Biomarkers / Stephen W. Looney 81

6 Power and Sample Size Considerations in Molecular Biology / L. Jane Goldsmith 111

7 Models for Determining Genetic Susceptibility and Predicting Outcome / Peter W. Jones, Richard C. Strange, Sud Ramachandran, Anthony Fryer 131

8 Multiple Tests for Genetic Effects in Association Studies / Peter H. Westfall, Dmitri V. Zaykin, S. Stanley Young 143

9 Statistical Considerations in Assessing Molecular Markers for Cancer Prognosis and Treatment Efficacy / James Dignam, John Bryant, Soonmyung Paik 169

10 Power of the Rank Test for Multi-Strata Case-Control Studies with Ordinal Exposure Variables / Grzegorz A. Rempala, Stephen W. Looney 191.

Notes:

Includes bibliographical references and index.

ISBN:

089603951X

OCLC:

46959789