Tumor models in cancer research / edited by Beverly A. Teicher.

Format:

Book

Contributor:

Teicher, Beverly A., 1952-

Series:

Cancer drug discovery and development

Language:

English

Subjects (All):

Tumors--Animal models.

Tumors.

Cancer cells.

Oncology, Experimental.

Neoplasms, Experimental.

Disease Models, Animal.

Medical Subjects:

Neoplasms, Experimental.

Disease Models, Animal.

Physical Description:

xv, 690 pages : illustrations ; 26 cm.

Place of Publication:

Totowa, N.J. : Humana Press, [2002]

Summary:

Beverly A. Teicher and a panel of leading experts comprehensively describe for the first time in many years the state-of-the-art in animal tumor model research. The wide array of models detailed form the basis for the selection of compounds and treatments that go into clinical testing of patients, and include syngeneic models, human tumor xenograft models, orthotopic models, metastatic models, transgenic models, and gene knockout models. Synthesizing many years experience with all the major in vivo models currently available for the study of malignant disease, Tumor Models in Cancer Research provides preclinical and clinical cancer researchers alike with a comprehensive guide to the selection of these models, their effective use, and the optimal interpretation of their results.

Contents:

1 Perspective on the History of Tumor Models / Steadman Harrison 3

Part II Transplantable Syngeneic Rodent Tumors

2 Murine L1210 and P388 Leukemias / Donald J. Dykes, William R. Waud 23

3 Transplantable Syngeneic Rodent Tumors: Solid Tumors in Mice / Thomas H. Corbett, Lisa Polin, Bill J. Roberts, Alfred J. Lawson, Wilbur R. Leopold III, Kathryn White, Juiwanna Kushner, Jennifer Paluch, Stuart Hazeldine, Richard Moore, James Rake, Jerome P. Horwitz 41

4 B16 Murine Melanoma: Historical Perspective on the Development of a Solid Tumor Model / Enrique Alvarez 73

Part III Human Tumor Xenografts

5 Xenotransplantation of Human Cell Cultures in Nude Mice / Beppino Giovanella 93

6 GFP-Expressing Metastatic-Cancer Mouse Models / Robert M. Hoffman 99

7 Human Tumor Xenografts and Explants / Heinz-Herbert Fiebig, Angelika M. Burger 113

Part IV Carcinogen-Induced Tumors: Models of Carcinogenesis and Use for Therapy

8 Hamster Oral Cancer Model / Joel Schwartz, Xinbin Gu 141

9 Mammary Cancer in Rats / Henry J. Thompson, Michael B. Sporn 173

10 Carcinogen-Induced Colon-Cancer Models for Chemoprevention and Nutritional Studies / Bandaru S. Reddy 183

Part V Mutant, Transgenic, and Knockout Mouse Models

11 Cancer Models: Manipulating the Transforming Growth Factor-[beta] Pathway in Mice / John J. Letterio 195

12 Cyclin D1 Transgenic Mouse Models / Oliver G. Opitz, Hiroshi Nakagawa, Anil K. Rustgi 223

13 Mice Expressing the Human Carcinoembryonic Antigen: An Experimental Model of Immunotherapy Directed at a Self, Tumor Antigen / John W. Greiner 231

14 The p53-Deficient Mouse as a Cancer Model / Sundaresan Venkatachalam, Stuart Tyner, Lawrence A. Donehower 247

15 The Utility of Transgenic Mouse Models for Cancer Prevention Research / Stephen D. Hursting, Ronald A. Lubet 263

Part VI Metastasis Models

16 Metastasis Models: Lungs, Spleen/Liver, Bone, and Brain / Krishna Menon, Beverly A. Teicher 277

17 Models for Evaluation of Targeted Therapies of Metastatic Disease / Suzanne A. Eccles 293

Part VII Normal Tissue Response Models

18 Animal Models of Oral Mucositis Induced by Antineoplastic Drugs and Radiation / Stephen T. Sonis 323

19 The Intestine as a Model for Studying Stem-Cell Behavior / Catherine Booth, Christopher S. Potten 337

20 SENCAR Mouse-Skin Tumorigenesis Model / Rana P. Singh, Rajesh Agarwal 359

21 Murine Models of Bone-Marrow Transplant Conditioning / Ronald van Os, Julian D. Down 381

22 Anesthetic Considerations for the Study of Murine Tumor Models / Robert E. Meyer, Rod D. Braun, Mark W. Dewhirst 407

Part VIII Disease and Target-Specific Models

23 Tissue-Isolated Tumors in Mice: Ex Vivo Perfusion of Human Tumor Xenografts / Paul E. G. Kristjansen 435

24 Human Breast-Cancer Xenografts as Models of the Human Disease / Robert Clarke 453

25 Animal Models of Melanoma / William E. Carson III, Michael J. Walker 471

26 Experimental Animal Models for Renal Cell Carcinoma / Gilda G. Hillman 493

27 Animal Models of Mesothelioma / Harvey I. Pass, Orlin Hadjiev, Michele Carbone 507

28 SCID Mouse Models of Human Leukemia and Lymphoma as Tools for New Agent Development / Fatih M. Uckun, Martha G. Sensel 521

29 Models for Studying the Action of Topoisomerase-I Targeted Drugs / Joyce Thompson, Clinton F. Stewart, Peter J. Houghton 541

30 Spontaneous Pet Animal Cancers / Mark W. Dewhirst, Donald Thrall, E. Gregory MacEwen 565

Part IX Experimental Methods and End Points

31 In Vivo Tumor Response End Points / Beverly A. Teicher 593

32 Tumor-Cell Survival / Sara Rockwell 617

33 Apoptosis In Vivo / L. Clifton Stephens, Raymond E. Meyn 633

34 Transparent Window Models and Intravital Microscopy: Imaging Gene Expression, Physiological Function, and Drug Delivery in Tumors / Rakesh K. Jain, Lance L. Munn, Dai Fukumura 647.

Notes:

Includes bibliographical references and index.

ISBN:

0896038874

OCLC:

46359869