Nucleic acids : structures, properties, and functions / Victor A. Bloomfield, Donald M. Crothers, Ignacio Tinoco, Jr. ; with contributions from John E. Hearst ... [and others].

Format:

Book

Author/Creator:

Bloomfield, Victor A.

Contributor:

Crothers, Donald M.

Tinoco, Ignacio

Alumni and Friends Memorial Book Fund.

Language:

English

Subjects (All):

Nucleic acids.

Nucleic Acids.

DNA.

RNA.

Medical Subjects:

Nucleic Acids.

DNA.

RNA.

Physical Description:

x, 794 pages, 15 unnumbered pages of plates : illustrations (some color) ; 26 cm

Place of Publication:

Sausalito, Calif. : University Science Books, [2000]

Summary:

Provides a detailed account of the structures and physical chemistry properties of nucleic acids, with an emphasis on the implications for biological function. The volume is organized to be of use to physical chemists, physical biochemists, and molecular biologists as well as students in those disciplines, requiring only a basic understanding of physical chemistry and molecular biology as prerequisites. Each chapter begins with a statement of the biological significance of each topic, followed by a presentation of the basic physical ideas and major results. Quantitative details are developed in special sections or appendices.

Contents:

Introduction

Bases, nucleosides, and nucleotides

Chemical and enzymatic methods

Nucleic acid structures from diffraction methods

Structure and dynamics by NMR

Electronic and vibrational spectroscopy

Theoretical methods

Conformational changes

Size and shape of nucleic acids in solution

Supercoiled DNA

Interaction of nucleic acids and water and ions

Interaction and reaction with drugs

Protein-nucleic acid interactions

Higher order structure.

Notes:

Includes bibliographical references and index.

Local Notes:

Acquired for the Penn Libraries with assistance from the Alumni and Friends Memorial Book Fund.

ISBN:

0935702490

OCLC:

39936769