Principles of clinical pharmacology / [edited by] Arthur J. Atkinson, Jr. ... [and others].

Format:

Book

Contributor:

Atkinson, Arthur J., Jr.

Alumni and Friends Memorial Book Fund.

Language:

English

Subjects (All):

Clinical pharmacology.

Pharmacology, Clinical.

Medical Subjects:

Pharmacology, Clinical.

Physical Description:

xvii, 460 pages : illustrations ; 29 cm

Place of Publication:

San Diego, CA : Academic Press, 2001.

Summary:

The rate of introduction of new pharmaceutical products has increased rapidly over the past decade, and details learned about a particular drug become obsolete as it is replaced by newer agents. Principles of Clinical Pharmacology focuses on the fundamentals that underlie the clinical use and contemporary development of pharmaceuticals. The coverage of these principles in this book will be of particular benefit to individuals engaged either in the teaching or study of sound therapeutic technique or in the investigation of pharmacological agents. Key Features* Unique breadth of coverage ranging from drug discovery and development to individualization and quality assessment of drug therapy* Unusual cohesiveness of presentation that stems from author participation in an ongoing popular NIH course* Instructive linkage of pharmacokinetic theory and applications with provision of sample problems for self-study* Wide-ranging perspective of authors drawn from the ranks of Federal agencies, academia and the pharmaceutical industry

Contents:

Part I Pharmacokinetics

Chapter 2 Clinical Pharmacokinetics / Arthur J. Atkinson, Jr.

Chapter 3 Compartmental Analysis of Drug Distribution / Arthur J. Atkinson, Jr.

Chapter 4 Drug Absorption and Bioavailability / Arthur J. Atkinson, Jr.

Chapter 5 Effects of Renal Disease on Pharmacokinetics / Arthur J. Atkinson, Jr.

Chapter 6 Pharmacokinetics in Patients Requiring Renal Replacement Therapy / Arthur J. Atkinson, Jr., Gregory M. Susla

Chapter 7 Effects of Liver Disease on Pharmacokinetics / Gregory M. Susla, Arthur J. Atkinson, Jr.

Chapter 8 Noncompartmental Vs. Compartmental Approaches to Pharmacokinetic Analysis / David M. Foster

Chapter 9 Distribution Models of Drug Kinetics / Paul F. Morrison

Chapter 10 Population Pharmacokinetics / Raymond Miller

Part II Drug Metabolism and Transport

Chapter 11 Pathways of Drug Metabolism / Sanford P. Markey

Chapter 12 Methods of Analysis of Drugs and Drug Metabolites / Sanford P. Markey

Chapter 13 Clinical Pharmacogenetics / David A. Flockhart

Chapter 14 Drug Interactions / Cara L. Alfaro, Stephen C. Piscitelli

Chapter 15 Biochemical Mechanisms of Drug Toxicity / Arthur J. Atkinson, Jr., Sanford P. Markey

Chapter 16 Equilibrative and Concentrative Drug Transport Mechanisms / Peter C. Preusch

Part III Assessment of Drugs Effects

Chapter 17 Physiological and Laboratory Markers of Drugs Effect / Arthur J. Atkinson, Jr.

Chapter 18 Dose-Effect and Concentration-Effect Analysis / Elizabeth S. Lowe, Frank M. Balis

Chapter 19 Kinetic Analysis of Pharmacologic Effect / Arthur J. Atkinson, Jr.

Chapter 20 Diseases Progress Models / Nicholas H. G. Holford, Diane R. Mould, Carl C. Peck

Part IV Optimizing and Evaluating Patient Therapy

Chapter 21 Pharmacological Differences between Men and Women / Mary J. Berg

Chapter 22 Drug Therapy in Pregnant and Nursing Women / Catherine S. Stika, Marilynn C. Frederiksen

Chapter 23 Drug Therapy in Neonates and Pediatric Patients / Elizabeth Fox, Frank M. Balis

Chapter 24 Drug Therapy in the Elderly / Darrell R. Abernethy

Chapter 25 Clinical Analysis of Adverse Drug Reactions / Karim Anton Calis, Linda R. Young

Chapter 26 Quality Assessment of Drug Therapy / Charles E. Daniels

Part V Drug Discovery and Development

Chapter 27 Portfolio and Project Planning and Management in the Drug Discovery, Development, and Review Process / Charles V. Grudzinskas

Chapter 28 Drug Discovery / Robert R. Gorman

Chapter 29 Preclinical Drug Development / Chris H. Takimoto, Samir N. Khleif

Chapter 30 Animal Scale-up / Robert L. Dedrick

Chapter 31 Phase 1 Clinical Studies / Jerry M. Collins

Chapter 32 Pharmacokinetic and Pharmacodynamic Considerations in the Development of Biotechnology Products and Large Molecules / Pamela D. Garzone

Chapter 33 Design of Clinical Development Programs / Charles Grudzinskas

Chapter 34 Role of the FDA in Guiding Drug Development / Lawrence J. Lesko

Appendix I Abbreviated Table of Laplace Transforms 439.

Notes:

Includes bibliographical references and index.

Local Notes:

Acquired for the Penn Libraries with assistance from the Alumni and Friends Memorial Book Fund.

ISBN:

0120660601

OCLC:

48083877