Brain damage, brain repair / [edited] by James W. Fawcett, Anne E. Rosser, and Stephen B. Dunnett ; with additional contributions from: Harry Baker ... [and others].

Format:

Book

Author/Creator:

Fawcett, James W., 1950-

Contributor:

Rosser, Anne E.

Dunnett, S. B. (Stephen B.)

Series:

Oxford medical publications

Language:

English

Subjects (All):

Brain damage--Treatment.

Brain damage.

Cell transplantation.

Brain Damage, Chronic--therapy.

Medical Subjects:

Brain Damage, Chronic--therapy.

Physical Description:

xvii, 466 pages : illustrations ; 26 cm.

Place of Publication:

Oxford ; New York : Oxford University Press, 2001.

Summary:

Many neurological conditions are caused by damage to neurons and glial cells. For most of these diseases there are at present no effective treatments to minimize the extent of neuronal and glial loss, and no effective way of replacing what has been lost. This picture is changing rapidly. Developments in basic neuroscience have led to the development of experimental therapies capable of protecting neurons and glia following traumatic, anoxic, infectious and immunological damage. The old doctrine that axons cannot be made to regenerate, and dead neurons cannot be replaced is no longer tenable, and a wide variety of reconstructive techniques for the nervous system are under development. These and other discoveries will progress into clinical practice, and lead to a revolution in neurology and neurosurgery. This book describes the various conditions that lead to damage of the nervous system, and the ways in which they may be ameliorated. It covers the burgeoning science of reconstruction of the nervous system, through neuronal, glial and stem cell transplantation, axon regeneration, remyelination, plasticity and pharmacological interventions. The clinical applications of these techniques are described. Brain Damage, Brain Repair is the first book to cover this enormous and expanding field of neuroscience and neurology. It will be useful to students and scientists working in the field of nervous system damage and reconstruction, and also to clinicians who wish to look forward to the developments which will shape the future of their practice.

Contents:

Section I Mechanisms of Brain Damage

1 Death and Survival in the Nervous System 3

2 Axotomy and Mechanical Damage 15

3 Metabolic Damage 26

4 Inflammation and Demyelination 45

5 Infection 57

6 Neurodegenerative Disease 79

Section II Damage Limitation

7 Neuroprotection 107

8 Steroids 121

9 Trophic Factors 127

10 Control of Inflammation 139

Section III Intrinsic Mechanisms of Recovery

11 Peripheral Nerve Regeneration 145

12 Failure of CNS Regeneration 155

13 Anatomical Plasticity 171

14 Biochemical Plasticity 196

15 Remyelination 205

Section IV Clinical Assessment of Brain Damage

16 Coma 217

17 Motor, Sensory, and Autonomic Function 223

18 Cognition 243

19 Psychiatric Assessment 255

Section V Pharmacology and Rehabilitation

20 Pharmacological Management 275

21 Neuropsychological Rehabilitation 289

Section VI Structural Repair

22 Axon Regeneration in the CNS 301

23 Primary Neuronal Transplantation 313

24 Glial Transplantation 335

25 Stem Cells 344

26 Gene Therapy 357

Appendicies Specific Diseases

Appendix 1 Alzheimer's Disease 385

Appendix 2 Amyotrophic Lateral Sclerosis/Motor Neurone Disease 387

Appendix 3 Creutfeldt-Jakob Disease (CJD) 389

Appendix 4 Epilepsy 391

Appendix 5 Huntington's Disease 393

Appendix 6 Multiple Sclerosis 395

Appendix 7 Parkinson's Disease 397

Appendix 8 Spinal-cord Injury 399

Appendix 9 Stroke 401.

Notes:

Includes bibliographical references (pages [403]-456) and index.

ISBN:

0198523386

OCLC:

45661767