The liver : biology and pathobiology / editor-in-chief, Irwin M. Arias ; associate editors, James L. Boyer ... [and others].

Format:

Book

Contributor:

Arias, Irwin M.

Boyer, J. L. (James L.), 1936-

Language:

English

Subjects (All):

Liver--Physiology.

Liver.

Liver--Pathophysiology.

Liver--pathology.

Liver--physiology.

Medical Subjects:

Liver--pathology.

Liver--physiology.

Physical Description:

xvi, 1064 pages, 16 unnumbered pages of plates : illustrations (some color) ; 29 cm

Edition:

Fourth edition.

Place of Publication:

Philadelphia : Lippincott Williams & Wilkins, [2001]

Summary:

The first major text to link the discoveries of basic biology to the understanding and clinical management of liver diseases, The Liver: Biology and Pathobiology has long been a classic in gastroenterology and hepatology. Now, this landmark work has been thoroughly revised and updated to reflect recent groundbreaking achievements in the laboratory and clinic. More than 100 world-renowned investigators provide a definitive account of current concepts on the structure and function of the liver and the mechanisms underlying liver diseases. This edition has been pared down to a smaller, more user-friendly size and focused more sharply on the most important advances.

Contents:

1. Organizational Principles / Valeer J. Desmet 3

2. Embryonic Development of the Liver / Kenneth S. Zaret 17

Part II The Cells

W-1. Biology and Pathobiology of Actin in the Liver / M. James Phillips

W-2. Cytoskeleton: Intermediate Filaments / Samuel W. French

3. Gap and Tight Junctions in Liver: Composition, Regulation, and Function / Takashi Kojima, Norimasa Sawada, Heather S. Duffy, David C. Spray 29

4. Motor Molecules / Peter Satir 47

W-3. Motor Molecules of the Cytoskeleton: Possible Functions in the Hepatocyte / Peter Satir

5. Gene Regulation and In Vivo Function of Liver Transcription Factors / Robert H. Costa, Ai-Xuan Le Holterman, Francisco M. Rausa, Guy R. Adami 59

6. The Hepatocyte Plasma Membrane: Organization, Differentiation, Biogenesis, and Turnover / David Schachter 77

W-4. Plasma Membrane: Biogenesis and Turnover / Mamadi Yilla, Darrell Doyle

7. Hepatocyte Basolateral Membrane Organic Anion Transporters / Allan W. Wolkoff, Frederick J. Suchy 83

8. The Hepatocyte Surface: Dynamic Polarity / Pamela L. Tuma, Ann L. Hubbard 97

W-5. Hepatocyte Surface Polarity / Ann L. Hubbard, Valarie A. Barr, Laura J. Scott

9. The Endoplasmic Reticulum and Golgi Complex in Secretory Membrane Transport / Jennifer Lippincott-Schwartz 119

W-6. The Endoplasmic Reticulum-Golgi Membrane System / Jennifer Lippincott-Schwartz

W-7. Mechanisms of Nuclear Entry / John A. Hanover

10. Molecular Mechanisms of Hepatocellular Vesicle Formation / Sophie Dahan, Michel Dominguez, Mark A. McNiven 133

11. Receptor-Mediated Endocytosis / Richard J. Stockert 161

12. Peroxisomal Assembly, Biology, and Disease Relationship / Jennifer J. Smith, Richard A. Rachubinski 179

W-8. Peroxisomes / Paul B. Lazarow

W-9. Lysosomes / G. Gary Sahagian, Phyllis M. Novikoff

W-10. Mitochondria / Peter C. Hinkle

Section A Hepatocyte: Metabolism

W-11. Energy Metabolism / Sam Seifter, Sasha England

13. Integrated Cell Function: Apoptosis / Martina Muller, Peter H. Krammer 187

14. Fundamentals of Cellular Osmoregulation / Kevin Strange 207

15. Roles of Intracellular Proteolysis in Hepatocyte Cell-Cycle, Aging, and Programmed Cell Death / J. Fred Dice 217

16. Regulation of Hepatic Cholesterol Homeostasis / Phillip B. Hylemon, William M. Pandak, Z. Reno Vlahcevic 231

W-12. Lipoprotein Metabolism / Robert M. Glickman, Seymour M. Sabesin

17. Leptin and the Liver / Lee M. Kaplan 249

18. Hypoxic, Ischemic, and Reperfusion Injury to Liver / John J. Lemasters 257

19. Protective Mechanisms Against Reactive Oxygen Species / Masayasu Inoue 281

W-13. Reactive Oxygen Species / Masayasu Inoue

W-14. Detoxication: Oxidation and Reduction / Daniel M. Ziegler

W-15. Detoxication: Conjugation and Hydrolysis / William B. Jakoby

20. Disorders of Bilirubin Metabolism / Namita Roy Chowdhury, Irwin M. Arias, Allan W. Wolkoff, Jayanta Roy Chowdhury 291

W-16. Heme and Bile Pigment Metabolism / Jayanta Roy Chowdhury, Namita Roy Chowdhury, Allan W. Wolkoff, Irwin M. Arias

21. The Porphyrias / Peter N. Meissner, Richard J. Hift, Ralph E. Kirsch 311

W-17. Heme Biosynthesis, the Porphyrias, and the Liver / Elizabeth E. Wyckoff, James P. Kushner

22. Copper Metabolism and the Liver / Iqbal Hamza, Jonathan D. Gitlin 331

W-18. Copper and Zinc / Inmin Sternlieb

23. The Liver and Iron / Mark D. Fleming, Nancy C. Andrews 345

W-19. Liver and Iron / Stephen P. Young, Philip Aisen

W-20. Retinoid (Vitamin A) Metabolism and the Liver / William S. Blaner

W-21. Liver in Relation to Water-Soluble Vitamins / Donald B. McCormick, Hamish N. Munro

Section B Bile Secretion

24. The Biology of the Bile Canaliculus / Peter Ujhazy, Helmut Kipp, Suniti Misra, Yoshiyuki Wakabayashi, Irwin M. Arias 361

W-22. Bile Acids / Alan F. Hofmann

W-23. Enterohepatic Circulation / Martin C. Carey, William C. Duane

W-24. Bile Flow / Serge Erlinger

25. Conjugate Export Pumps of the Multidrug Resistance Protein (MRP) Family in Liver / Dietrich Keppler, Jorg Konig, Anne T. Nies 373

26. Genetic Defects of Canalicular Transport / Richard J. Thompson, Sandra S. Strautnieks 383

27. Hormonal Regulation of Bile Secretion / Francis R. Simon 389

28. Nucleotide Transport and Regulation of Bille Formation / Richard M. Roman, J. Gregory Fitz 411

29. The Pathobiology of Biliary Epithelia / Gianfranco Alpini, Richard T. Prall, Nicholas F. LaRusso 421

W-25. The Biology of Biliary Epithelia / Gianfranca Alpini, John O. Phillips, Nicholas F. LaRusso

Section C Sinusoidal Cells

30. Endothelial and Pit Cells / Filip Braet, Dianzhong Luo, Ilan Spector, David Vermijlen, Eddie Wisse 437

31. Hepatic Stellate Cells: Morphology, Function, and Regulation / Dan Li, Scott L. Friedman 455

W-26. Kupffer and Sinusoidal Endothelial Cells / Johan Kuiper, Adriaan Brouwer, Dick L. Knook, Theo J. C. van Berkel

Section D Extracellular Matrix

32. The Extracellular Matrix of the Liver / Patricia Greenwel, Marcos Rojkind 469

W-27. Extracellular Matrix / Marcos Rojkind, Patricia Greenwel

33. Integrins / Lucia R. Languino, Rebecca G. Wells 475

W-28. Cell-Extracellular Matrix Interactions / Erkki Ruoslahti, Michael D. Pierschbacher, Wayne A. Border

Part III Interrelated Cell Functions

34. Role of Inositol Trisphosphate and Diacylglycerol in the Regulation of Liver Function / John H. Exton 485

35. Synthesis of and Signaling Through D-3 Phosphoinositides / Rial A. Christensen, Isabel De Aos Scherpenseel, Lyuba Varticovski 495

36. Insulin and Other Growth Factors / M. Dodson Michael, Neil B. Ruderman 511

W-29. Insulin, Insulin-Like Growth Factors and Their Receptors / Neil Ruderman, Alan C. Moses, David E. Moller

37. Cyclic AMP Signaling in the Liver: Coupling Transcription to Physiology and Proliferation / Giuseppe Servillo, Maria Agnese Della Fazia, Paolo Sassone-Corsi 525

38. Ca[superscript 2+] Signaling in the Liver / Maria de Fatima Leite, Michael H. Nathanson 537

39. Nitric Oxide in the Liver / Mark G. Clemens 555

40. Interleukin-6 Signaling During the Acute-Phase Response of the Liver / Johannes G. Bode, Peter C. Heinrich 565

W-30. Leukotrienes and Other Eicosanoids in Liver Pathophysiology / Dietrich Keppler

41. Innate Immune Sensing and the Toll-Like Receptors / Bruce Beutler 581

42. Liver Regeneration / Nelson Fausto 591

W-31. Liver Regeneration / Nelson Fausto, Eric M. Webber

43. Hepatocyte Growth Factor: Its Role in Hepatic Growth and Pathobiology / Reza Zarnegar, Marie C. DeFrances, George K. Michalopoulos 611

Part IV The Organ

W-32. Hepatic Microvascular System / Robert S. McCuskey

W-33. Flow, Cell Entry, Metabolic Disposal, and Product Formation in the Liver / Carl A. Goresky, Andreas J. Schwab, K. Sandy Pang

Part V Relation to Other Organs

44. Hepatic Encephalopathy / Roger F. Butterworth 633

45. Alterations of the Kidney in Liver Disease / Paolo Gentilini, Giacomo Laffi, Massimo Pinzani, Giorgio La Villa 649

W-34. Kidney in Liver Disease / Murray Epstein

W-35. Interaction of Liver, Muscle, and Adipose Tissue in the Regulation of Metabolism in Response to Nutritional and Other Factors / Marc K. Hellerstein, Hamish N. Munro

W-36. Hypothalamic-Pituitary-Liver Axis: Growth Hormone Controls Liver Sex / Jan-Ake Gustafsson

W-37. Vitamin K-Dependent Blood Coagulation Proteins / Barbara C. Furie, Bruce Furie

W-38. Hemopoietic Functions of the Liver / Allan J. Erslev

W-39. Hepatobiliary Influences on the Skeletal System / Joel B. Mason, Irwin H. Rosenberg

W-40. Molecular Aspects of Aspects of Autoimmune Liver Disease / Ian R. Mackay

Part VI Pathobiologic Analysis

46. Molecular Pathophysiology of Membrane Transport Function in Cholestasis / James L. Boyer 663

47. The Biology of Portal Hypertension / Roberto J. Groszmann, Mauricio R. Loureiro-Silva, Ming-Hung Tsai 679

48. [alpha]1-Antitrypsin Deficiency / David H.

Perlmutter 699

49. Pathophysiology of Liver Fibrosis / Marcos Rojkind, Patricia Greenwel 721

50. Alcoholic and Nonalcoholic Steatohepatitis / Anna Mae Diehl 739

W-41. Ethanol and the Liver / Francis R. Weiner, Silvia Degli Esposti, Mark A. Zern

51. Schistosomiasis: A Model of Immunologically Mediated Liver Disease / Miguel J. Stadecker, Hector J. Hernandez 755

52. Immune Mechanisms of Viral Clearance and Disease Pathogenesis During Viral Hepatitis / Carlo Ferrari, Francis V. Chisari 763

53. Epidemiology, Natural History, and Prevention of Viral Hepatitis / Miriam J. Alter, Beth P. Bell 783

54. Molecular Bases of Hepatitis B

and Hepatitis C

Related Chronic Liver Disease / Christian Brechot 801

55. Molecular Biology of Hepatitis Viruses / Michael M. C. Lai, William S. Mason 831

56. Liver Transplantation: Factors Affecting the Balance Between Tolerance and Rejection in Experimental Models / Lina Lu, Shiguang Qian, Angus W. Thomson 857

W-42. The Woodchuck Model of Hepatitis B Virus Infection / Bud C. Tennant, John L. Gerin

57. Viral Hepatitis: Antiviral Therapy / Joseph Torresi, Stephen Locarnini 873

Part VII Horizons

58. Tissue Engineering of the Liver / Antonia E. Stephen, Robert Langer, Joseph P. Vacanti 901

59. A Genomic View of Hepatology: The Example of Liver Fibrosis / Jose M. Lora, Deborah N. Farlow, Nadine Weich, Jose-Carlos Gutierrez-Ramos 909

60. After Proteomics Comes Glycomics: How Proteins and Saccharides Interact and Influence Cell Biology / Ram Sasisekharan, Zachary Shriver, Uma Narayanasami, Ganesh Venkataraman 917

61. Liver Repopulation Through Cell Transplantation / David A. Shafritz, Mariana D. Dabeva, Markus Grompe 927

62. Liver-Directed Gene Therapy / Clifford J. Steer, Betsy T. Kren, Namita Roy Chowdhury, Jayanta Roy Chowdhury 941

63. Novel Strategies for Manipulating Hepatic Gene Expression In Vivo / Marxa L. Figueiredo, Eric P. Sandgren 963

64. Regulation of the Eukaryotic Cell Cycle / David F. Crawford, Helen Piwnica-Worms 977

65. Molecular and Cellular Control of Angiogenesis / Patricia A. D'Amore, Ira M. Herman 987

66. Dynamics of Hepatitis B Virus Infection / Martin A. Nowak 995

67. Telomeres and Telomerase in Experimental Liver Cirrhosis / Karl Lenhard Rudolph, Ronald A. DePinho 1001

68. Mechanism(s) of Hepatocarcinogenesis: Insight from Transgenic Mouse Models / Snorri S. Thorgeirsson 1013

69. Orphan Nuclear Receptors and Regulation of Cholesterol and Bile Acid Metabolism / Joyce J. Repa, Makoto Makishima, Timothy T. Lu, David J. Mangelsdorf 1029.

Notes:

Includes bibliographical references and index.

ISBN:

0781723906

OCLC:

45618949