Handbook of statistics in clinical oncology / edited by John Crowley.

Format:

Book

Contributor:

Crowley, John, 1946-

Language:

English

Subjects (All):

Cancer--Research--Statistical methods.

Cancer.

Clinical trials--Statistics methods.

Clinical trials.

Clinical Trials as Topic--statistics & numerical data.

Neoplasms--therapy.

Data Interpretation, Statistical.

Research Design.

Statistics--Methods.

Cancer--Research.

Medical Subjects:

Clinical Trials as Topic--statistics & numerical data.

Neoplasms--therapy.

Data Interpretation, Statistical.

Research Design.

Physical Description:

xiv, 548 pages : illustrations ; 24 cm

Place of Publication:

New York : Marcel Dekker, [2001]

Contents:

Phase I Trials

1. Overview of Phase I Trials / Lutz Edler 1

2. Dose-Finding Designs Using Continual Reassessment Method / John O'Quigley 35

3. Choosing a Phase I Design / Barry E. Storer 73

Phase II Trials

4. Overview of Phase II Clinical Trials / Stephanie Green 93

5. Designs Based on Toxicity and Response / Gina R. Petroni, Mark R. Conaway 105

6. Phase II Selection Designs / P. Y. Liu 119

Phase III Trials

7. Power and Sample Size for Phase III Clinical Trials of Survival / Jonathan J. Shuster 129

8. Multiple Treatment Trials / Stephen L. George 149

9. Factorial Designs with Time-to-Event End Points / Stephanie Green 161

10. Therapeutic Equivalence Trials / Richard Simon 173

11. Early Stopping of Cancer Clinical Trials / James J. Dignam, John Bryant, H. Samuel Wieand 189

12. Use of the Triangular Test in Sequential Clinical Trials / John Whitehead 211

Complementary Outcomes

13. Design and Analysis Considerations for Complementary Outcomes / Bernard F. Cole 229

14. Health-Related Quality-of-Life Outcomes / Benny C. Zee, David Osoba 249

15. Statistical Analysis of Quality of Life / Andrea B. Troxel, Carol McMillen Moinpour 269

16. Economic Analysis of Cancer Clinical Trials / Gary H. Lyman 291

Prognostic Factors and Exploratory Analysis

17. Prognostic Factor Studies / Martin Schumacher, Norbert Hollander, Guido Schwarzer, Willi Sauerbrei 321

18. Statistical Methods to Identify Prognostic Factors / Kurt Ulm, Hjalmar Nekarda, Pia Gerein, Ursula Berger 379

19. Explained Variation in Proportional Hazards Regression / John O'Quigley, Ronghui Xu 397

20. Graphical Methods for Evaluating Covariate Effects in the Cox Model / Peter F. Thall, Elihu H. Estey 411

21. Graphical Approaches to Exploring the Effects of Prognostic Factors on Survival / Peter D. Sasieni, Angela Winnett 433

22. Tree-Based Methods for Prognostic Stratification / Michael LeBlanc 457

Interpreting Clinical Trials

23. Problems in Interpreting Clinical Trials / Lilllian L. Siu, Ian F. Tannock 473

24. Commonly Misused Approaches in the Analysis of Cancer Clinical Trials / James R. Anderson 491

25. Dose-Intensity Analysis / Joseph L. Pater 503

26. Why Kaplan-Meier Fails and Cumulative Incidence Succeeds When Estimating Failure Probabilities in the Presence of Competing Risks / Ted A. Gooley, Wendy Leisenring, John Crowley, Barry E. Storer 513

27. Meta-Analysis / Luc Duchateau, Richard Sylvester 525.

Notes:

Includes bibliographical references and index.

ISBN:

0824790251

OCLC:

46548868