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Exploring the biological contributions to human health : does sex matter? / Committee on Understanding the Biology of Sex and Gender Differences ; Theresa M. Wizemann and Mary-Lou Pardue, editors.

Holman Biotech Commons QP81.5 .I56 2001
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Format:
Book
Author/Creator:
Institute of Medicine (U.S.). Committee on Understanding the Biology of Sex and Gender Differences.
Contributor:
Wizemann, Theresa M.
Pardue, Mary Lou.
Language:
English
Subjects (All):
Sex differences.
Sex factors in disease.
Sex Factors.
Molecular Biology.
Health.
Research Design--standards.
Sex Characteristics.
Medical Subjects:
Sex Factors.
Molecular Biology.
Health.
Research Design--standards.
Sex Characteristics.
Physical Description:
xx, 267 pages : illustrations ; 23 cm
Other Title:
Does sex matter?
Place of Publication:
Washington, D.C. : National Academy Press, [2001]
Contents:
Scope of the Report 14
Sex Differences Beyond the Reproductive System 19
Evolving Research Policy 21
Organization of Report 26
2 Every Cell Has a Sex 28
Sex and the Human Genome 29
Basic Molecular Genetics: What Is the Potential for Differences Between the Sexes? 32
Effects of Parental Imprinting on the Expression of Genetic Information 40
Unexpected or Nonobvious Sex Differences 41
Genetics as a Tool 42
Findings and Recommendations 44
3 Sex Begins in the Womb 45
Biology of Sex 46
Early Development 50
Puberty 62
Adulthood 72
Findings and Recommendations 77
4 Sex Affects Behavior and Perception 79
Sex Differences in Behavior and Cognitive Abilities 79
Effects of Hormones on Behavior and Cognition 89
Sex Differences in Perception of Pain 105
Animal Models of Cerebrovascular and Cardiovascular Diseases 112
Findings and Recommendations 115
5 Sex Affects Health 117
Sex Differences in Response to Therapeutic Agents: Diagnostic and Therapeutic Interventions 118
Metabolism, Lifestyle, and Physical Performance 130
Sex Differences in Autoimmune Conditions 142
A Spectrum of Sex Differences Across a Disease: Coronary Heart Disease 158
Findings and Recommendations 170
6 The Future of Research on Biological Sex Differences: Challenges and Opportunities 173
Terminology 174
Research Tools and Resources 176
Interdisciplinary and Collaborative Research 181
Non-Health-Related Implications of Research on Sex Differences in Health 183
A Data Sources and Acknowledgments 229
B Physiological and Pharmacological Differences Between the Sexes 233
D Committee and Staff Biographies 243
3-1 Some Genes Involved in Human Sex Determination 53
3-2 Selected Examples of Variations in Sexual Differentiation 63.
Notes:
Includes bibliographical references (185-228) and index.
ISBN:
0309072816
OCLC:
46873005

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