Neuropathology and genetics of dementia / edited by Markus Tolnay and Alphonse Probst.

Format:

Book

Contributor:

Tolnay, Markus, 1962-

Probst, Alphonse, 1938-

Series:

Advances in experimental medicine and biology ; v. 487.

Advances in experimental medicine and biology ; v. 487

Language:

English

Subjects (All):

Dementia--Pathophysiology--Congresses.

Dementia.

Dementia--Genetic aspects--Congresses.

Nervous system--Pathophysiology--Congresses.

Nervous system.

Dementia--physiopathology.

Nervous system--Pathophysiology.

Physiology, Pathological.

Dementia--genetics.

Nervous System--physiopathology.

Medical Subjects:

Dementia--physiopathology.

Dementia--genetics.

Nervous System--physiopathology.

Genre:

Conference papers and proceedings.

Physical Description:

xiii, 255 pages : illustrations ; 26 cm.

Place of Publication:

New York : Kluwer Academic/Plenum Publishers, [2001]

Summary:

This volume is the proceedings from the Swiss Society for Neuropathology XVIIIth International Winter Meeting on Neuropathology and Genetics of Dementia, held March 23-26, 2000, in St. Moritz, Switzerland. For more than 35 years the Swiss Society of Neuropathology has organised its traditional International Winter Meeting, whose main aim is to bring together neuropathologists and clinicians as well as neuroscientists interested in disease mechanisms. The topic of the 2000 Meeting was Neuropathology and Genetics of Dementia . A programme of invited plenary lectures of high educational value as well as platform and poster presentations given by many participants covered the broad spectrum of dementing disorders. Encouraged by the high standard of the meeting, and probably also influenced by the advent of a new Millennium, it was decided to publish the Proceedings of the 2000 Meeting in the present book.

Contents:

Can the Physician Predict the Neuropathologist? / Martin N. Rossor 1

The Molecular Parameters of Tau Pathology: Tau as a killer and a witness / Andre Delacourte 5

Tau Gene Mutations and Tau Pathology in Frontotemporal Dementia and Parkinsonism Linked to Chromosome 17 / Maria G. Spillantini, Michel Goedert 21

Argyrophilic Grain Disease: A frequent dementing disorder in aged patients / Markus Tolnay, Andreas U. Monsch, Alphonse Probst 39

Tau Pathology in Neurons and Glial Cells of Aged Baboons / Christian Schultz, Gene B. Hubbard, Kelly Del Tredici, Eva Braak, Heiko Braak 59

Human Tau Transgenic Mice: Towards an animal model for neuro- and glialfibrillary lesion formation / Jurgen Gotz, Markus Tolnay, Robi Barmettler, Alessandra Ferrari, Kurt Burki, Michel Goedert, Alphonse Probst, Roger M. Nitsch 71

Regulation of Alzheimer [beta]-Amyloid Precursor Trafficking and Metabolism / Samuel Gandy, Suzana Petanceska 85

Role of Type 10 17[beta]-Hydroxysteroid Dehydrogenase in the Pathogenesis of Alzheimer's Disease / Song-Yu Yang, Xue-Ying He 101

The Spectrum of Vascular Disease in Dementia: From ischemia to amyloid angiopathy / Roy O. Weller, Stephen D. Preston 111

Transgenic Mouse Models of Cerebral Amyloid Angiopathy / Martin C. Herzig, David T. Winkler, Lary C. Walker, Mathias Jucker 123

Alpha-Synuclein: Axonal transport, ligand interaction and neurodegeneration / Poul Henning Jensen, Wei Ping Gai 129

Dementia with Lewy Bodies / Paul Ince 135

Mouse Models of [alpha]-Synucleinopathy and Lewy Pathology: [alpha]-synuclein expression in transgenic mice / Samuel Barbieri, Katja Hofele, Karl-Heinz Wiederhold, Alphonse Probst, Claudia Mistl, Simone Danner, Sabine Kauffmann, Bernd Sommer, Willibrordus Spooren, Markus Tolnay, Graeme Bilbe, Herman van der Putten 147

Ubiquitin and the Molecular Pathology of Neurodegenerative Diseases / James Lowe, John Mayer, Michael Landon, Robert Layfield 169

Perisomatic Granules of Hippocampal Ca1 Neurons in Alzheimer's Disease, Pre-Alzheimer Stage and Pick's Disease: an Overlooked Pathological Entity / Alphonse Probst, Claudia Mistl, Sabine Ipsen, Markus Tolnay 187

Pathological Mechanisms in Polyglutamine Expansion Diseases / Didier Devys, Gael Yvert, Astrid Lunkes, Yvon Trottier, Jean-Louis Mandel 199

Dementia in the Neuronal Ceroid-Lipofuscinoses / Hans H. Goebel, Alfried Kohlschutter 211

Neurodegeneration-Associated Proteins and Inflammation in Sporadic Inclusion-Body Myositis / Johannes B. Lampe, Maggie C. Walter, Heinz Reichmann 219

Mitochondrial Dysfunction in Neurodegenerative Disorders and Ageing / Christopher Turner, Anthony H.V. Schapira 229.

ISBN:

0306465582

OCLC:

45463395