Healthy aging for functional longevity : molecular and cellular interactions in senescence / edited by Sang Chul Park ... [and others].

Format:

Book

Contributor:

Park, Sang Chul.

International Association of Biomedical Gerontology.

Series:

Annals of the New York Academy of Sciences ; v. 928.

Annals of the New York Academy of Sciences ; v. 928

Language:

English

Subjects (All):

Aging--Molecular aspects--Congresses.

Aging.

Aging--Molecular aspects.

Longevity--Congresses.

Longevity.

Aging--physiology.

Cellular Senescence.

Medical Subjects:

Aging--physiology.

Cellular Senescence.

Longevity.

Genre:

Conference papers and proceedings.

Physical Description:

xii, 389 pages : illustrations ; 24 cm.

Place of Publication:

New York : New York Academy of Sciences, 2001.

Contents:

Part I. Main Theme of Current Aging Research

Aging: Overview / Denham Harman 1

Protein Oxidation in Aging and Age-Related Diseases / Earl R. Stadtman 22

Stress Resistance by Caloric Restriction for Longevity / Byung P. Yu, Hae Young Chung 39

Part II. Biomedical Changes Associated with Aging

Protein Glycation: Creation of Catalytic Sites for Free Radical Generation / Moon B. Yim, Hyung-Soon Yim, Cheolju Lee, Sa-Ouk Kang, P. Boon Chock 48

Implications of Protein Degradation in Aging / Sataro Goto, Ryoya Takahashi, Atsushi Kumiyama, Szolt Radak, Toshiaki Hayashi, Masaki Takenouchi, Ryoichi Abe 54

Transglutaminase-Mediated Crosslinking of Specific Core Histone Subunits and Cellular Senescence / Jae Hong Kim, Hyon E Choy, Kang Hoon Nam, Sang Chul Park 65

Proteome and Proteomics for the Research on Protein Alterations in Aging / Tosifusa Toda 71

Attenuation of EGF Signaling in Senescent Cells by Caveolin / Woong-Yang Park, Kyung-A Cho, Jeong-Soo Park, Deok-In Kim, Sang Chul Park 79

Part III. Genomic Instability in Aging

BRCA1 Gene Sequence Variation in Centenarians / Jan Vijg, Thomas Perls, Claudio Franceschi, Nathalie J. van Orsouw 85

Increases of Mitochondrial Mass and Mitochondrial Genome in Association with Enhanced Oxidative Stress in Human Cells Harboring 4,977 BP-Deleted Mitochondrial DNA / Yau-Huei Wei, Cheng-Feng Lee, Hsin-Chen Lee, Yi-Shing Ma, Chia-Wen Wang, Ching-You Lu|cCheng-Yoong Pang 97

DNA Polymerase-[beta] May Be the Main Player for Defective DNA Repair in Aging Rat Neurons / Kalluri Subba Rao, V.V. Annapurna, N.S. Raji 113

Premature Aging and Predisposition to Cancers Caused by Mutations in RecQ Family Helicases / Yasuhiro Furuichi 121

Health Span and Life Span in Transgenic Mice with Modulated DNA Repair / Christi A. Walter, Zi-Qiang Zhou, Diwi Manguino, Yuji Ikeno, Robert Reddick, James Nelson, Gabriel Intano, Damon C. Herbert, C. Alex McMahan, Martha Hanes 132

Part IV. Cellular Maintenance and Stress Response

Inhibition Mechanisms of Bioflavonoids Extracted from the Bark of Pinus maritima on the Expression of Proinflammatory Cytokines / Kyung-Joo Cho, Chang-Hyun Yun, Lester Packer, An-Sik Chung 141

Gene Expression and Regulation in the Extended Longevity Phenotypes of Drosophila / Robert Arking 157

Impairment of Learning and Memory in Rats Caused by Oxidative Stress and Aging, and Changes in Antioxidative Defense Systems / Koji Fukui, Koji Onodera, Tadashi Shinkai, Shozo Suzuki, Shiro Urano 168

Translocational Inefficiency of Intracellular Proteins in Senescence of Human Diploid Fibroblasts / In Kyoung Lim, Kwang Won Hong, In Hae Kwak, Gyesoon Yoon, Sang Chul Park 176

Oxidative Stress and Neurodegeneration in Prion Diseases / Jae-Il Kim, Seung-Il Choi, Nam-Ho Kim, Jae-Kwang Jin, Eun-Kyoung Choi, Richard I. Carp, Yong-Sun Kim 182

On the True Role of Oxygen Free Radicals in the Living State, Aging, and Degenerative Disorders / Imre Zs.-Nagy 187

Cellular and Molecular Pathogenic Mechanisms of Insulin-Dependent Diabetes Mellitus / Ji-Won Yoon, Hee-Sook Jun 200

Part V. Practical Approach for Functional Longevity

Capacity for Recovery and Possible Mechanisms in Immobilization Atrophy of Young and Old Animals / N. Zarzhevsky, O. Menashe, E. Carmeli, H. Stein, A.Z. Reznick 212

Nutrition Interventions in Aging and Age-Associated Disease / Mohsen Meydani 226

Exercise at Old Age: Does It Increase or Alleviate Oxidative Stress? / Li Li Ji 236

Do Antioxidant Strategies Work against Aging and Age-associated Disorders? Propargylamines: A Possible Antioxidant Strategy / Kenichi Kitani, Chiyoko Minami, Takako Yamamoto, Wakako Maruyama, Setsuko Kanai, Gwen O. Ivy, Maria-Cristina Carrillo 248

Antioxidant and Immunostimulating Activities of the Fruiting Bodies of Paecilomyces japonica, a New Type of Cordyceps sp / Kuk Hyun Shin, Soon Sung Lim, Sang Hyun Lee, Yeon Sil Lee, Sae Yun Cho 261

A New Function of Green Tea: Prevention of Lifestyle-related Diseases / Naoko Sueoka, Masami Suganuma, Eisaburo Sueoka, Sachiko Okabe, Satoru Matsuyama, Kazue Imai, Kei Nakachi, Hirota Fujiki 274

Anti-aging and Health-promoting Constituents Derived from Traditional Oriental Herbal Remedies: Information Retrieval Using the TradiMed 2000 DB / Il-Moo Chang 281

Part VI. Calorie Restriction and Longevity

Caloric Restriction in Primates / M. A. Lane, A. Black, A. Handy, E.M. Tilmont, D. K. Ingram, G. S. Roth 287

Calorie Restriction Enhances the Expression of Key Metabolic Enzymes Associated with Protein Renewal during Aging / Stephen R. Spindler 296

Caloric Restriction in Primates and Relevance to Humans / George S. Roth, Donald K. Ingram, Mark A. Lane 305

Aging and Caloric Restriction in Nonhuman Primates: Behavioral and in Vivo Brain Imaging Studies / Donald K. Ingram, Svetlana Chefer, John Matochik, Tammy D. Moscrip, James Weed, George S. Roth, Edythe D. London, Mark A. Lane 316

The Inflammation Hypothesis of Aging: Molecular Modulation by Calorie Restriction / Hae Young Chung, Hyon Jeen Kim, Jung Won Kim, Byung Pal Yu 327

Panel Discussion: Perspectives in Aging Research in the New Millennium / Sang Chul Park, Chair 336

A Thermolabile Variant of Methylenetetrahydrofolate Reductase Is a Determinant of Hyperhomocyst(e)inemia in the Elderly / Jun-Hyun Yoo 344

Age-related Increase in the Expression of Heat-Shock Protein Genes in the Tissues of Unstressed Rats / Ryoya Takahashi, Sataro Goto 345

Amyloid-[beta]-Peptide 25-35 Fragment Modulates the Expression of the Mitochondrial Cytochrome Oxidase Gene / Bok-Ghee Han, Eun Hye Han, Jeung Yeub Ahn, Jungsoon Park 346

Analysis of the Cell Distribution of Endogenous Murine Leukemia Virus in the Brains of SAMR1 and SAMP8 Mice / Byung-Hoon Jeong, Jae-Kwang Jin, Eun-Kyoung Choi, H.C. Meeker, Christine A. Kozak, Richard I Carp, Yong-Sun Kim 347

Analysis of Traditional Korean Food Patterns According to the Healthy Longevity Diet Based on the Database of Favorite Korean Foods / Mee-Sook Lee, Mee-Kyung Woo, Chung-Shil Kwak, Se-In Oh, Sang-Chul Park 348

Analysis of Proteins in Aged Rat Kidney: The Effect of Calorie Restriction / Hyon-Jeen Kim, Hyeon-Young Jeong, Byung-Pal Yu, Sataro Goto, Hae-Young Chung 349

Analysis of Redox Status in Serum during Aging / Jung-Won Kim, Jae-Kyung No, Byung-Pal Yu, Hae-Young Chung 350

Animal Model for Alzheimer's Disease by PS2 Gene Transfer / Dae-Youn Hwang, Kap-Ryong Chae, Tae-Surk Kang, Dong-Hwan Shin, In-Surk Jang, Jin-Hee Hwang, Yeon-Ju Kim, Joon-Yong Cho, Bum-Jin Kim, Yong-Kyu Kim, Jung-Sik Cho 351

Changes in Growth Factor-induced Signal Transduction during the Aging Process of Human Primary Fibroblasts / Eui-Ju Yeo, Chang-Mo Kang 352

Contribution of Cyclooxygenase to Age-related Oxidative Stress / Hyon-Jeen Kim, Byung-Pal Yu, Mi-Ae Yu, Kyu-Won Kim, Jae-Suk Woo, Hae-Young Chung 353

Control of Mitochondrial Redox Balance by the Mitochondrial NADP[superscript +]-dependent Isocitrate Dehydrogenase / Tae-Lin Huh, Seung-Hee Jo, Mi-Kyung Sohn, Su-Min Lee, In-Hwang Song, Ho-Jin Koh, Yong-Ou Kim, Jeen-Woo Park 354

The Pro- and Antioxidant Role of Glutathione in Selenite-induced Oxidative Stress and Apoptosis / Han-Ming Shen, Cheng-Feng Yang, Jin Liu, Choon-Nam Ong 355

Effects of Aging on Aldosterone Secretion in Rat Zona Glomerulosa Cells / Mei-Mei Kau, Jiann-Jong Chen, Paulus S. Wang 356

Evidence for Differential Structure and Function of Hsp70 Family Members, Mot-1 and Mot-2, in Control of Cellular Senescence / Youji Mitsui, Renu Wadhwa, Syuichi Takano, Sunil C.

Kaul 357

Expression of Growth-Related Genes in the Tissues of Aged Rat Brain / Deok-Kyu An, Seon-Gil Do, Jun-Gyo Suh, Jae-Bong Park, Jae-Yong Lee 358

Expression of Peroxiredoxin in the Skin and Change of Peroxiredoxin by Ultraviolet B Irradiation: A Possible Antioxidant Role against Oxidative Stress in the Skin / Seung-Chul Lee, Jung Eun Lee, Jee-Bum Lee, Young Pio Kim, Ho Zoon Chae 359

Genetic Polymorphism of Presenilin-1 Gene and Apolipoprotein E in Korean Elderly with Dementia / Jung-Eun Park, Kyung-Hea Cho 361

Impact of Growth Hormone Suppression in the Aging Process and Preliminary Longevity Analysis / Isao Shimokawa, Yoshikazu Higami, Kurumi Yanagihara-Outa, Kenji Tanaka, Tomoshi Tuchiya, Takahito Kondo, Shinji Goto 362

Increased Expression of Calsenilin in the Brains of Scrapie-infected Mice / Jin-Kyu Choi, Hyun-Pil Lee, Eun-Kyoung Choi, Jae-Kwang Jin, Hyoung-Gon Lee, Wilma Wasco, Joseph D. Buxbaum, Richard I. Carp, Yong-Sun Kim 363

Induction of Cellular Senescence in Cervical Cancer Cells by Inhibition of HPV Oncogene Expression / Chan Jae Lee, Eun Seong Hwang 364

Induction of Senescence-like Phenotype by an Alkylating Agent, Methyl Methanesulfonante, in Human Diploid Fibroblast / Yousin Suh, Deok-In Kim, Jeong-Soo Park, Woong-Yang Park, Sang Chul Park 365

Investigation on Natural Peroxynitrite Scavengers / Ji-Sung Yoon, Byung-Pal Yu, Hae-Young Chung 366

Involvement of Caspases in Cell Death Induced by Selenium Compounds in HL-60 Cells / Uhee Jung, Tae-Ho Kim, An-Sik Chung 367

Lowered 8-Hydroxyguanine Glycosylase Activity in Senescence-accelerated Mice due to a Single-base Mutation / Jeong-Yun Choi, Hun-Sik Kim, Dong-Wook Lee, Myung-Hee Chung 368

Melatonin-related Compounds Have High Free Radical Scavenging Activity / Ryung Yang, Hae-Young Chung, Dong-Bum Shin, Tae-Yeon Cho, Seung-Hyun Yang 369

Metabolic Modulation of Cellular Redox Potential Can Improve Cardiac Recovery from Ischemia-Reperfusion Injury / Heun-Soo Kang, Jong-Wan Park, Yang-Sook Chun, Myung-Suk Kim, Sang Chul Park 370

New Directions in Communicating Better Nutrition to Older Adults / Georgia Sue Guldan, Wendy Wai-Hing Hui 371

Nitric Oxide Is Implicated in Apoptotic Cell Death Induced by H[subscript 2]O[subscript 2] in C6 Cells / Young Il Lee, Jungsoon Park, Young Hee Lee, Bok-Ghee Han 372

Overexpression of Calsenilin in Sporadic Alzheimer's Disease Brain / Jae Kwang Jin, Jin Kyu Choi, Jae Il Kim, Hyoung Gon Lee, Wilma Wasco, Joseph D. Buxbaum, Richard I. Carp, Yong-Sun Kim, Eun Kyoung Choi 373

Oxidative Stress Associated Antioxidant Enzyme and Neuroendocrine Markers in Dementia / Heui Og Kim, Hye Won Seo, Jung Eun Park, Kyung Hea Cho, In Sung Kim 374

p38 Mitogen-activated Protein Kinase Is Involved in H[subscript 2]O[subscript 2]-induced Phospholipase D Activation in Vascular Smooth Muscle Cells / Eung-Gook Kim, Eun-Young Shin, Do Sik Min, Byoung-Hee Park, Kyung-Sun Shin, Min-Soo Hyun, Ji-Cheol Shin, Hee-Yul Ahn, Roger J. Davis, Seung-Ryul Kim 376

Photoaging in Asian Skin: New Grading System and the Influence of Environmental Factors / Jin Ho Chung, Seong Hun Lee, Choon Shik Yoon, Hee Chul Eun 377

Plasma Concentrations of an Endogenous Nitric Oxide Synthase Inhibitor, N[superscript G],N[superscript G]-Dimethylarginine: A Novel Risk Factor for Cerebral Infarction in the Elderly / Jun-Hyun Yoo, Sung-Chang Lee 378

Protection of Mitochondria Permeability Transition by Dihydroxybenzaldehyde against Hydroxyl Radicals / Hae Young Chung, Hyon Jeen Kim, Young Hwan Yang, Won Chul Choi, Hye Jin Park, Jae Sue Choi, Chang Mo Kang, Sang Chul Park 379

Risk Factors for Total Mortality in Centenarians in Aichi Prefecture, Japan / Kiyoko Yagyu, Shogo Kikuchi, Hisashi Tauchi 380

The Activation Mechanisms of NF-[kappa]B and Inflammatory Enzymes during Aging / Hyun Joo Kwon, Hyon Jeen Kim, Min Ju Kang, Ryoya Takahashi, Sataro Goto, Byung Pal Yu, Hae Young Chung 381

Vitamin and Mineral Supplement Use among Independent-living Korean and American Older Adults / Seung-Youn Hong 382

Vitamin D and Estrogen Receptor Gene Polymorphism and Their Interaction Associated with Bone Mineral Density in Korean Postmenopausal Women / In Soon Kwon, Taiwoo Yoo, Byung Joo Park, Heung Sik Kang, Chang Mo Kang, In Kyu Kim, Sang Hoon Bae, Hyun Chan Cho, Haeng Shin Lee, Cho-Il Kim 384

Vitamin-E Dose-Associated Alterations in Mouse Immune Function / Hyun-Sook Kim, Ji-Hye Lee, You-Sook Lee 385.

Notes:

"This volume is the result of a conference entitled Healthy aging for functional longevity: molecular and cellular interations in senescence held by the International Association of Biomedical Gerontology on February 21-24, 2000 in Kyongju, South Korea."

Includes bibliographical references and index.

ISBN:

1573312851

157331286X

OCLC:

45757856