Endocytosis / edited by Mark Marsh.

Format:

Book

Contributor:

Marsh, Mark.

Class of 1932 Fund.

Series:

Frontiers in molecular biology

Language:

English

Subjects (All):

Endocytosis.

Physical Description:

xxi, 283 pages, 4 unnumbered pages of plates : illustrations (some color) ; 26 cm.

Place of Publication:

Oxford ; New York : Oxford University Press, 2001.

Contents:

1 Clathrin-mediated endocytosis / Shu-Hui Liu, William G. Mallet, Frances M. Brodsky 1

2. History and biochemistry 2

3. Mechanism of CCV formation during receptor-mediated endocytosis 8

4. Regulation of clathrin-mediated endocytosis 11

5. Advances in the resolution of coat protein structures 14

6. Methods for studying clathrin-mediated endocytosis 16

2 Cathrin-independent endocytosis / Alice Dautry-Varsat 26

2. Evidence in favour of clathrin-independent endocytosis: the morphological approach 26

3. Inhibition of clathrin-dependent endocytosis to detect clathrin-independent endocytosis 27

3.1 Pharmacological methods 28

3.2 The use of dominant negative mutants of endocytosis 30

4. Multiple clathrin-independent pathways? 38

4.1 Macropinocytosis 39

4.2 Caveolae 39

4.3 Other pathways 43

4.4 Later steps along the endocytic pathway 46

4.5 Potential functions 47

3 Phagocytosis / Emmanuelle Caron, Alan Hall 58

2. Phagocytes 58

3. Phagocytic receptors 59

4. Cell biology of phagocytosis 61

4.1 Ultrastructural changes associated with internalization 61

4.2 Cytoskeletal reorganization during phagocytosis 63

4.3 Phagosome maturation 64

4.4 Phagocytosis and endocytosis 65

5. Signal transduction of phagocytosis 66

5.1 Tyrosine kinases 66

5.2 Phosphatidylinositol 3-kinase (PI3K) 67

5.3 Small GTP-binding proteins 67

5.4 Other signalling pathways 69

6. Functional, physiological, and pathological consequences of phagocytosis 70

4 Macropinocytosis / Markus Maniak 78

2. Macropinocytosis or other pathways? 79

3. Physiological stimulus or cells gone wild? 80

4. Reorganization of the cytoskeleton or redirected vesicle traffic? 82

4.1 The actin cytoskeleton 82

4.2 Microtubules and vesicle transport 84

5. Recycling or progression? 84

6. Biological function or accidental event? 85

5 Molecular mechanisms of membrane fusion in the endocytic pathway / Harald Stenmark, Marino Zerial 94

2. Experimental systems to study endocytic membrane docking and fusion 94

3. Rab GTPases and SNAREs in membrane docking and fusion 96

4. Rab5 and its effectors in early-endosome fusion 98

5. PI 3-kinase and endocytic membrane fusion 101

6. EEA1 and SNARE complex formation 103

7. Conservation of the endocytic membrane fusion machinery 104

6 Lysosomes and other late compartments of the endocytic pathway / Matthew N. J. Seaman, J. Paul Luzio 111

2. The heterogeneity of lysosomes 112

3. The endocytic pathway to lysosomes 113

4. The delivery of endocytosed material from late endosomes to lysosomes 114

5. The mechanism of fusion of late endosomes and lysosomes 116

6. Lysosome recovery from hybrid organelles 118

7. The biosynthetic route to the yeast vacuole 118

8. Delivery of newly synthesized proteins to mammalian lysosomes 126

9. The AP-3 route to lysosomes and lysosome-like organelles 127

10. Autophagy 129

11. The impact of the genetics of multicellular organisms on understanding lysosome biogenesis 134

12. The effect of toxins on late endocytic organelles 136

7 Sorting and sorting signals in the endocytic pathway / Stefan Honing 149

2. Sorting of membrane proteins during receptor-mediated endocytosis 149

3. Entry into the endocytic pathway via the TGN 152

4. Sorting from endosomes to the TGN 153

5. Sorting from endosomes to the plasma membrane 156

6. Sorting en route to lysosomes 157

7. Sorting within the endosomal system of polarized cells 161

8. Conclusions and future directions 162

8 Endocytosis and antigen presentation / Monique J. Kleijmeer, Graca Raposo 168

2. Entry of antigen into antigen presenting cells 169

2.1 Uptake via the B cell antigen receptor 169

2.2 Properties of FcRs 172

2.3 Internalization mechanisms of macrophages and DCs 172

3. Processing of antigens in the endocytic pathway 174

4. An overview of the biosynthetic pathway of MHC II molecules: association with invariant chain, HLA-DM, and HLA-DO 176

4.1 Biosynthesis of MHC II molecules 177

4.2 Delivery of MHC II molecules to the endocytic pathway by Ii 177

4.3 Role of DM and DO in peptide loading 179

5. Targeting MHC II molecules to the endocytic pathway 180

6. The intracellular compartments involved in antigen processing and presentation: an adaptation of the endocytic pathway? 182

6.1 Identification of MHC II-enriched compartments (MIICs) 182

6.2 Specialized peptide loading compartments 184

7. Transport of MHC II molecules to the cell surface 185

7.1 Direct fusion of multivesicular MIICs with the cell surface 186

7.2 Characteristics of exosomes 186

7.3 Additional pathways for the transfer of MHC II to the cell surface 188

9 Synaptic vesicle recycling: multiple pathways and functions in the nervous system / Patrick Wigge, Harvey T. Mcmahon 204

1. Overview: potential functions of synaptic vesicle recycling in the nervous system 204

2. Pathways of synaptic vesicle recycling 205

2.1 Evidence for clathrin-mediated endocytosis 206

2.2 Evidence for kiss-and-run endocytosis 207

2.3 How might the two pathways coexist? 208

3. Regulatoery cues influencing synaptic endocytosis 208

4. Potential roles of endocytosis in learning and memory 210

4.1 Endocytosis determines cell-surface expression of neuronal CAMs 210

4.2 Endocytosis proteins, neurite outgrowth, and long-term depression 212

4.3 Postsynaptic endocytosis: dynamin-dependent uptake of AMPA receptors 213

10 Endocytosis in Saccharomyces cerevisiae: involvement of actin, actin-associated protein complexes, and lipids in the internalization step / Ruben Lombardi, Sylvie Friant, Howard Riezman 218

2. Techniques used to study endocytosis in yeast 222

2.1 Fluid phase endocytosis 222

2.2 Receptor-mediated endocytosis 223

3. Actin and actin-associated proteins 225

3.1 The actin cytoskeleton 225

3.2 Actin-associated proteins 226

4. Involvement of clathrin in endocytosis 230

5. Role of lipids in the endocytic pathway 232

5.1 Lipid requirement in membrane trafficking in yeast 232

5.2 Lipid requirement in endocytosis 233

6. Outlook 237

11 Endocytosis in pathogen entry and replication / David G. Russell, Mark Marsh 247

2. Viral interactions with the endocytic pathway 247

2.1 Virus endocytosis 248

2.2 Endocytosis in virus assembly 256

3. Bacterial and protozoan pathogens 257

3.1 Host cell entry 257

3.2 Post entry 259

4. Modulating the immune response 266

4.1 Viral regulation of cell surface antigen expression 266

4.2 Modification of the immune response by bacterial and protozoal pathogens 267.

Notes:

Includes bibliographical references and index.

Local Notes:

Acquired for the Penn Libraries with assistance from the Class of 1932 Fund.

ISBN:

0199638527

0199638519

OCLC:

45284713