1 option
Electrochemotherapy, electrogenetherapy, and transdermal drug delivery : electrically mediated delivery of molecules to cells / edited by Mark J. Jaroszeski, Richard Heller, Richard Gilbert.
Holman Biotech Commons QH585.5.E48 E434 2000
Available
- Format:
- Book
- Series:
- Methods in molecular medicine ; 37.
- Methods in molecular medicine ; 37
- Language:
- English
- Subjects (All):
- Electroporation.
- Transdermal medication.
- Bioelectrochemistry.
- Cancer--Chemotherapy.
- Cancer.
- Administration, Cutaneous.
- Electrochemistry.
- Neoplasms--drug therapy.
- Medical Subjects:
- Electroporation.
- Administration, Cutaneous.
- Electrochemistry.
- Neoplasms--drug therapy.
- Physical Description:
- xiii, 497 pages : illustrations (some color) ; 23 cm.
- Place of Publication:
- Totowa, N.J. : Humana Press, [2000]
- Summary:
- Reviews all aspects of the delivery of therapeutic molecules to cells using electrical impulse. Surveys basic physical principles that govern cell permeabilization by pulsed electric fields, describes instrumentation and electrodes, and summarizes preclinical and clinical trial results. Focuses on drug, gene, and transdermal delivery techniques, providing detailed examples of drug delivery using electric fields from a variety of pulse generators and electrodes.
- Contents:
- 1 Principles of Membrane Electroporation and Transport of Macromolecules / Eberhard Neumann, Sergej Kakorin, Katja Toensing 1
- 2 Instrumentation and Electrodes for In Vivo Electroporation / Gunter A. Hofmann 37
- 3 Numerical Modeling for In Vivo Electroporation / Dejan Semrov, Damijan Miklavcic 63
- 4 In Vitro Delivery of Drugs and Other Molecules to Cells / Marie-Pierre Rols, Muriel Golzio, Christine Delteil, Justin Teissie 83
- 5 The Basis of Electrochemotherapy / Lluis M. Mir, Stephane Orlowski 99
- 6 Electrochemotherapy: Animal Model Work Review / Gregor Sersa 119
- 7 Clinical Trials for Solid Tumors Using Electrochemotherapy / Richard Heller, Richard Gilbert, Mark J. Jaroszeski 137
- 8 In Vitro and Ex Vivo Gene Delivery to Cells by Electroporation / Sek Wen Hui, Lin Hong Li 157
- 9 Delivery of Genes In Vivo Using Pulsed Electric Fields / Mark J. Jaroszeski, Richard Gilbert, Claude Nicolau, Richard Heller 173
- 10 Mechanism of Transdermal Drug Delivery by Electroporation / Timothy E. Vaughan, James C. Weaver 187
- 11 Mechanistic Studies of Skin Electroporation Using Biophysical Methods / Mark R. Prausnitz, Uwe Pliquett, Rita Vanbever 213
- Electrochemotherapy Protocols
- 12 Treatment of Murine Transplanted Subcutaneous Tumors Using Systemic Drug Administration / Stephane Orlowski, Lluis M. Mir 247
- 13 Electrochemotherapy of Murine Melanoma Using Intratumor Drug Administration / Richard Heller, Richard Gilbert, Mark J. Jaroszeski 253
- 14 Treatment of a Tumor Model with ECT Using 4+4 Electrode Configuration / Maja Cemazar 259
- 15 Treatment of Multiple Spontaneous Breast Tumors in Mice Using Electrochemotherapy / Stephane Orlowski, Lluis M. Mir 265
- 16 Electroporation of Muscle Tissue In Vivo / Julie Gehl, Lluis M. Mir 271
- 17 Treatment of Human Pancreatic Tumors Xenografted in Nude Mice by Chemotherapy Combined with Pulsed Electric Fields / Sukhendu B. Dev, Gunter A. Hofmann, Gurvinder S. Nanda 277
- 18 Distribution of Bleomycin in a Rat Model / Per Engstrom, Leif G. Salford, Bertil R. R. Persson 285
- 19 Treatment of Rat Bladder Cancer with Electrochemotherapy In Vivo / Yoko Kubota, Teruhiro Nakada, Isoji Sasagawa 293
- 20 Electrochemotherapy for the Treatment of Soft Tissue Sarcoma in a Rat Model / Richard Gilbert, Mark J. Jaroszeski, Richard Heller 299
- 21 Treatment of Spontaneous Soft Tissue Sarcomas in Cat / Stephane Orlowski, Lluis M. Mir 305
- 22 Treatment of Rat Glioma with Electrochemotherapy / Leif G. Salford, Per Engstrom, Bertil R. R. Persson 313
- 23 Treatment of Liver Malignancies with Electrochemotherapy in a Rat Model / Mark J. Jaroszeski, Richard Gilbert, Richard Heller 319
- 24 Treatment of Liver Tumors in Rabbit / Stephane Orlowski, Lluis M. Mir 327
- Electrogenetherapy Protocols
- 25 Electrically Mediated Reporter Gene Transfer into Normal Rat Liver Tissue / Mark J. Jaroszeski, Richard Gilbert, Claude Nicolau, Richard Heller 333
- 26 Reporter/Functional Gene Transfer in Rat Brain / Toru Nishi, Kimio Yoshizato, Tomoaki Goto, Hideo Takeshima, Shigeo Yamashiro, Jun-ichi Kuratsu, Hideyuki Saya, Yukitaka Ushio 339
- 27 In Vivo Gene Electroporation in the Mouse Testis / Tatsuo Muramatsu 349
- 28 Ex Vivo Stromal Cell Electroporation of Factor IX cDNA for Treatment of Hemophilia B / Armand Keating, Edward Nolan, Robin Filshie, Sukhendu B. Dev 359
- 29 In Ovo Gene Electroporation into Early Chicken Embryos / Tatsuo Muramatsu 369
- Transdermal Delivery Protocols
- 30 Electrical Impedance Spectroscopy for Rapid and Noninvasive Analysis of Skin Electroporation / Uwe Pliquett, Mark R. Prausnitz 377
- 31 An In Vitro System for Measuring the Transdermal Voltage and Molecular Flux Across the Skin in Real Time / Tani Chen, Robert Langer, James C. Weaver 407
- 32 Using Surface Electrodes to Monitor the Electric-Pulse-Induced Permeabilization of Porcine Skin / Stephen A. Gallo, Patricia G. Johnson, Sek Wen Hui 437
- 33 Transdermal Delivery Using Surface Electrodes in Porcine Skin / Patricia G. Johnson, Stephen A. Gallo, Sek Wen Hui 447
- 34 Transdermal Drug Delivery by Skin Electroporation in the Rat / Rita Vanbever, Veronique Preat 457
- 35 In Vivo Skin-Targeted Gene Delivery by Pulsed Electric Fields / Lei Zhang 473.
- Notes:
- Includes bibliographical references and index.
- ISBN:
- 0896036065
- OCLC:
- 41273245
The Penn Libraries is committed to describing library materials using current, accurate, and responsible language. If you discover outdated or inaccurate language, please fill out this feedback form to report it and suggest alternative language.