Gene transcription : mechanisms and control / Robert J. White.

Format:

Book

Author/Creator:

White, Robert J., 1963-

Language:

English

Subjects (All):

Genetic transcription.

Genetic transcription--Regulation.

Transcription, Genetic.

Medical Subjects:

Transcription, Genetic.

Physical Description:

xii, 273 pages : illustrations (some color) ; 25 cm

Place of Publication:

Malden, MA : Blackwell Science, 2001.

Summary:

Transcription is an essential process required for abstract genetic information to become physical reality. The established link between defects in gene transcription and many human disorders has fuelled considerable activity in the biomedical arena, particularly in cancer research. This concentration of attention has uncovered a myriad of factors involved in transcription and the literature is now rife with jargon and complexity.

Gene Transcription: Mechanisms and Control aims to demystify the subject for a non-expert audience, providing a guided tour around the complex machinery of the transcriptional apparatus and discussing how the various factors achieve their functions. By focusing on general principles and illustrating these with a select group of examples, many of which are linked to human diseases, the author conveys the intricacies of transcriptional control in an accessible manner.

With the first chapter presenting an overview of gene expression, this is a 'stand-alone' text, ideal for advanced level undergraduates and postgraduates in biology, biochemistry and the medical sciences. It will also appeal to research scientists who require a broad current perspective on this rapidly moving and complex field.

Contents:

2 The Nuclear RNA Polymerases 17

3 DNA Recognition by Transcription Factors 25

4 Basal Transcription by RNA Polymerase II 50

5 Activating RNA Polymerase II Transcription 72

6 Transcription by RNA Polymerase I 102

7 Transcription by RNA Polymerase III 113

8 The Influence of Chromation on Transcription 130

9 Controlling Transcription Factor Production 169

10 Regulation of Transcription Factor Localization 181

11 Regulation of Transcription Factor Activity 200

12 Cell Cycle Regulation of Transcription 224

13 Interactions Between Transcription and Other Nuclear Processes 242

14 Transcription Factors and Development 255.

Notes:

Includes bibliograhical references and index.

ISBN:

0632048883

OCLC:

44110392