Mechanisms of protein folding / edited by Roger H. Pain.

Format:

Book

Contributor:

Pain, Roger H.

Series:

Frontiers in molecular biology ; 32.

Frontiers in molecular biology ; 32

Language:

English

Subjects (All):

Protein folding.

Protein Folding.

Medical Subjects:

Protein Folding.

Physical Description:

xxvi, 433 pages, 16 unnumbered pages of color plates : illustrations ; 25 cm.

Edition:

Second edition.

Place of Publication:

Oxford ; New York : Oxford University Press, 2000.

Summary:

The process by which newly synthesized polypeptide chains become their final 3-dimensional protein forms is clearly explained, providing students and researchers of various backgrounds with both a conceptual and technical understanding of the subject. The new Second Edition incorporates the significant improvements in the field such as advances in interpreting observed kinetic data, the development of technology to observe fast folding reactions, the molten globule state, and the vital role of chaperone proteins in protein folding. The emphasis on experimental approaches has been maintained but this edition does so within the explicit context of simulations and energy surfaces. New discoveries of the central importance of protein folding and unfolding reactions in biology and medicine (including mutation and 'misfolding') are carefully explored. Three case studies elucidate the difficulties of studying protein folding in vivo.

Notes:

Includes bibliographical references and index.

ISBN:

0199637881

019963789X

OCLC:

44627036