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Scientific frontiers in developmental toxicology and risk assessment / Committee on Developmental Toxicology, Board on Environmental Studies and Toxicology, Commission on Life Sciences, National Research Council.
Holman Biotech Commons RA1224.45 .S395 2000
Available
- Format:
- Book
- Language:
- English
- Subjects (All):
- Developmental toxicology.
- Health risk assessment.
- Abnormalities--embryology.
- Toxicology.
- Developmental Biology.
- Risk Assessment.
- Medical Subjects:
- Abnormalities--embryology.
- Toxicology.
- Developmental Biology.
- Risk Assessment.
- Physical Description:
- xviii, 327 pages : illustrations ; 24 cm
- Other Title:
- Developmental toxicology and risk assessment
- Place of Publication:
- Washington, DC : National Academy Press, [2000]
- Contents:
- Recent Advances in Developmental Biology and the Promise of Genomics 13
- Committee's Approach to Its Charge 15
- Organization of the Report 15
- 2 Developmental Defects and Their Causes 17
- Toxicant Exposure and Developmental Defects 20
- The Chemical Universe 22
- 3 Current Practices for Assessing Risk for Developmental Defects and Their Limitations 26
- The Developmental Toxicity Risk Assessment Process 26
- Biomarkers 49
- Limitations in Developmental Toxicity Risk Assessments 54
- 4 Mechanisms of Developmental Toxicity 58
- History of Developmental Toxicology: Growth of a New Field 58
- Principles of Teratology 60
- Mechanisms of Toxicity 63
- 5 Human Genetics and the Human Genome Project 88
- Genotype, Phenotype, and Multifactorial Inheritance 89
- Polymorphisms 90
- The Human Genome Project 92
- Recent Developments in Molecular Epidemiology 100
- 6 Recent Advances in Developmental Biology 108
- A Brief History of Developmental Biology 108
- Advances in Developmental Biology 111
- 7 Using Model Animals to Assess and Understand Developmental Toxicity 151
- Model Organisms and the Genetic Approach 151
- The Major Model Animals for Genetic Analysis 158
- Possible Applications of Model Animal Research to Developmental Toxicology 176
- Gene Expression as Determined by In Vitro and Engineered Cell Technologies 191
- 8 A Multilevel Approach to Improving Risk Assessment for Developmental Toxicity 196
- The Multidisciplinary, Multilevel, Interactive Approach 197
- Conclusions in Relation to the Charge 200
- Recommendations 226
- Appendix B Database Descriptions 290
- Appendix C Signaling Pathways 296
- Appendix D Biographical Information on the Committee on Developmental Toxicology 309.
- Notes:
- "This project was supported by the U.S. Department of Defense; (DAMD 17-89-C9086 and DAMD 17-99-C9049), the U.S. Department of Health and Human Services; (PR-470644, PR-470645, 273-MH-901198, 273-MH-913119, P-0158-00-6-00, 0009554547, and 263-MD-635973), the U.S. Environmental Protection Agency; (CR-823615, R-827241-01), the U.S. Department of Veterans Affairs; (V101 P-1578), and the American Industrial Health Council.
- Includes bibliographical references (pages 245-277) and index.
- ISBN:
- 0309070864
- OCLC:
- 45671505
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