Genomic regulatory systems : development and evolution / Eric H. Davidson.

Format:

Book

Author/Creator:

Davidson, Eric H., 1937-2015.

Language:

English

Subjects (All):

Genomes.

Genetic regulation.

Gene expression.

Cell differentiation.

Genome.

Gene Expression Regulation.

Cell Differentiation.

Medical Subjects:

Genome.

Gene Expression Regulation.

Cell Differentiation.

Physical Description:

xii, 261 pages : color illustrations ; 24 cm

Place of Publication:

San Diego, Calif. : Academic Press, [2001]

Summary:

Authoritative, but easy-to-read book presenting the biological processes during development (and their regulation) within the framework of evolution. This text also takes an in-depth look at how the hardwired control systems of the genome work and offers an explanation for evolutionary change in animal body plans.

Contents:

1. Regulatory Hardwiring: A Brief Overview of the Genomic Control Apparatus and its Causal Role in Development and Evolution

The Regulatory Apparatus Encoded in the DNA

The Genes and Gene Regulatory Components of Animal Genomes 2

Overview of Regulatory Architecture 7

Gene Regulatory Functions in Development 11

The Regulatory Demands of Development 11

Pattern Formation 13

Terminal Differentiation 16

Genomic Regulatory Sequence and the Evolution of Morphological Features 18

Regulatory Evolution, and Evolution in General 19

Bilaterian Phylogeny 20

2. Inside the cis-Regulatory Module: Control Logic, and How Regulatory Environment is Transduced into Spatial Patterns of Gene Expression

Operating Principles for cis-Regulatory Systems that Mediate Developmental Specification Events 26

Spatial Repression in cis-Regulatory specification 28

Two Very Different Examples of Similar Import 28

cis-Regulatory Design for Autonomous Modular Function 35

The Generality of Repression 41

Downstream of Specification 44

At the Beginning of Embryogenesis 46

Polyfunctional Downstream Modules 48

The "Power" of the cis-Regulatory Module 49

Diverse cis-Regulatory Outputs from a Simple Input 50

Direct Integration of Noncoincident Spatial Inputs 52

A cis-Regulatory Logic Device 54

3. Regulation of Direct Cell-Type Specification in Early Development

The Basic Package for Bilaterian Embryogenesis: Type 1 Specification Processes 64

Regulatory Mechanism in Territorial Specification of the Sea Urchin Embryo 66

The Definitive Territories of the Embryo 66

Early Transcriptional Activation of Cell Type-specific Genes 71

Initial Regulatory Processes 74

Multiple Inputs for Endomesoderm Specification 75

Regulatory Mechanisms Controlling Specification in Ascidian Embryos 81

Territorial Specification 81

Mechanisms and Pathways in Mesoderm Specification 85

Caenorhabditis elegans: The Genomic Apparatus for Endoderm Specification 92

Endoderm Specification 93

The Network of Zygotic cis-Regulatory Interactions Required for Endoderm Specification 96

Short Summary: Quality of Type 1 Regulatory Networks 101

4. The Secret of the Bilaterians: Abstract Regulatory Design in Building Adult Body Parts

The Evolutionary Significance of "Pattern Formation" 103

The First Step: Transcriptional Definition of the Domain of the Body Part 105

Morphological Pieces and Regulatory Subpatterns 110

Heart Parts 110

Forelimb and Hindlimb Buds 111

Transcriptional Domains in the Gut Endoderm 115

Patterns in the Developing Hindbrain 117

Appendage Parts and Transcriptional Patterns in Drosophila Imaginal Discs 121

Glimpses of How It Works 122

Transcriptional Domains and the Pattern Program for the Drosophila Wing Disc: Modularity and cis-Regulatory Inputs 123

Patterning the Heart Progenitor Field in Drosophila 129

Encoding Hindbrain Regulatory Patterns 131

The Role of Signaling 140

The Last Routines: Calling in Differentiation Programs 146

Specification of Peripheral Nervous System Elements in the Drosophila Wing 147

Installation of Cell Type-specific Differentiation Programs in the Pituitary 152

5. Changes that Make New Forms: Gene Regulatory Systems and the Evolution of Body Plans

Some Examples: Evolutionary Cooption of Genes to New Pattern Formation Functions 158

hox Gene Functions and Cooptions of the hox Cluster Patterning System 164

A Specific Case of A/P Patterning: How a hox Gene Does Its Job 166

Evolutionary Changes in hox Gene Expression in the Arthropods 167

Off the A/P Axis 174

Colinear Expression of hox Genes in the Somatocoels of Sea Urchin Larvae 178

Small Changes 183

Evolutionary Origins of Body Parts 188

Polarity in Body Part Evolution 188

The Case of pax6 and Some Other Amazing Examples 191

Concluding Comment: Conceiving Evolution as a Process of Change in Regulatory Gene Networks 201.

Notes:

Includes bibliographical references (pages 203-244) and index.

ISBN:

0122053516

OCLC:

45748430