Molecular mimicry, microbes, and autoimmunity / edited by Madeleine W. Cunningham, Robert S. Fujinami.

Format:

Book

Contributor:

Cunningham, Madeleine W.

Fujinami, Robert S.

Language:

English

Subjects (All):

Autoimmune diseases--Etiology.

Autoimmune diseases.

Viral antigens.

Communicable diseases--Complications.

Communicable diseases.

Antigenic determinants.

Immunospecificity.

Autoimmunity.

Molecular Mimicry.

Antigens, Viral.

Autoimmune Diseases--etiology.

Communicable Diseases--complications.

Medical Subjects:

Autoimmunity.

Molecular Mimicry.

Antigens, Viral.

Autoimmune Diseases--etiology.

Communicable Diseases--complications.

Physical Description:

xvii, 287 pages : illustrations (some color) ; 26 cm

Place of Publication:

Washington, D.C. : ASM Press, [2000]

Contents:

1. An Overview: Molecular Mimicry and Disease / Kumar Visvanathan, John B. Zabriskie 1

2. Principles of Molecular Mimicry and Autoimmune Disease / Irun R. Cohen 17

3. Molecular Mimicry and Central Nervous System Autoimmune Disease / Robert S. Fujinami 27

4. Molecular Mimicry between Streptococcal M Protein and Cardiac Myosin and the Immunopathogenesis of Rheumatic Fever / Madeleine W. Cunningham 39

5. Antigenic Mimicry between Self and Coxsackievirus Proteins Leads to Both Humoral and Cellular Autoimmunity to Heart Proteins / Sally A. Huber, Charles J. Gauntt 57

6. Molecular Mimicry and Heart Disease / Josef M. Penninger, Kurt Bachmaier 69

7. Peptide Mimicry of Streptococcal Group A Carbohydrate / Neil S. Greenspan, Clemencia Pinilla, Alexander R. Shikhman 83

8. Role of Superantigens in Molecular Mimicry and Autoimmunity / Malak Kotb 95

9. Peptide Induction of Systemic Lupus Autoimmunity / John B. Harley, R. Hal Scofield, Judith A. James 109

10. Mimicry between DNA, Carbohydrates, and Peptides: Implications in Systemic Lupus Erythematosus / Czeslawa Kowal, Betty Diamond 127

11. Peptide Mimicry of the Polysaccharide Capsule of Cryptococcus neoformans / David O. Beenhouwer, Philippe Valadon, Rena May, Matthew D. Scharff 143

12. Autoimmunity in Lyme Arthritis: Molecular Mimicry between OspA and LFA-1 / Dawn M. Gross, Brigitte T. Huber 161

13. Exploiting Molecular Mimicry in Targeting Carbohydrate Antigens / Gina Cunto-Amesty, Thomas Kieber-Emmons 175

14. Structural Basis of T-Cell Receptor Specificity and Cross-Reactivity: Implications for the Pathogenesis of Human Autoimmune Diseases / Heiner Appel, Kai W. Wucherpfennig 197

15. Molecular Mimicry and Determinant Spreading / Anthony Quinn, Eli E. Sercarz 215

16. Molecular Mimicry: Lessons from Experimental Models of Systemic Lupus Erythematosus and Antiphospholipid Syndrome / Miri Blank, Ilan Krause, Yehuda Shoenfeld 223

17. Contributions of Viruses and Immunity as causes of Diabetes and Development of Strategies for Treatment and Prevention of Autoimmune Disease / Matthias G. von Herrath 235

18. Molecular Mimicry and Chagas' Disease / Edecio Cunha-Neto, Jorge Kalil 257.

Notes:

Includes bibliographical references and index.

ISBN:

1555811949

OCLC:

44110490