Asthma and respiratory infections / edited by David P. Skoner.

Format:

Book

Contributor:

Skoner, David P.

Series:

Lung biology in health and disease ; v.154.

Lung biology in health and disease ; v.154

Language:

English

Subjects (All):

Asthma--Etiology.

Asthma.

Respiratory infections--Complications.

Respiratory infections.

Virus diseases.

Asthma--etiology.

Respiratory Tract Infections--complications.

Virus Diseases.

Medical Subjects:

Asthma--etiology.

Respiratory Tract Infections--complications.

Virus Diseases.

Physical Description:

xv, 312 pages : illustrations ; 24 cm.

Place of Publication:

New York : Marcel Dekker, [2001]

Contents:

Part 1 Epidemiology

1. The Impact of Respiratory Virus Infections on the World's Children / Floyd W. Denny, Jr. 1

II. Classification of Acute Respiratory Infections 2

III. Etiology of Acute Respiratory Tract Infections 3

IV. Role of Respiratory Viruses and Bacteria as Causes of Acute Respiratory Infections 7

V. Role of Various Risk Factors in the Occurrence of Acute Respiratory Infections 13

VI. Role of Acute Respiratory Infections in Developing Countries 15

2. Respiratory Viruses and Asthma: Epidemiological Considerations in Evaluating Their Association / Theodore J. Witek, Jr. 23

II. Respiratory Viruses Associated with Asthma 24

III. Basic Observations 27

IV. Host and Environmental Factors 37

3. Rates of Asthma Exacerbations During Viral Respiratory Infection / Jonathan M. Corne, Sebastian L. Johnston, Richard Beasley 45

I. Early Case Reports 45

II. Indirect Evidence

Time-Series Studies 46

III. Studies in Adults 48

IV. Cross-Sectional Studies in Children 48

V. Hospital-Based Incidental Studies in Children 51

VI. Hospital-Based Incidental Studies in Adults 52

VII. Cohort Studies in Children 52

VIII. Cohort Studies in Adults 55

IX. Studies Utilizing PCR

Children 56

X. Studies Utilizing PCR

Adults 58

4. Risk Factors for Wheezing with Viral Upper Respiratory Tract Infections in Children / Michael Kabesch, Erika von Mutius 63

II. Wheezing in Infancy and Childhood 64

III. Incidence and Type of Viral Infections in Wheezing Lower Respiratory Tract Illnesses 66

IV. Risk Factors for Wheeze with Viral Respiratory Tract Infections 67

Part 2 Pathophysiology and Mechanisms

5. Mechanisms of Virus-Induced Asthma / Richard G. Hegele, James C. Hogg 89

II. Overview of Viral Infections 89

III. The Effects of Acute Viral Infections on the Airways 92

IV. Latent Viral Infections 96

V. Persistent Viral Infections 98

6. The Use of Experimentally Infected Volunteers in Research on the Common Cold / Jack M. Gwaltney, Jr. 103

II. History 103

III. Methodology 106

IV. Applications of the Rhinovirus Challenge Model 110

V. Performance of the Rhinovirus Challenge Model 114

VI. Advantage and Disadvantage of Experimental Colds in Research 120

7. Overview of Experimental Animal Respiratory Viral Provocation Models / Gert Folkerts, Henk J. Van der Linde, Frans P. Nijkamp 129

II. Airway Hyperresponsiveness to Histamine and Histamine Release 130

III. Parasympathetic Nerves 132

IV. Nonadrenergic Noncholinergic Nerves 135

V. [beta subscript 2]-Receptors 139

VI. Epithelial Damage and Dysfunction 139

8. Role of Allergy and Airway Hyperresponsiveness in Virus-Induced Asthma / James E. Gern, Robert F. Lemanske, Jr., William W. Busse 155

I. Epidemiology of Viral Infections and Asthma 155

II. Interactions Between Viruses and Allergy 157

III. Possible Mechanisms for Interaction of Viral Infection and Allergy 166

9. Limitations of Human Experimental Provocation Models for Investigating the Virus

Asthma Link / Deborah A. Gentile, David P. Skoner 183

II. Severity of Infection 186

III. Inoculation Methodologies 186

IV. Viral Characteristics 187

V. Subject Characteristics 188

VI. Environmental Factors 188

VII. Assessment of Outcomes 189

10. Stress, Viral Respiratory Infections, and Asthma / Sheldon Cohen, Mario Rodriguez 193

II. What Is Stress? 194

III. How Could Stress Affect Asthma? 196

Part 3 Current and Future Treatments

11. General Virology and Targets for Therapy / David Tyrrell 209

II. Virus Diagnosis 211

III. Prevention or Treatment of Virus Infection 214

IV. Further Prospects 218

12. Advances in the Diagnosis of Respiratory Virus Infections / A. J. Chauhan, Sebastian L. Johnston 221

II. Specimens 222

III. Detection of Virus by Electron Microscopy 223

IV. Detection of Virus by Cell Culture 223

V. Additional Test for Cell Culture (Rapid Culture Assays) 224

VI. Detection of Viral Antigen 225

VII. Detection of Viral Nucleic Acids 226

13. Current Modalities for Treatment of Respiratory Viruses and Virus-Induced Asthma / Elliot F. Ellis 245

I. Chemotherapy of Rhinovirus Infection 246

II. Chemotherapy of Coronaviruses 248

III. Chemotherapy of Influenza A 248

IV. Chemotherapy of Paramyxoviruses (RSV and Parainfluenza) 250

V. Prevention/Treatment of Virus-Induced Asthma 252

VI. Note Added in Proof 254

14. Previously Conducted Trials to Evaluate New Avenues of Therapy / Robert L. Atmar, Ronald B. Turner 259

I. Experimental Models for the Study of Viral Respiratory Pathogens 259

II. Rhinoviruses 261

III. Coronavirus Infections 265.

Notes:

Includes bibliographical references and indexes.

ISBN:

0824777107

OCLC:

45162125