The molecular basis of dementia / edited by John H. Growdon ... [and others].

Format:

Book

Contributor:

Growdon, John H. (John Herbert)

International Study Group on the Pharmacology of Memory Disorders Associated with Aging 2000 : Zurich, Switzerland)

Series:

Annals of the New York Academy of Sciences ; v. 920.

Annals of the New York Academy of Sciences ; v. 920

Language:

English

Subjects (All):

Dementia--Molecular aspects.

Dementia.

Dementia--etiology.

Medical Subjects:

Dementia--etiology.

Physical Description:

xii, 339 pages : illustrations ; 24 cm.

Place of Publication:

New York : New York Academy of Sciences, 2000.

Contents:

Part I. [alpha]-Synuclein in Neurodegenerative Disease

Clinical Lewy Body Syndromes / I.G. McKeith 1

Clinical and Neuropathological Correlates of Dementia with Lewy Bodies / E. Gomez-Tortosa, M.C. Irizarry, T. Gomez-Isla, B.T. Hyman 9

The [alpha]-Synucleinopathies: Parkinson's Disease, Dementia with Lewy Bodies, and Multiple System Atrophy / Maria Grazia Spillantini, Michel Goedert 16

Genetics of Parkinson's Disease / Mihael H. Polymeropoulos 28

Physiology and Pathophysiology of [alpha]-Synuclein: Cell Culture and Transgenic Animal Models Based on a Parkinson's Disease-associated Protein / Philipp J. Kahle, Manuela Neumann, Laurence Ozmen, Christian Haass 33

Accelerated Oligomerization by Parkinson's Disease Linked [alpha]-Synuclein Mutants / K.A. Conway, S.-J. Lee, J.-C. Rochet, T.T. Ding, J.D. Harper, R.E. Williamson, P.T. Lansbury, Jr. 42

Part II. Novel Mutations in Dementia

Classification and Description of Frontotemporal Dementias / D. Neary, J.S. Snowden, D.M.A. Mann 46

Progress in Hereditary Tauopathies: A Mutation in the Tau Gene (G389R) Causes a Pick Disease-like Syndrome / Bernardino Ghetti, Jill R. Murrell, Paolo Zolo, Maria Grazia Spillantini, Michel Goedert 52

Molecular Genetics of Chromosome 17 Tauopathies / Michael Hutton

Tau Gene Mutations in Frontotemporal Dementia and Parkinsonism Linked to Chromosome 17 (FTDP-17): Their Relevance for Understanding the Neurodegenerative Process / Michel Goedert, Bernardino Ghetti, Maria Grazia Spillantini 74

Amyloidogenesis in Familial British Dementia Is Associated with a Genetic Defect on Chromosome 13 / J. Ghiso, R. Vidal, A. Rostagno, L. Miravalle, J.L. Holton, S. Mead, T. Revesz, G. Plant, B. Frangione 84

Familial British Dementia: Expression and Metabolism of BRI / Seong-Hun Kim, Rong Wang, David J. Gordon, Joseph Bass, Donald F. Steiner, Gopal Thinakaran, David G. Lynn, Stephen C. Meredith, Sangram S. Sisodia 93

High Frequency of Mutations in Four Different Disease Genes in Early-Onset Dementia / Ulrich Finckh, Tomas Muller-Thomsen, Ulrike Mann, Christian Eggers, Josef Marksteiner, Wolfgang Meins, Giuliano Binetti, Antonella Alberici, Peter Sonderegger, Christoph Hock, Roger M. Nitsch, Andreas Gal 100

Pathological Tau Phenotypes: The Weight of Mutations, Polymorphisms, and Differential Neuronal Vulnerabilities / Christel Mailliot, Thierry Bussiere, Malika Hamdane, Nicolas Sergeant, Marie-Laure Caillet, Andre Delacourte, Luc Buee 107

Coexistent Tau and Amyloid Pathology in Hereditary Frontotemporal Dementia with Tau Mutations / S.M. Rosso, W. Kamphorst, R. Ravid, J.C. Van Swieten 115

The Clinical Spectrum of Guam ALS and Parkinson-Dementia Complex: 1997-1999 / Douglas Galasko, David Salmon, Ulla-Katrina Craig, Wigbert Wiederholt 120

Part III. Transgenic and Knockout Approaches to Neurodegenerative Diseases

In Vivo Analysis of Wild-type and FTDP-17 Tau Transgenic Mice / J. Gotz, R. Barmettler, A. Ferrari, M. Goedert, A. Probst, R.M. Nitsch 126

Pathogenic Mechanisms of Alzheimer's Disease Analyzed in the APP23 Transgenic Mouse Model / Christine Sturchler-Pierrat, Matthias Staufenbiel 134

Prions: Pathogenesis and Reverse Genetics / Adriano Aguzzi, Michael A. Klein, Fabio Montrasio, Vladimir Pekarik, Sebastian Brandner, Hisako Furukawa, Pascal Kaser, Christiane Rockl, Markus Glatzel 140

Presenilin Function in APP Processing / Wim Annaert, Philippe Cupers, Paul Saftig, Bart de Strooper 158

Role of Presenilin-1 in Murine Neural Development / Xudong Yang, Melissa Handler, Jie Shen 165

Modulation of A[beta] Deposition in APP Transgenic Mice by an Apolipoprotein E Null Background / M.C. Irizarry, G.W. Rebeck, B. Cheung, K. Bales, S.M. Paul, D. Holzman, B.T. Hyman 171

The Value of Transgenic Models for the Study of Neurodegenerative Diseases / Donald L. Price, Philip C. Wong, Alicja L. Markowska, Michael K. Lee, Gopal Thinakaren, Donald W. Cleveland, Sangram S. Sisodia, David R. Borchelt 179

Part IV. Proteases in Alzheimer's Disease

Identifying Proteases That Cleave APP / Martin Citron 192

Toward the Characterization and Identification of [gamma]-Secretases Using Transition-state Analogue Inhibitor / Chad L. Moore, Thekla S. Diehl, Dennis J. Selkoe, Michael S. Wolfe 197

Recent Advances in the Understanding of the Processing of APP to Beta Amyloid Peptide / S. Sinha, J. Anderson, V. John, L. McConlogue, G. Basi, E. Thorsett, D. Schenk 206

Presenilin-1: A Component of Synaptic and Endothelial Adherens Junctions / Anastasios Georgakopoulos, Philippe Marambaud, Victor L. Friedrich, Jr., Junichi Shioi, Spiros Efthimiopoulos, Nikolaos K. Robakis 209

[alpha]-Secretase Activity of the Disintegrin Metalloprotease ADAM 10: Influences of Domain Structure / Falk Fahrenholz, Sandra Gilbert, Elzbieta Kojro, Sven Lammich, Rolf Postina 215

Rapid Notchl Nuclear Translocation after Ligand Binding Depends on Presenilin-associated [gamma]-Secretase Activity / Oksana Berezovska, Christine Jack, Pamela McLean, Jon C. Aster, Carol Hicks, Weiming Xia, Michael S. Wolfe, Gerry Weinmaster, Dennis J. Selkoe, Bradley T. Hyman 223

GSK3[beta] Forms a Tetrameric Complex with Endogenous PS1-CTF/NTF and [beta]-Catenin: Effects of the D257/D385A and FAD-linked Mutations / G. Tesco, R.E. Tanzi 227

An Empirical Model of [gamma]-Secretase Activity / M.P. Murphy, R. Wang, P.E. Fraser, A. Fauq, T.E. Golde 233

Overexpression of Presenilin-2 Enhances Apoptotic Death of Cultured Cortical Neurons / W. Araki, K. Yuasa, S. Takeda, K. Shirotani, K. Takahashi, T. Tabira 241

[alpha]1-Antichymotrypsin Inhibits A[beta] Degradation in Vitro and in Vivo / Carmela R. Abraham, Walker T. McGraw, Franchot Slot, Rina Yamin 245

Activated Mitogenic Signaling Induces a Process of Dedifferentiation in Alzheimer's Disease That Eventually Results in Cell Death / Thomas Arendt, Max Holzer, Andrea Stobe, Ulrich Gartner, Hans-Joachim Luth, Martina K. Bruckner, Uwe Ueberham 249

Inhibition of the Neuronal Insulin Receptor: An in Vivo Model for Sporadic Alzheimer Disease? / Siegfried Hoyer, Sae Kyung Lee, Thomas Loffler, Reinhard Schliebs 256

Cytoplasmic Presenilin Aggregates in Proteasome Inhibitor-treated Cells / L.A. MacKenzie Ingano, K.M. Lentini, I. Kovacs, R.E. Tanzi, D.M. Kovacs 259

Part V. Therapies for Alzheimer's Disease beyond AChE Inhibitors

Regulation of APP Synthesis and Secretion by Neuroimmunophilin Ligands and Cyclooxygenase Inhibitors / Robert K.K. Lee, Richard J. Wurtman 261

A[beta] Modulation: The Next Generation of AD Therapeutics / Kevin M. Felsenstein 269

Prevention and Reduction of AD-type Pathology in DPAPP Mice Immunized with A[beta subscript 1-42] / Dora Games, Frederique Bard, Henry Grajeda, Terry Guido, Karen Khan, Ferdie Soriano, Nicki Vasquez, Nancy Wehner, Kelly Johnson-Wood, Ted Yednock, Peter Seubert, Dale Schenk 274

Treatment with the Selective Muscarinic Agonist Talsaclidine Decreases Cerebrospinal Fluid Levels of Total Amyloid [beta]-Peptide in Patients with Alzheimer's Disease / C. Hock, A. Maddalena, I. Heuser, D. Naber, W. Oertel, H. Von der Kammer, M. Wienrich, A. Raschig, M. Deng, J.H. Growdon, R.M. Nitsch 285

Metal Chelation as a Potential Therapy for Alzheimer's Disease / Math P. Cuajungco, Kyle Y. Faget, Xudong Huang, Rudolph E. Tanzi, Ashley I. Bush 292

Regulation of Gene Expression by Muscarinic Acetylcholine Receptors: A Comprehensive Approach for the Identification of Regulated Genes / Heinz von der Kammer, Manuel Mayhaus, Claudia Albrecht, Barbara Andresen, Jaroslav Klaudiny, Cuneyt Demiralay, Roger M. Nitsch 305

Cholinergic Modulation of Amyloid Processing and Dementia in Animal Models of Alzheimer's Disease / O. Isacson, L. Lin 309

M1 Muscarinic Agonists as Potential Disease-Modifying Agents in Alzheimer's Disease: Rationale and Perspectives / A. Fisher, D.M. Michaelson, R. Brandeis, R. Haring, S. Chapman, Z. Pittel 315

Cholinesterase Inhibitors Stabilize Alzheimer's Disease / Ezio Giacobini 321

Nasal A[beta] Treatment Induces Anti-A[beta] Antibody Production and Decreases Cerebral Amyloid Burden in PD-APP Mice / C.A. Lemere, R. Maron, E.T. Spooner, T.J. Grenfell, C. Mori, R. Desai, W.W. Hancock, H.L. Weiner, D.J.

Selkoe 328

Cytidine (5')Diphosphocholine Modulates Dopamine K[superscript +]-evoked Release in Striatum Measured by Microdialysis / J. Agut, J.A. Ortiz, R.J. Wurtman 332.

Notes:

"These papers were presented at the ninth meeting of the International Study Group on the Pharmacology of Memory Disorders Associated with Aging, held on February 18-20, 2000 in Zurich, Switzerland"--Contents p.

Includes bibliographical references and index.

ISBN:

1573312835

1573312843

OCLC:

45066040