Part I. VIP/PACAP Receptors: Diagnostic and Therapeutic Implications, with Special Reference to Malignant Disease
In Vitro Evaluation of VIP/PACAP Receptors in Healthy and Diseased Human Tissues: Clinical Implications / Jean Claude Reubi 1
VPAC[subscript 1] Receptors and Lung Cancer / T.W. Moody, J. Walters, M. Casibang, F. Zia, Y. Gozes 26
Downregulation of VPAC[subscript 1]R Expression in Breast Cancer Cell Lines / Bente Madsen, Birgitte Georg, Mogens W. Madsen, Jan Fahrenkrug 33
Imaging Tumors in Humans with Tc-99m-VIP / M.L. Thakur, C.S. Marcus, S. Saeed, V. Pallela, C. Minami, L. Diggles, H.L. Pham, R. Ahdoot, E.A. Kalinowski, T. Moody 37
Part II. Neuroimmunology and Inflammation
Vasoactive Intestinal Peptide (VIP) Receptor Type 2 (VPAC[subscript 2]) is the Predominant Receptor Expressed in Human Thymocytes / Maria L. Lara-Marquez, M. Sue O'Dorisio, Bahri Karacay 45
VIP and PACAP Inhibit Activation Induced Apoptosis in T Lymphocytes / Mario Delgado, Doina Ganea 55
VIP and PCAP Induce Shift to a Th2 Response by Upregulating B7.2 Expression / Mario Delgado, Javier Leceta, Wei Sun, Rosa P. Gomariz, Doina Ganea 68
Vasoactive Intestinal Peptide Mediation of Development and Functions of T Lymphocytes / Glenn Dorsam, Julia Voice, Yvonne Kong, Edward J. Goetzl 79
Receptors and Transcriptional Factors Involved in the Anti-Inflammatory Activity of VIP and PACAP / Javier Leceta, Rosa P. Gomariz, Carmen Martinez, Catalina Abad, Doina Ganea, Mario Delgado 92
Part III. Neurodevelopment and Neuroprotection
Neuropeptide Action in Sympathetic Ganglia: Evidence for Distinct Functions in Intact and Axotomized Ganglia / Richard E. Zigmond 103
Chemokines Released from Astroglia by Vasoactive Intestinal Peptide: Mechanism of Neuroprotection from HIV Envelope Protein Toxicity / Douglas E. Brenneman, Janet Hauser, Catherine Y. Spong, Terry M. Phillips 109
A Novel VIP Responsive Gene: Activity Dependent Neuroprotective Protein / I. Gozes, R. Zamostiano, A. Pinhasov, M. Bassan, E. Giladi, R.A. Steingart, D.E. Brenneman 115
Neuroprotective Effects of PACAP38 in a Rat Model of Transient Focal Ischemia under Various Experimental Conditions / Dora Reglodi, Aniko Somogyvari-Vigh, Sandor Vigh, Jerome L. Maderdrut, Akira Arimura 119
PACAP Action in Nervous System Development, Regeneration, and Neuroblastoma Cell Proliferation / James A. Waschek, Emanuel M. Dicicco-Bloom, Vincent Lelievre, Xinrong Zhou, Zhongting Hu 129
Part IV. Receptor and Peptide Expression
Characterization of Intestinal Receptors for VIP and PACAP in Rat and in PAC[subscript 1] Receptor Knockout Mouse / E. Ekblad, H. Jongsma, P. Brabet, J. Bockaert, F. Sundler 137
Mutational Analysis of the Glucose Regulatory Element in the Promoter of the Glucagon Receptor Gene / Laurence Portois, Michele Tastenoy, Michal Svoboda 148
Molecular Characterization of the VIP Receptor Transcriptional Repressor Protein / Lin Pei 157
Regulation of Vasoactive Intestinal Peptide Receptor Expression in Developing Nervous Systems / Bahri Karacay, M. Sue O'Dorisio, Monica Summers, Jarrod Bruce 165
Part V. Signal Transduction
Differential Activation of Phospholipase D by VPAC and PAC[subscript 1] Receptors / D.A. McCulloch, E.M. Lutz, M.S. Johnson, C.J. MacKenzie, R. Mitchell 175
PACAP Modulates Rat Sympathetic Neuron Depolarization Through IP[subscript 3] / Victor May, Matthew M. Beaudet, Rodney L. Parsons, Karen M. Braas 186
Essential Structural Motif in the C-Terminus of the PACAP Type I Receptor for Signal Transduction and Internalization / Joseph R. Pisegna, Rong-Ming Lyu, Patrizia M. Germano 195
Part VI. Physiology, Interactions with Other Transmitters
PACAP Peptides Modulate Guinea Pig Cardiac Neuron Membrane Excitability and Neuropeptide Expression / Rodney L. Parsons, Todd M. Rossignol, Michelle A. Calupca, Jean C. Hardwick, Karen M. Braas 202
Functional Significance of Colocalization of PACAP and Catecholamine in Nerve Terminals / Seiji Shioda, Toshihiko Yada, Shinji Muroya, Shigeaki Uramura, Shigeo Nakajo, Hirokazu Ohtaki, Toshiko Hori, Yoshimi Shimoda, Hisayuki Funahashi 211
VIP- and PACAP-Induced Salivary Chromogranin A Secretion in the Isolated Perfused Submandibular Gland of Rats / Noboru Yanaihara, Tomio Kanno, Naoto Asada, Toshihiko Iwanaga, Li Jun, Shingo Nagasawa, Chizuko Yanaihara 218
Part VII. Glucoregulation, Appetite, and Digestive Function
New Developments in the Biology of the Glucagon-Like Peptides GLP-1 and GLP-2 / Daniel J. Drucker, Julie Lovshin, Laurie Baggio, Min Nian, Feisal Adatia, Robin P. Boushey, Yuanfang Liu, Jumana Saleh, Bernardo Yusta, Louise Scrocchi 226
Role of PACAP[subscript 1] Receptor in Regulation of ECL Cells and Gastric Acid Secretion by Pituitary Adenylate Cyclase Activating Peptide / Joseph R. Pisegna, Gordon V. Ohning, Christophe Athmann, Ningxin Zeng, John H. Walsh, George Sachs 233
Integrative Mitogenic Role of Protein Kinase B/Akt in [beta]-Cells / Katja Trumper, Andrea Trumper, Heidi Trusheim, Rudolf Arnold, Burkhard Goke, Dieter Horsch 242
The Effects of PACAP on Insulin Secretion and Glucose Disposal Are Altered by Adrenalectomy in Mice / Bo Ahren, Karin Filipsson 251
Intraperitoneal PACAP Administration Decreases Blood Glucose in GK Rats, and in Normal and High Fat Diet Mice / Toshihiko Yada, Masaya Sakurada, Karin Filipsson, Masatoshi Kikuchi, Bo Ahren 259
Part VIII. The Viktor Mutt Memorial Lecture
The Viktor Mutt Memorial Lecture: Protection by VIP and Related Peptides Against Cell Death and Tissue Injury / Sami I. Said 264
1. Diagnostic and Therapeutic Implications, with Special Reference to Malignant Disease
Cyanine Dye Labeled Vasoactive Intestinal Peptide and Somatostatin Analog for Optical Detection of Gastroenteropancreatic Tumors / Andreas Becker, Carsten Hessenius, Sarah Bhargava, Carsten Grotzinger, Kai Licha, Jens Schneider-Mergener, Bertram Wiedenmann, Wolfhard Semmler 275
Analysis of VIP and CGRP Plasma Levels After Radiotherapy for Treatment of Metastasis from Prostatic Carcinoma / S. Forsgren, F. Landstrom, U. Kjorell, R. Henriksson, L. Franzen 279
2. Neuroimmunology and Inflammation
Anti-inflammatory Actions of VIP/PACAP: Role in Endotoxemia / R. Gomariz, J. Leceta, C. Martinez, C. Abad, D. Ganea, M. Delgado 284
3. Neurodevelopment and Neuroprotection
The Effect of Cardiac Arrest on the Permeability of the Mouse Blood-Brain and Blood-Spinal Cord Barriers to PACAP / H. Mizushima, W. Banks, K. Dohi, Y. Nakamura, K. Matsumoto, S. Shioda 289
PACAP Acts as a Neurotrophic Factor During Histogenesis of the Rat Cerebellar Cortex / D. Vaudry, B.J. Gonzalez, M. Basille, T.F. Pamantung, A. Fournier, H. Vaudry 293
4. Receptor and Peptide Expression
Molecular Cloning, mRNA Distribution and Pharmacological Characterization of a VIP/PACAP Receptor in the Frog Rana ridibunda / D. Alexandre, Y. Anouar, S. Jegou, A. Fournier, H. Vaudry 300
Distribution of PACAP Receptor mRNAs and PACAP Binding Sites in the Rat Brain During Development / M. Basille, D. Vaudry, Y. Coulouarn, S. Jegou, I. Lihrmann, A. Fournier, H. Vaudry, B.J. Gonzalez 304
Immunohistochemical and Immunochemical Evidence for Expression of Human Lung PACAP/VIP Receptors / R. Busto, I. Carrero, G. Bodega, J. Zapatero, J.C. Prieto 308
Expression and Coupling of PACAP/VIP Receptors in Cortical Neurons and Type I Astrocytes / Maurizio Grimaldi, Sebastiano Cavallaro 312
Ultrastructural Localization of PACAP Immunoreactivity in the Rat Retina / Sachiko Izumi, Tamotsu Seki, Seiji Shioda, C.-J. Zhou, Akira Arimura, Ryohei Koide 317
PACAP and VIP in the Photoneuroendocrine System: From the Retina to the Pituitary Gland / K. Koves, O. Kantor, V. Vereczki, M. Kausz, A. Nemeskeri, K. Fogel, A. Kiss, T.J. Gorcs, G. Szeiffert, A.
Arimura 321
Synaptic Interaction between Galanin Immunoreactive Neurons and Axon Terminals Immunopositive for VIP and PACAP in the Bed Nucleus of the Stria Terminalis in the Rat / Tamas Kozicz, Akira Arimura 327
Prohormone Convertase PC4 Processes the Precursor of PACAP in the Testis / Min Li, Majambu Mbikay, Kazuhisa Nakayama, Atsuro Miyata, Akira Arimura 333
Presence of PACAP-Immunoreactive Neurons in the Trigeminal Ganglion of the Sheep: Indications for a Trigeminal Innervation of the Pineal Gland / W. Liu, J. Fahrenkrug, J. Hannibal, J.-P. Ravault, M. Moller 340
Genomic Organization and Chromosomal Localization of the Mouse Pituitary Adenylate Cyclase Activating Polypeptide (PACAP) Gene / Atsuro Miyata, Hirofumi Sano, Min Li, Youichi Matsuda, Hiroyuki Kaiya, Kumi Sato, Hisayuki Matsuo, Kenji Kangawa, Akira Arimura 344
PACAP Receptor Expression in the Rat Adrenal Medulla by In situ Hybridization and Immunocytochemistry / Masayo Muroi, Hisayuki Funahashi, Cheng Ji Zhou, Hirokazu Ohtaki, Akira Arimura, Seiji Shioda 349
Alanine Scanning of VIP: Structure-Function Relationship for Binding to Human Recombinant VPAC[subscript 1] Receptor / P. Nicole, C. Rouyer-Fessard, A. Couvineau, C. Drouot, P. Fulcrand, J. Martinez, M. Laburthe 352
Postnatal Development of Vasoactive Intestinal Peptide Receptor-Effector System in Rat Immunocompetent Cells / David Pozo, Juan M. Guerrero, Juan R. Calvo 357
Sequences (103-110) and (116-120) of the Rat Secretin Receptor are Implicated in Secretin and VIP Recognition / P. Robberecht, E. Di Paolo, N. Moguilevsky, A. Bollen, M. Waelbroeck 362
Gene Expression for PACAP Receptor mRNA in the Rat Retina by in Situ Hybridization and in Situ RT-PCR / Tamotsu Seki, Sachiko Izumi, Seiji Shioda, Cheng Ji Zhou, Akira Arimura, Ryohei Koide 366
Organization of the Rat PACAP Gene / Sheryl L. White, Victor May, Karen M. Braas 370
Distribution of PACAP Receptor and Its Splice Variants in the Rat Brain by in Situ RT-PCR / Cheng Ji Zhou, Sakae Kikuyama, Akira Arimura, Seiji Shioda 373
Ontogeny of PACAP Receptor and Its Splice Variants in the Rat Brain / Cheng Ji Zhou, Sakae Kikuyama, Shigeo Nakajo, Akira Arimura, Seiji Shioda 375
5. Signal Transduction
Effect of Flutamide Androgen-Receptor Blockade on Rat Prostatic VIP Receptor/Effector System / M.J. Carmena, L. Montalvo, R.M. Solano, C. Clemente, I.D. Roman, M. Sanchez-Chapado, J.C. Prieto 377
Dual Contacts between Peptide Agonist Ligands and the Secretin Receptor Directly Established by Photoaffinity Labeling / Maoqing Dong, Yan Wang, Laurence J. Miller 381
VIP Regulates Angiotensinogen Synthesis in the Liver / K.A. Duggan, V.Z.C. Ye 387
Nerve Growth Factor Upregulates the PAC[subscript 1] Promoter by Activating the MAP Kinase Pathway in Rat PC12 Cells / F. Jamen, J.C. Laden, T. Bouschet, N. Rodriguez-Henche, J. Bockaert, P. Brabet 390
Different Domains of the VIP Receptors Modulate Agonist Affinity and Intrinsic Activity / M.G. Juarranz, J. Van Rampelbergh, P. Gourlet, M. Waelbroeck, P. Robberecht 395
6. Physiology, Interactions with Other Transmitters
PAC[subscript 1] Null Females Display Decreased Fertility / F. Jamen, N. Rodriguez-Henche, F. Pralong, B. Jegou, R. Gaillard, J. Bockaert, P. Brabet 400
The Inhibitory Effect of PACAP38 on Ovulation is Mediated by CRF and Endogenous Opioids / O. Kantor, J. Molnar, A. Heinzelmann, Z. Furst, A. Arimura, K. Koves 405
PACAP and VIP Induce Changes in Cytosolic Calcium in Putative Folliculostellate Cells of the Mouse Pituitary / Petra Kunzelmann, Audrey Creff, Karl Bauer, Patrice Mollard 410
PACAP Augments Nitric Oxide Synthesis in Rat Vascular Smooth Muscle Cells Stimulated with IL-1[alpha] / Hirofumi Sano, Atsuro Miyata, Kumi Sato, Hiroyuki Kaiya, Hisayuki Matsuo, Kenji Kangawa 415
Synergistic Interaction Between VIP-Related Peptides and Bombesin on Ion Transport in Guinea Pig Distal Colonic Mucosa / Mutsuaki Suzuki, Atsukazu Kuwahara 420
The Effect of VIP on Progesterone (PROG) Release in Dehydrated Male Rats / Elzbieta Wasilewska-Dziubinska, Malgorzata Radzikowska, Boguslawa Baranowska 425
Occurrence and Effect of PACAP in the Human Fetal Adrenal Gland / Lyne Breault, Laurent Yon, Maite Montero, Lucie Chouinard, Vincent Contesse, Catherine Delarue, Alain Fournier, Jean-Guy LeHoux, Hubert Vaudry, Nicole Gallo-Payet 429
7. Glucoregulation, Appetite, and Digestive Function
Distribution of Vasoactive Intestinal Polypeptide and its Effect on Glucagon Secretion from Normal and Diabetic Pancreatic Tissue Fragments in Rat / E. Adeghate, A.S. Ponery, K. Koves 434
PACAP Activates Pancreatic [alpha]-Cells in a Glucose Independent Manner / Satoko Arahira, Masami Kusao, Seiji Shioda, Toshihiko Yada 438
The Role of VIP and Somatostatin in the Control of GH and Prolactin Release in Anorexia Nervosa and in Obesity / B. Baranowska, M. Radzikowska, E. Wasilewska-Dziubinska, K. Roguski, M. Borowiec 443
PACAP27 Sensitizes Glucose Induced Insulin Secretion in INS-1 Cells / Karin Filipsson, Bo Ahren 456
Distinctive Effects of Glicentin, GLP-1 and GLP-2 on Adaptive Response to Massive Distal Small Intestine Resection in Rats / Y. Hirotani, K. Yamamoto, C. Yanaihara, L. Balaspiri, N. Yanaihara, K. Kurokawa 460
Cytosolic Calcium Handling in Islets of Normal Wistar and Diabetic Goto Kakizaki Rats in the Presence of Glucose and Truncated Glucagon-like Peptide 1 (7-36) Amide / Jean-Claude Marie, Danielle Bailbe 464
Colocalization of GLP-1 and GIP in Human and Porcine Intestine / Kristine Mortensen, Louise Lundby Petersen, Cathrine Orskov 469
Insulinotropin PACAP Potentiates Insulin Action: Stimulation of Glucose Uptake in 3T3-LI Adipocytes / Toshihiko Yada, Masanori Nakata, Seiji Shioda 473.
Notes:
"This volume is the result of a conference entitled "Fourth International Symposium on VIP, PACAP, Glucagon, and Related Peptides, held on Sept. 2-4, 2999, in Elsinore, Denmark"--Contents p.
Includes bibliographical references and index.
ISBN:
1573312738
1573312746
OCLC:
45137527
The Penn Libraries is committed to describing library materials using current, accurate, and responsible language. If you discover outdated or inaccurate language, please fill out this feedback form to report it and suggest alternative language.
We want your feedback!
Thanks for using the Penn Libraries new search tool. We encourage you to submit feedback as we continue to improve the site.