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The neuropathology of schizophrenia : progress and interpretation / edited by Paul J. Harrison and Gareth W. Roberts.
Holman Biotech Commons RC514 .N446 2000
By Request
- Format:
- Book
- Language:
- English
- Subjects (All):
- Schizophrenia--Pathophysiology.
- Schizophrenia.
- Schizophrenia--Etiology.
- Schizophrenia--physiopathology.
- Brain--physiopathology.
- Nervous System--physiopathology.
- Schizophrenia--etiology.
- Medical Subjects:
- Schizophrenia--physiopathology.
- Brain--physiopathology.
- Nervous System--physiopathology.
- Schizophrenia--etiology.
- Physical Description:
- xii, 374 pages : illustrations ; 25 cm
- Place of Publication:
- Oxford ; New York : Oxford University Press, 2000.
- Contents:
- 1 Structural Imaging Findings and Macroscopic Pathology / Richard Hopkins, Shon Lewis 5
- In vivo brain imaging in schizophrenia 7
- Brain morphology in schizophrenia 8
- Global versus regional changes 17
- Structural abnormalities as part of a neural network 35
- Timing and progression of structural abnormalities 36
- Diagnostic specificity of the findings 38
- 2 Hippocampal Pathology / Steven E. Arnold 57
- Neuroanatomy of the normal hippocampal formation 58
- Gross morphometry of the hippocampal formation in schizophrenia 61
- Hippocampal cytoarchitecture and neuronal morphometry in schizophrenia 62
- Cognitive impairment, dementia, and investigations of neurodegeneration in schizophrenia 69
- Regional specificity of hippocampal neuropathological findings 71
- 3 Cortical Pathology: a New Generation of Quantitative Microscopic Studies / Francine M. Benes 81
- Stereomorphometric studies 82
- The cortical GABA system 86
- The cortical glutamate system 88
- The cortical dopamine system 91
- Cortical pathology and the neurodevelopmental hypothesis 94
- 4 Synaptic Pathology / William G. Honer, Clint Young, Peter Falkai 105
- Assessment of synapses 105
- Models of synaptic abnormalities in schizophrenia 114
- Studies of synapses in schizophrenia 115
- 5 Gliosis and its Implications for the Disease Process / Gareth W. Roberts, Paul J. Harrison 137
- Glia and gliosis 137
- Gliosis in schizophrenia 140
- The meaning of an absence of gliosis 143
- 6 Cerebral Asymmetry / Dorothy P. Holinger, Albert M. Galaburda, Paul J. Harrison 151
- Structural cerebral asymmetries 152
- Cerebral asymmetry in schizophrenia 155
- 7 Functional Imaging and Neural Circuitry in Schizophrenia / Susan K. Schultz, Nancy C. Andreasen 173
- Applied neuroimaging and the neuropathology of schizophrenia 173
- Functional imaging techniques 175
- Functional imaging and neurocircuitry 177
- Corticothalamocerebellar circuitry and cognitive dysmetria in schizophrenia 182
- 8 Neuropathology and the Neurodevelopmental Model / Mayada Akil, Daniel R. Weinberger 189
- Evidence supporting a neurodevelopmental origin of schizophrenia 190
- Evidence against schizophrenia as a neurodegenerative disorder 193
- Neuropathological findings and the neurodevelopmental model 195
- Limitations of the neurodevelopmental model 202
- 9 Cortical Development and Schizophrenia / Jack Price, Gareth W. Roberts 213
- Molecular basis for the organisation of the forebrain 215
- Pattern formation and its functional consequences 223
- Fate determination 227
- 10 The Organization of Cortical Circuitry / David A. Lewis 235
- A model system for circuitry analysis: the primate dorsolateral prefrontal cortex 236
- Cortical neuron types 237
- Laminar arrangement of neurons 239
- Organization of efferent projections 241
- Organization and termination of afferent projections 242
- Vulnerable prefrontal cortex circuitry in schizophrenia 245
- 11 Perspectives from other Diseases and Lesions / Margaret M. Esiri, R. Carl A. Pearson 257
- Neuropathology and diagnostic issues 257
- Diseases sharing non-specific pathological features with schizophrenia 258
- Disorders in which schizophrenia-like symptoms may occur 262
- Normal determinants of neuronal parmeters and the effects of experimental lesions 265
- 12 Animal Models of Schizophrenia / Barbara K. Lipska, Daniel R. Weinberger 277
- Modeling schizophrenia in animals: some general considerations 278
- Neurodevelopmental animal models of schizophrenia 280
- Future approaches to modeling schizophrenia in animals 285
- 13 A Sceptical View of the Neuropathology of Schizophrenia / Siew E. Chua, Peter J. McKenna 291
- Overall brain dimensions 292
- Lateral ventricular enlargement 298
- Regional cerebral volumes 304
- Temporal lobe limbic structures 310
- Other brain structures 312
- Histological findings 321
- 14 Methodological Issues / Paul J. Harrison, Joel E. Kleinman 339
- Methodological issues in case collection and selection 340
- Methodological issues for studies of neurochemical pathology 343
- Methodological issues for morphometric studies 345
- 15 Neuropathological Consequences of Schizophrenia Treatments / Paul J. Harrison 351
- Neuropathological effects of antipsychotic drugs 351
- Neuropathological effects of other treatments 361
- Neuropathological effects of substance misuse 362.
- Notes:
- Includes bibliographical references and index.
- ISBN:
- 0192629077
- OCLC:
- 43801030
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