Hematopoietic stem cell transplantation / edited by Anthony D. Ho, Rainer Haas, Richard E. Champlin.

Format:

Book

Contributor:

Ho, Anthony.

Haas, R. (Rainer), 1955-

Champlin, Richard.

Language:

English

Subjects (All):

Hematopoietic stem cells--Transplantation.

Hematopoietic stem cells.

Hematopoietic Stem Cell Transplantation.

Medical Subjects:

Hematopoietic Stem Cell Transplantation.

Physical Description:

xvi, 604 pages : illustrations ; 27 cm

Place of Publication:

New York : Marcel Dekker, 2000.

Summary:

This book integrates recent advances in molecular and cell biology of hematopoietic stem cells (HSC) with developments in clinical research in stem cell-based therapy-providing an up-to-date review of novel cytokines and cellular components; animal models; cell preparation, selection, and collection; minimal residual disease and purging; expansion of progenitor cells; allogeneic and autologous transplantation; cellular gene and immunotherapy; and more. Examines key areas for treatment with HSC, including ambulatory care and monitoring, regimen-related toxicities, immunodeficiency and immunization, infection, chronic graft-versus-host and disease, secondary malignancies, and long-term quality of life. Covering stem cell pool regulation and the complex interplay of extrinsic and intrinsic events, Hematopoietic Stem Cell Transplantation summarizes current understanding and development of clinical allogeneic HSC transplantation discusses the use of allogeneic transplantations with reduced conditioning regimen or mini-transplantation considers various strategies for mobilization of HSCs from peripheral blood (PB) of normal donors details detection of bone marrow contamination by tumor cells and removal procedures focuses on efforts to increase the ex vivo transduction efficiency of human HSCs with retroviral vectors explores the effects of growth factor administration and leukapheresis on PB stem cell donors shows the impact of CD34+ cell isolation and the relevance of expansion of HSC from bone marrow for clinical use reveals how minimal residue disease detection assays are crucial for tracking the clinical significance of infused tumor cells employs automated fluorescence image cytometry to study early HSC behavior following seeding Incorporating contributions from over 90 researchers who cite more than 2180 references to encourage continued study, Hematopoietic Stem Cell Transplantation is a blue-chip reference for hematologists, hematopathologists, oncologists, cytotherapists, transplantation immunologists, and molecular biologists.

Contents:

Novel Cytokines and Cellular Components

1. Thrombopoietin: Basic Biology and Clinical Effects / Kenneth Kaushansky, C. Glenn Begley 1

2. Preclinical Biology and Potential Clinical Utility of flt3 Ligand / Douglas E. Williams 23

3. Stem Cell Factor / Leo Lacerna, Jr., Russell Basser, C. Glenn Begley, Jeffrey Crawford, George Demetri, Craig H. Moskowitz, Guido Tricot, Andrew Weaver, William P. Sheridan, John A. Glaspy 31

4. Cytokine Modulation of Hematopoietic Stem Cell Phenotype / Ahmad-Samer Al-Homsi, Peter J. Quesenberry 47

5. Homing and Self-Renewal of Hematopoietic Stem Cells / Anthony D. Ho, Michael Punzel, Stefan Fruehauf, Shiang Huang, Bernhard Palsson 69

6. Requirements for Hematopoietic Stem Cell Engraftment and Graft Engineering: Role of Facilitating Cells / Michael Neipp, Christina L. Kaufman, Marianne Bergheim, Beate G. Exner, Suzanne T. Ildstad 87

7. Ins and Outs of Hematopoietic Stem Cells: Regulation by Genes and Stromal Cells / Christa E. Muller-Sieburg, Rajeev Soni 111

8. Cell-Signaling by Adhesion Receptors in Normal and Leukemic Hematopoiesis / Catherine M. Verfaillie, Yuehua Jiang, Robert C. H. Zhao, Felipe Prosper, Ravi Bhatia 125

9. Detection of Infrequent Cells in Blood and Bone Marrow by Flow Cytometry / Leon W. M. M. Terstappen 137

Animal Models

10. Human/Sheep Hematopoietic Chimeras / Graca Almeida-Porada, Christopher D. Porada, Nam D. Tran, Joao L. Ascensao, Esmail D. Zanjani 153

11. Canine Models for Transplantation and Gene Therapy / Hans-Peter Kiem, Rainer Storb 171

12. Murine Model of In Utero Transplantation / Ewa Carrier 195

CD34+ Selection

13. CD34 Selection Using Immunomagnetic Beads / Robert A. Preti, Andrew L. Pecora, Tauseef Ahmed, Timothy J. Farley 223

14. Autologous and Allogeneic Transplantation with Blood CD34[superscript +] Cells: A Pediatric Experience / Yoshifumi Kawano, Yoichi Takaue, Tsutomu Watanabe, Yasuhiro Okamoto, Takanori Abe, Yasuhiro Kuroda, Arata Watanabe 239

15. Using Allogeneic Graft Engineering to Improve Long-Term Survival / Stephen J. Noga 251

Purging

16. Detection and Significance of Minimal Residual Disease from Solid Tumor Malignancies in Stem Cell Autografts / Amy A. Ross 275

17. Stem Cell Isolation with Immunomagnetic Beads and Tumor Cell Contamination / Gunnar Kvalheim, Anne Pharo, Harald Holte, Elisabeth Lenschow, Mengyu Wang, Bjorn Erikstein, Stein Kvaloy, John Magne Nesland, Erlend Smeland 291

Ex Vivo Expansion

18. CD34 Cell Culture: Clinical Needs and Applications / Dennis E. Van Epps 303

19. Critical Parameters Influencing the Expansion and Differentiation of Cultured Human CD34[superscript +] Cells / Jane S. Lebkowski, Lisa R. Schain 321

Advances in Allogeneic Transplantation

20. Mobilization of Peripheral Blood Stem Cells from Normal Donors / Thomas A. Lane, Ping Law 333

21. Innovative Approaches for Allogeneic Blood and Marrow Transplantation for Treatment of Hematological Malignancies: Graft Engineering and Nonmyeloablative Preparative Regimens / Richard E. Champlin 361

22. Peripheral Blood Stem Cells for Allogeneic Transplantation / Lutz Uharek, Peter Dreger, Bertram Glass, Matthias Zeis, Norbert Schmitz 383

23. Mechanisms of Cure of Acute Myeloid Leukemia with Allogeneic Transplantation / Frederick R. Appelbaum 403

24. Late Complications of Hematopoietic Stem Cell Transplantation / Emin Kansu, Keith M. Sullivan 413

GVHD, GVL

25. Prevention of Acute Graft-Versus-Host Disease by Delayed or Selected Lymphocyte Add Back / John Barrett, Dimitrios Mavroudis 435

Advances in Autologous Transplantation

26. Blood Stem Cell Versus Bone Marrow Transplantation: A Critical Appraisal / Anne Kessinger 447

27. Autologous Peripheral Blood Stem Cell Collection and Engraftment / Stefan Hohaus, Maria Teresa Voso, Simona Martin, Rainer Haas 457

28. Stem Cell Transplantation for Hodgkin's Disease / Ram Kancherla, Tauseef Ahmed 479

29. Stem Cell Transplantation for Multiple Myeloma

10 Years Later / David S. Siegel, Seah H. Lim, Guido Tricot, K. R. Desikan, A. Fassas, Jayesh Mehta, Seema Singhal, Elias Anaissie, Sundar Jagannath, Barthel Barlogie 499

30. High-Dose Therapy for Primary and Metastatic Breast Cancer / Gary Spitzer, Kenneth Meehan, Douglas Adkins 517

Genetic and Immune Therapy

31. Gene Therapy Using Hematopoietic Stem Cells / Donald B. Kohn, Gay M. Crooks, Jan A. Nolta 537

32. Gene Therapy for Human Immunodeficiency Virus Infection Using Stem Cell Transplantation / Alain Gervaix, Flossie Wong-Staal 553

33. Autografting Followed by Low-Intensity Conditioning Regimen for Allografting / Angelo M. Carella 569

34. Development of Retroviral Vectors that Target Hematopoietic Stem Cells / Chris A. Benedict, Yi Zhao, Nori Kasahara, Paula M. Cannon, W. French Anderson 575.

Notes:

Includes bibliographical references and index.

OCLC:

43992464