Endocrine oncology / edited by Stephen P. Ethier.

Format:

Book

Contributor:

Ethier, Stephen P.

Series:

Contemporary endocrinology (Totowa, N.J.)

Contemporary endocrinology

Language:

English

Subjects (All):

Endocrine glands--Cancer.

Endocrine glands.

Endocrine glands--Tumors.

Cancer--Endocrine aspects.

Cancer.

Breast Neoplasms--physiopathology.

Endocrine Gland Neoplasms--physiopathology.

Prostatic Neoplasms--physiopathology.

Medical Subjects:

Breast Neoplasms--physiopathology.

Endocrine Gland Neoplasms--physiopathology.

Prostatic Neoplasms--physiopathology.

Physical Description:

xi, 395 pages : illustrations (some color) ; 26 cm.

Place of Publication:

Totowa, N.J. : Humana Press, 2000.

Summary:

Endocrine Oncology provides a comprehensive overview of the issues and controversies surrounding the role of steroid- and peptide hormones, and their receptors, in the biology of neoplasms of endocrine target tissues such as breast, prostate, uterus, and ovary.

An extensive section on breast cancer contains chapters that describe the endocrinology of normal and neoplastic breast from the perspectives of tumor development, therapy and prevention. The next sections deal with ovarian cancer, endometrial cancer, and prostate cancer. The last section is devoted to a presentation of what is known about the role of peptide growth factors, their receptors and binding proteins in endocrine neoplasia. Endocrine Oncology lays the groundwork for the understanding of biologically based therapies of endocrine cancers and will be useful to oncologists, endocrinologists, surgeons, and basic and clinical scientists studying these endocrine cancers.

Contents:

1 Estrogen Receptor in Mammary Gland Physiology / Elizabeth Anderson, Robert B. Clarke, Anthony Howell 1

2 Multiple Facets of Estrogen Recptor in Human Breast Cancer / Leigh C. Murphy, Etienne Leygue, Helmut Dotzlaw, Amanda Coutts, Biao Lu, Aihua Huang, Peter H. Watson 17

3 Progresterone Receptors in Normal and Neoplastic Breast / Rosemary L. Balleine, Patricia A. Mote, Sybille M. N. Hunt, Eileen M. McGowan, Christine L. Clarke 35

4 Pathogenesis of Estrogen Receptor-Positive and -Negative Breast Cancer / Powel Brown, Suzanne Fuqua, Craig Allred 49

5 Regulation of EGFR and ERBB2 Expression by Estrogen Receptor in Breast Cancer / Helen C. Hurst 69

6 Tamoxifen and Other Antiestrogens in Prevention and Therapy of Breast Cancer / Kathy Yao, V. Craig Jordan 79

7 Prolactin in Human Breast Cancer Development / Barbara K. Vonderhaar 101

8 Human Chorionic Gonadotropin in Breast Cancer Prevention / Jose Russo, I. H. Russo 121

9 Epidermal Growth Factor-Related Peptides in Endocrine Neoplasias / David S. Salomon, Caterina Bianco, Marta De Santis, Isabel Martinez-Lacaci, Christian Wechselberger, Andreas D. Ebert 137

10 Insulin-Like Growth Factors and Endocrine Neoplasia / Douglas Yee, Adrian V. Lee 193

11 Insulin-Like Growth Factor Binding Proteins in Endocrine-Related Neoplasia / Giuseppe Minniti, Youngman Oh 215

12 Fibroblast Growth Factors and Their Receptors in Breast and Prostate Cancer / R. C. Coombes, S. Marsh, J. Gomm, C. Johnston 237

13 Steroid Receptors in Prostate Cancer Development and Progression / Marco Marcelli, Nancy L. Weigel, Dolores J. Lamb 255

14 Type I Family Growth Factor Receptors and Their Ligands in Prostate Cancer / K. E. Leverton, W. J. Gullick 277

15 Hormonal Manipulation of Prostate Cancer / Jeffrey M. Kamradt, Kenneth J. Pienta 293

16 Endocrinology of Epithelial Ovarian Cancer / Vicki V. Baker 313

17 Molecular Pathogenesis of Endometrial Cancer: The Role of Tamoxifen / Yukio Sonoda, Richard R. Barakat 325

18 Structure and Function of BRCA Genes / Kenneth L. van Golen, Sofia D. Merajver 337

19 Role of Apoptosis and its Modulation by Bcl-2 Family Members in Breast and Prostate Cancer / Venil N. Sumantran, David R. Beidler, Max S. Wicha 353

20 Transcriptional Coactivators in Cancer / Paul S. Meltzer 373.

Notes:

Includes bibliographical references and index.

ISBN:

0896036219

OCLC:

43673172